Navigation Links
Cell division discovery could offer fresh insight into cancer
Date:1/14/2014

New findings on how the cells in our bodies are able to renew themselves could aid our understanding of health disorders, including cancer.

Scientists have explained a key part of the process of cell division, by which cells are able to keep our organs functioning properly.

They discovered a set of proteins that stabilise the sequence of events in which cells duplicate their DNA and then separate into two new cells, each identical to the original. Flaws in this delicate, complex operation can lead to cancer.

The findings help explain a fundamental process in all living things, in which cells must continually divide to keep the organism alive and well.

Researchers at the University of Edinburgh found that a set of proteins, known as the Ska complex, help anchor DNA, the form of chromosomes, by interacting with strands of cell material. Chromosomes remain attached to these strands as they are separated, in a process that helps distribute DNA correctly to the newly formed cells.

Scientists determined the structure of the relevant part of the protein complex by analysing crystals of it with lab tools and cell-based experiments. This showed how the Ska complex attaches to the strands, helping to bind the DNA material.

The study, published in Nature Communications, was carried out in collaboration with the University of Basel, Technische Universitt Berlin, and the National Institute of Immunology in New Delhi and funded by the Wellcome Trust.

Dr JP Arulanandam, of the University of Edinburgh's School of Biological Sciences, who led the work, said: "Our findings represent a milestone in resolving the mystery of how these key proteins enable new cells to separate properly and equally, in this essential process for life. The findings of our work have the potential to create new avenues in drug discovery towards fighting cancer."


'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Page: 1

Related medicine news :

1. Oakworks Medical, a Division of Oakworks Inc., Oakworks.com, Manufacturer of Medical Tables and Positioning Devices Announces ISO 13485 Certification
2. Catalan researchers identify a key component of cell division
3. UMass Amherst cell biologists identify new protein key to asymmetric cell division
4. New form of cell division found
5. More sex for married couples with traditional divisions of housework
6. Stemedica Forms Cardiology Division. Sergey Sikora, PhD Appointed As Division President
7. Dr. Steve Carstensen Presents First Webinar for Dental Division of American Sleep and Breathing Academy
8. MDWebPro, a division of Digital Solutions, Inc. Releases "Healthcare Social Media Week in Review #HSCM: February 11, 2013
9. Rapid Insight New Hire Launches Healthcare Predictive Analytics Division
10. MDWebPro, a division of Digital Solutions, Inc. Releases Information About a New Addition to the MDWebPro Team, Tyler Weber, Public Relations Director
11. Balboa Capital Expands Franchise Financing Division
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Bcl-2-like protein 11 (BIM) deletion in advanced ... shorter progression free survival (PFS) in epidermal growth ... chemotherapy treated Asian patients. Also, BIM deletion independently ... , The BIM protein can activate the programmed ... in cells. BIM deletion has been detected in ...
(Date:8/22/2014)... Rheumatoid arthritis (RA), a complex autoimmune disease that ... patients to not only cope with pain, disability ... as disrupted work, family life and marital functioning. ... residual pain and disability is common. In addition, ... high cost or side effects. Because of this, ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Advancements ... for some clinical applications due to their cost-effectiveness, ... emerging innovations in ultrasound, such as the evolution ... expected to keep the market moving throughout 2014 ... mobility can enhance not only the point-of-care (POC) ...
(Date:8/22/2014)... Sac, Wisconsin (PRWEB) August 22, 2014 ... System for Plantar Fasciitis, an exciting new product that ... allows you to stay active while you heal. The ... This is truly a new technology – it is ... affordable. , FasciaDerm® PFTape™ System for Plantar Fasciitis ...
(Date:8/22/2014)... intensive effort to sterilize feral cats reduced the number of ... a new study reveals. "We investigated whether we ever ... control," Dr. Julie Levy, a professor of shelter medicine at ... a university news release. "Neutering a few cats ... "so we wanted to pick a focused area and throw ...
Breaking Medicine News(10 mins):Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:Study shows cognitive-behavioral coping skills training has positive effects on rheumatoid arthritis 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 3Health News:Mueller Introduces FasciaDerm® PFTape™ System for Plantar Fasciitis 2Health News:Neutering Project Curbed Feral Cat Population 2
... a potential heart attack risk? According to a recent study, ... with the strengthening of the US economy., ,Christopher Ruhm, ... Greensboro wrote in his study that there is a pronounced ... economy grows further with no improvement in the rate of ...
... to a study conducted by the University of Erfurt ... willing to inflict financial pain to achieve// collective gain. ... ,Researchers have found that groups in ... were more popular than groups without this option. Though ...
... According to experts approximately 6,000 plus trampolining fractures were ... for new safety guidelines// are needed to stem the ... in a study has found a "worrying trend" in ... in the home. ,The Royal Berkshire in ...
... doesn’t seem to have learnt its lessons yet, because there ... of AIDS/HIV//. Next only to South Africa with the highest ... million mark as per statistics in 2003, very little has ... AIDS/HIV cases, according to Prof Suzanne Crowe, Deputy Chairperson of ...
... Pharma has come up with a new neupro skin patch ... It is said to offer relief to patients// in the ... mimics the effects of a naturally occurring brain chemical, which ... ,The Parkinson's Disease Society said that the patch would aid ...
... It’s learning time for countries, and Vietnam’s tryst with ... management//. Vietnamese Farmers appear to know much more about ... their counterparts in Europe and Africa. Not surprising, since ... the onslaught of bird-flu, which in 2003 had claimed ...
Cached Medicine News:Health News:Competitive Advantage Are Attained In Which Freeloaders Are Punished 2Health News:Competitive Advantage Are Attained In Which Freeloaders Are Punished 3Health News:Competitive Advantage Are Attained In Which Freeloaders Are Punished 4Health News:Be cautious while on the Trampoline 2
(Date:8/21/2014)... 2014  Publicis Groupe customer engagement agency ... and Healthcare Industry Group Leader, has been featured in ... most inspiring people in the life-sciences industry. Those chosen ... development, marketing, technology, creativity, strategy and medicine. ... partner in its leading Rosetta Consulting practice. In 2012, ...
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... Brazil and ... and commonly prescribe long-acting beta-agonist (LABA)- and long-acting ... so within current severe cost/coverage constraints. Therefore, new ... expected to launch in these countries—which will considerably ...
(Date:8/21/2014)... 21, 2014 /PRNewswire-iReach/ -- ScriptPro has been certified ... its Common Security Framework (CSF). According to ... Manager, "We appreciate this rigorous, top-to-bottom audit. Security-minded ... this certification signifies. Our business partners need to ... CSF CERTIFICATION PROCESS: ScriptPro,s internal security processes and ...
Breaking Medicine Technology:Shannon Hartley Shines in PharmaVOICE 100 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3ScriptPro Achieves HITRUST Certification 2
... Johnson & Johnson (NYSE: JNJ ) today ... & Diagnostics (MD&D) and Sheri McCoy, currently Worldwide Chairman, ... Committee and join William C. Weldon, Chairman of the ... of the Chairman.  Both appointments are effective January 3, ...
... LAKE FOREST, Ill., Dec. 15, 2010 RoundTable ... focused exclusively on the healthcare industry, announced today ... to sell one of its portfolio companies, Clinical ... private investment firm representing Pritzker family interests.  Terms ...
Cached Medicine Technology:Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 3RoundTable Healthcare Partners Announces Sale of Clinical Innovations, LLC to The Pritzker Group 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: