Navigation Links
Cell division find prompts overhaul of immune response modeling
Date:7/21/2009

Research at the Walter and Eliza Hall Institute into the mechanics of how two types of white blood cells grow and die is fundamentally changing the development of computer models that are used to predict how immune system cells respond to a pathogenic threat.

A team led by Professor Phil Hodgkin, head of the institute's Immunology Division, is investigating the proliferation and survival of T and B lymphocytes white blood cells that are crucial to the body's ability to generate immunity.

When lymphocytes are exposed to pathogens they are stimulated to undergo a series of cell divisions, which increases the number of lymphocytes many hundredfold. After a period the cells stop dividing and 95 per cent of the newly-generated cells die.

Professor Hodgkin said although there was considerable variation in the number of divisions cells went through before they died, existing computer models had been developed assuming all cells were mechanically identical. However, biologists have long been aware that cells never behave identically. This variation is usually dismissed as 'noise' or irrelevant biological variation.

"About 10 years ago I was struck by the thought that by ignoring the immense amount of variation in cells we might be missing something important," Professor Hodgkin said. "What if the variation is a design feature of the cells? What if they're doing it deliberately? My lab has been pursuing the implications of this idea ever since."

In an attempt to revamp computer models of the immune response to accommodate individual cells, Dr Edwin Hawkins, Dr John Markham and Mr Liam McGuinness at the Walter and Eliza Hall Institute, for the first time in science, followed hundreds of lymphocytes and their offspring through all their cell divisions until their deaths. They also recorded how this variation in lymphocyte behaviour was transmitted through cell generations.

The research has been published today in the Proceedings of the National Academy of Sciences USA.

"We found that all the offspring of a single cell died at the same cell division; their lifespan is programmed from that very first cell," Professor Hodgkin said. "We also observed that cell 'siblings' took a similar amount of time to die. This tells us that a very large part of the fate of individual cells is locked in and programmed early."

Professor Hodgkin said it appeared that when a lymphocyte first divided chemicals were produced that were progressively diluted as the cell went through its divisions. When levels of these chemicals fell below a certain threshold the cells stopped dividing and died, he said.

"With accurate information on the time it takes for a lymphocyte to divide, the time taken to die and the number of cell divisions an individual cell goes through, we can develop new mathematical models that are correct not only at a single-cell level but that also hold true for a whole population of cells."

Accurate computer-based models of the immune response are a holy grail for scientists as they promise to unlock new therapies for infectious diseases, and allow careful investigation of autoimmune conditions.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related medicine news :

1. Air Ambulance and Life Flight Service Angel Medflight Adds Two to Client Advocates Division
2. Air Ambulance and Life Flight Service Angel Medflight Adds Two to Client Advocates Division
3. Online Voting Begins for Ford Customer Service Divisions Second Annual Funny Car Design Contest to Support Juvenile Diabetes Research Foundation
4. Team Full Throttle Twinlab(R) Racing Nabs Podiums in Several Divisions at the 2009 Robert J. Aaron Memorial Mighty Montauk Triathlon
5. Anglo Americans Coal Division in South Africa Wins Global Business Coalition Award for top International Workplace HIV and AIDS Programme
6. American Dental Hygienists Association and Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc. Announce Honorees of HYGIENIST HERO(R) Recognition Program
7. Nottingham Primary Care Division a UK leading center
8. Thomas McKeever to Spearhead Jackson & Coker's National Accounts Division
9. Senior Citizens Bureau Creates New Resourceful Divisions
10. New Poll on Obama, Catholics and the Notre Dame Commencement Finds Deep Divisions Among Catholics
11. BioMedical Technology Solutions, Inc. a Division of BioMedical Technology Solutions Holdings, Inc. Symbol (BMTL) OTCBB Receives Frost & Sullivans Product Innovation of the Year Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell division find prompts overhaul of immune response modeling
(Date:12/7/2016)... Norwalk, CT (PRWEB) , ... December 07, 2016 ... ... the Integrated Infertility and Wellness (IFW) Program at Reproductive Medicine Associates of Connecticut ... which now has a team of three acupuncturists to help patients realize their ...
(Date:12/7/2016)... ... ... With God: Inspirational Lessons from My Life's Journey”: a sometimes serious, sometimes humorous ... in their lives. “Walking With God: Inspirational Lessons from My Life's Journey” is the ... , Sanford says, “I enjoy sharing the true stories in my book as examples ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... annual Business Architecture Innovation Summit in Reston, VA on March 21-22, 2017. This ... share a range of experiences from a cross-section of industries such as financial ...
(Date:12/7/2016)... ... December 07, 2016 , ... "Hacking into my medical ... described him as 'a genius.'" Thus begins "Margaret in Berlin," Book Twelve in the ... by Wyston Books, Inc. These novels narrate the lives of a poor ...
(Date:12/6/2016)... ... December 06, 2016 , ... Men with gum disease ... of serious health problems, such as cardiovascular illness, according to research cited in ... Hills Periodontics & Dental Implant Center notes that the correlation between periodontal disease ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016   Arena Pharmaceuticals, Inc. ... it has completed enrollment in the ralinepag phase 2 ... targeting the prostacyclin pathway for the treatment of pulmonary ... at sites globally. "This marks an important ... of our strategic focus on our pipeline," said ...
(Date:12/7/2016)... Diplomat Pharmacy, Inc. (NYSE: DPLO) has launched Diplomat Specialty Infusion Group, ... Professional, BioRx, MedPro Rx, and XAS Infusion Suites. To ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ... we continue to build on the work we have done, we ...
(Date:12/7/2016)... 2016   Rx Savings Solutions has partnered with ... its Public Employees Insurance Agency (PEIA) to offer more than ... healthcare software, ultimately saving money on their prescriptions. ... members with access to our software that will alert them ... therapy can be found," says Michael Rea , founder ...
Breaking Medicine Technology: