Navigation Links
Cell growth technology promises more successful drug development
Date:9/18/2007

Scientists have developed unique technology to grow stem cells and other tissue in the laboratory in conditions similar to the way they grow in the human body.

The technology, developed and patented by scientists at Durham University and its spin-out company ReInnervate Limited, is a plastic scaffold which allows cells to be grown in a more realistic three-dimensional (3D) form compared to the traditional flat surface of a Petri dish.

Evidence gathered by the research team shows that the technology is a cheap and straightforward way of cultivating cells in 3D. Using it could lead to more successful drug development programmes and a reduction in unnecessary tests on animals.

A study proving the effectiveness of the scaffold, funded by ReInnervate and the Engineering and Physical Sciences Research Council (EPSRC), is published today in the Journal of Anatomy.

A large proportion of drugs fail at the testing stage, costing industry millions of pounds in research and development costs and failed drugs trials every year. At the moment, most drugs in development are first tested on cells grown in two-dimensions (2D) in standard laboratory equipment such as Petri dishes or flasks but cells in the human body form tissues and grow in more complex, three-dimensional ways.

The new study tested the toxic effect of a cancer drug called Methotrexate (MTX) on liver cells grown in three and two dimensions. Liver cells are frequently used in the drug development industry to test the toxicity of drugs and MTX is known to cause liver damage at high doses.

Tests showed that the structure and properties of the cells grown using the 3D scaffold were most similar to liver cells found in the human body, compared with the 2D cells which appeared disorganised when viewed under the microscope.

When subject to doses of MTX, cells grown in 2D died at very low concentrations, whereas 3D cells grown using the scaffold were
'/>"/>

Contact: Dr. Stefan Przyborski
stefan.przyborski@durham.ac.uk
44-191-334-1341
Durham University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. More The Usage More The Growth In The Adult Brain.
2. A new growth factor identified
3. Anthrax drug doxycycline could stunt fetal growth
4. Anti-Cancer Drug Restores Normal Cell Growth
5. Zinc may enhance growth in Young sickle cell patients
6. Drug stabilizes cancer growth
7. Enzyme stimulates growth of adult stem cells
8. Mental growth in babies at risk
9. Low-dose Growth Hormone (GH) with diet and exercise may help weight loss
10. New Molecule that can stop the growth of Viruses
11. Human Growth Hormone Found To be Dangerous For Human Use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post ... insurance policy . , Auto insurance quotes help many ... no longer necessary to call an agent or visit an ... on a single website: http://autocarinsurancebest.com/ . , Every business ...
(Date:1/22/2015)... 2015 A study recently published ... journal Medicine & Science in Sports & Exercise ... help reduce gastrointestinal (GI) problems associated with physical ... in the double-blind, placebo-controlled study took 10 grams ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Four years since the ... – which coincided with the marriage of Avasa & Matthew Love ... ROAD, which is scheduled for release through White Swan Records on ... that there is a sacred path available to all of us ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store for wedding ... its latest collection of wedding dresses , and launches a ... the wedding dress on your big day; the wedding gown ... bride wants to find the most suitable wedding dress. Now, ...
(Date:1/22/2015)... NORCROSS, Ga., USA (PRWEB) January 22, 2015 ... implementing a statewide data management system with support from ... Germany. , The new solution will leverage Hexagon Geospatial’s ... raster and vector data as well as point clouds ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... Rock and Roll Hall of Famer, Marky Ramone of the world-famous ... ... NEW YORK, Feb. 7 The American Social Health Association,(ASHA) recognizes ... sex practices have never been more critical. Despite,hundreds of millions of ...
... 19, 9 a.m. - 5 p.m.), SCOTTSDALE, Ariz., ... Dental Health Month. Dr. Lee Weinstein, a leading ... Associates for Kids Only, will be offering a Free Children,s ... until 5 p.m., The first 30 patients that call ...
... zebrafish in a bid to understand the causes of an ... team will use the model organism to investigate Lowe syndrome, ... a rare disorder that produces cataracts of the eyes, defects ... said Dr Martin Lowe, who will head the research. , ...
... react to stress may provide an important clue to ... reduce their painful effects, says Queens University Biology professor ... Robertson is using insect models to examine how the ... high temperatures and oxygen deprivation. They have discovered that ...
... Operations Research and the Management Sciences (INFORMS) today announced ... Edelman Award for Achievement in Operations Research and the ... , Reflecting the wide-ranging use of operations ... teams from Western Europe, and two federal agencies. , ...
... for Military Biomaterials Research (CeMBR), part of the New ... the development of a breakthrough spray-on dressing for injuries. ... medical device company in Norcross, Ga., received clearance for ... Feb. 1. , The GelSpray Liquid Bandage is a ...
Cached Medicine News:Health News:Beating to the Drum of Safe Sex 2Health News:Beating to the Drum of Safe Sex 3Health News:Free Children's Dental Day; Expert Source on Children's Dental Health Available 2Health News:Might fish provide Lowe-down on boyhood disease? 2Health News:Comatose locusts may help relieve migraines 2Health News:World's best analysts compete to win Edelman Prize in operations research and analytics 2Health News:Rutgers center sparks 'liquid bandage,' a new frontline wound treatment 2
(Date:1/23/2015)... 2015  HyGreen, Inc., a leader in hand hygiene monitoring, ... Medical, a subsidiary of Ascendis Health Limited, in ... year, hundreds of millions of patients around the world ... transmitted from patient to patient via the unwashed hands ...
(Date:1/23/2015)... 2015 Cord Blood America, Inc. ( www.cordblood-america.com ) (OTC ...  filed a Preliminary Proxy Statement, Schedule 14A, with the U.S. ... an update for shareholders detailing why a "YES" vote to ... Dear Shareholders, As we reflect upon the 2014 ...
(Date:1/23/2015)... 23, 2015 Gem Pharmaceuticals announced today that the ... into the Company,s Phase 2 clinical trial.  This open-label ... lead compound, GPX-150 (an investigational medication), in approximately 30 ... Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
Breaking Medicine Technology:HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2
... Model 6495 Bipolar Coaxial Temporary Pacing Lead ... bipolar technology based on the sensing and ... Unipolar Temporary Pacing Lead., ,The Streamline Temporary ... temporary sensing and pacing during and after ...
... of temporary sensing and pacing leads. Our ... temporary pacing leads and improved upon the ... and less traumatic to heart tissue. , ... to provide consistent temporary sensing and pacing ...
... device was designed specifically to obviate the ... The eNcloseII device can provide the surgeon ... better hemodynamics as compared to partial occlusion ... suggested that complete or partial clamping of ...
... Carpentier-Edwards Classic annuloplasty rings have ... choice for more than 30 ... restore the anatomical size and ... to help prevent recurrent dilatation. ...
Medicine Products: