Navigation Links
Cell energy sensor mechanism discovered
Date:2/21/2012

esearchers concluded. AMPK acts like an energy thermostat because when energy levels are low in the cell, AMPK kick-starts processes that use the cell's energy reserves and cuts off reactions that store energy. On the other hand, when the cell has plenty of energy, AMPK turns off, causing energy in the form of sugar and fats being stored for later use.

Because the HDAC1 protein turned on AMPK, the researchers presumed there would be a corresponding acetyl-adding enzyme to specifically turn off AMPK. To find this enzyme, they extracted AMPK protein from eight different cell lines, each with reduced levels of a type of acetyl-adding enzyme. They found that AMPK in cells with reduced levels of this acetyl-adding enzyme, called p300, was less acetylated than in cells containing normal amounts of p300.

To confirm the idea that adding or removing acetyl groups directly affects how AMPK controls the way the cell uses energy, they measured the cell's energy stores with the help of a dye that accumulates in the fat globules of a cell. The dye let them estimate the size of fat globules that store energy. The cells unable to add acetyl to AMPK contained less of the dye and therefore smaller fat globules compared to normal human cells. Conversely, the cells unable to remove acetyl groups from AMPK contained more of the dye, indicating bigger fat globules. The research team concluded that when AMPK contains acetyl groups the cell uses less of its energy reserves than when AMPK does not contain acetyl groups.

Boeke says the work on human cells followed similar studies on yeast energy proteins done earlier in his laboratory.


'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Energy Drinks, Alcohol a Dangerous Mix
2. Heel-First Walking Conserves Energy
3. Drugs That Shift Cells Energy Find New Purpose
4. Scientists find donut-shaped structure of enzyme involved in energy metabolism
5. Artificial foot recycles energy for easier walking
6. Federal Recovery Funds Allow Eries Shriners Hospital to Reduce Energy Costs, Invest Savings in Patient Care
7. It's Snow Joke as UK Gas and Electricity Bills Hit Record Highs -- Energyhelpline Calls for “Significant” Price Cuts
8. Dr. Catherine Ross to Participate Today in White House Clean Energy Economy Forum
9. National Climate Organizations Join Forces In Historic Push For Climate and Clean Energy Solutions
10. Johns Hopkins Launches “Energy Policy and Climate” Master's Degree
11. American DG Energy Generates Clean Energy at Continuing Care Facility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2012)... Ind. -- Two popular MTV programs about teenage pregnancy ... met with national debate. Critics said the shows glamorized ... A new study by an Indiana University professor suggests ... in the journal Sexuality & Culture, focused ... associated with pregnancy among this demographic. , When the ...
(Date:5/22/2012)... Colonoscopies helped doctors detect a high rate of ... screening for the first time, a new study ... be made available to otherwise healthy elderly people ... research fellow at Grand Rapids Medical Education Partners, ... Grand Rapids, Mich., concluded. For the study, ...
(Date:5/22/2012)... 42/2010, which extends the smoking ban to public places, ... smokers (from 40.3% to 35.3%) and in consumption amongst ... women of all ages and occupations. , ... by the Society of Prevention of Ibermutuamur (accidents and ... consumption of tobacco in the working populating during the ...
(Date:5/22/2012)... May 22 (HealthDay News) -- Body-building and weight-loss products ... cause liver injury, according to a small new study. ... drugs are taken off the market. Dietary and herbal ... can be bought over the counter or online -- ... in the United States, but their potential side effects ...
(Date:5/22/2012)... A novel pancreatic cancer vaccine shows promise in ... new research out of University Hospitals Case Medical Center,s ... of Medicine. The Phase 2 data was presented today ... the Society for Surgery of the Alimentary Tract, part ... In the plenary session titled "Addition of Algenpantucel-L Immunotherapy ...
Breaking Medicine News(10 mins):Health News:Viewers' family background affects how they react to MTV shows 16 and Pregnant, Teen Mom 2Health News:Viewers' family background affects how they react to MTV shows 16 and Pregnant, Teen Mom 3Health News:Colonoscopy May Detect Curable Cancer in Elderly: Study 2Health News:5 percent of workers gave up smoking when the anti-tobacco law took effect 2Health News:Body Building, Diet Supplements Linked to Liver Damage: Study 2Health News:Researchers present new findings for novel pancreatic cancer vaccine 2
... patient and staff safety and minimizing waste ... ... The convergence of a world-class,sales and service organization and a ... and ultimately transform,the way cancer fighting drugs are prepared and ...
... (Nasdaq: HALO ), a biopharmaceutical company developing and,commercializing ... has been selected for addition to the NASDAQ Biotechnology ... Launched in 1993, the NASDAQ Biotechnology Index is ranked ... as the basis for the,iShares NASDAQ Biotechnology Fund (Amex: ...
... Northwestern University,announced today that it has ... for women with locally recurrent or metastatic ... efficacy of Nexavar(R),(sorafenib) tablets in combination with ... Nexavar, an oral multi kinase inhibitor being,co-developed ...
... YORK, Nov. 12 Country music superstar,Sara Evans is ... by serving as chair of the 3rd Annual Every ... underway by the National,Eating Disorders Association (NEDA)., Open ... by going to, http://www.nationaleatingdisorders.cmarket.com . There are more than ...
... clinical psychologists has found that teens who have sex at ... behavior in early adulthood than their peers who waited until ... that early sex may play a role in helping these ... is published in the current online edition of the Journal ...
... by Glenn Close Premieres November 18 at 9 ... AM ET/PT on Discovery Health ... earth is,affected by diabetes -- one of the most pressing health ... with the disease, a number that is expected to explode to ...
Other Medicine News:Health News:Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding 2Health News:Halozyme Therapeutics Added to Nasdaq Biotech Index 2Health News:Northwestern University and ACORN Commence National Enrollment for Metastatic Breast Cancer Study 2Health News:Northwestern University and ACORN Commence National Enrollment for Metastatic Breast Cancer Study 3Health News:Country Music Star Sara Evans Hosts Online Auction for National Eating Disorders Association 2Health News:Early teen sex may not be a path to delinquency, study shows 2Health News:Discovery Health Travels the World to Present the Groundbreaking Documentary - Diabetes: A Global Epidemic 2Health News:Discovery Health Travels the World to Present the Groundbreaking Documentary - Diabetes: A Global Epidemic 3Health News:Discovery Health Travels the World to Present the Groundbreaking Documentary - Diabetes: A Global Epidemic 4
(Date:5/22/2012)... Generics, a division of Prodigy Health Supplier Corporation ... generic equivalent of the branded drug Camptosar by ... Laboratories to develop a portfolio of oncology products. ... developed through the partnership that will add consistent ... market, which has experienced record levels of shortages ...
(Date:5/22/2012)... May 22, 2012  MusclePharm Corporation (OTCBB: MSLP.OB), ... today announced that it has signed Major League ... of the agreement were not disclosed. ... Nationals, made his professional baseball debut on April ... pick in the 2010 baseball draft, after earning ...
(Date:5/22/2012)...  Boehringer Ingelheim announced today results from ... compound tiotropium delivered once-daily via the Respimat ... moderate persistent asthma. The data were presented ... American Thoracic Society (ATS 2012). Boehringer Ingelheim ... trial program named UniTinA-asthma™ is ongoing to ...
Breaking Medicine Technology:MusclePharm Signs Pro Baseball Rookie Phenom Bryce Harper As Sponsored Athlete 2Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma 2Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma 3Boehringer Ingelheim Presents First Data for Tiotropium in Adolescents with Moderate Persistent Asthma 4Long Beach Fit Body Boot Camp Commits 100 25 to Help the 26amp 3B 238216 3BBoys and Girls Club of Long Beach 26apos 3B 72033 1Long Beach Fit Body Boot Camp Commits 100 25 to Help the 26amp 3B 238216 3BBoys and Girls Club of Long Beach 26apos 3B 72033 2New Electronic Medical Record 28EMR 29 Software MxChart 26amp 3B 238482 3B Launched by Medical Transcription Service Provider MxSecure 72031 1New Electronic Medical Record 28EMR 29 Software MxChart 26amp 3B 238482 3B Launched by Medical Transcription Service Provider MxSecure 72031 2New Electronic Medical Record 28EMR 29 Software MxChart 26amp 3B 238482 3B Launched by Medical Transcription Service Provider MxSecure 72031 3Biosense Webster Reinforces its Leadership Position in the Electrophysiology Market at Heart Rhythm 2010 16306 1Biosense Webster Reinforces its Leadership Position in the Electrophysiology Market at Heart Rhythm 2010 16306 2Biosense Webster Reinforces its Leadership Position in the Electrophysiology Market at Heart Rhythm 2010 16306 3Biosense Webster Reinforces its Leadership Position in the Electrophysiology Market at Heart Rhythm 2010 16306 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: