Navigation Links
Cell differentiation as a novel strategy for the treatment of an aggressive type of skin cancer
Date:7/9/2012

Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, little is known about the biology of these cells, which consequently makes difficult the generation of new specific therapies; actually, the standard treatments are based on surgery and subsequent radiotherapy.

Researchers at the Spanish National Cancer Research Centre (CNIO) led by Erwin Wagner, vice-director of Basic Research and director of BBVA Foundation-CNIO Cancer Cell Biology Programme, have discovered a molecular mechanism that favours the disappearance and inhibition of SCC development. The authors propose that these mechanisms could be crucial for the development of targeted therapies that could potentially overcome drug resistance.

The study, which also involves the participation of medical researchers at the Medical University of Vienna, Austria, is published today on the online edition of The Journal of Clinical Investigation.

"The guardian of the genome" p53, decreases cell division in favour of cell differentiation

Using in vitro models, mouse genetic models and human tumors, researchers have uncovered the molecular signals by which the p53 protein, also called "the guardian of the genome", prevents the formation of skin SCC tumors.

"We demonstrate for the first time that p53 promotes differentiation [cell functional specialization] of keratinocytes [the most predominant cell type in the epidermis], thus avoiding their division and providing a protective effect against tumors", states Juan Guinea Viniegra, "Ramn y Cajal" investigator at the CNIO and first author of the work.

The alteration of these pathways decreases cell differentiation and hence produces an increase in cell division. "We found that samples from patients with skin SCC show reduced activity of proteins that promote cell differentiation and an overactivation of inhibitory signals," says Guinea.

An additional contribution of this work is the use of compounds that induce cell differentiation at the expense of cancer cell division. "The next step is to test these molecules in mouse models of skin cancer and assess whether they impair cell division and tumor development", reveals the author.

Treatment of tumors based on differentiation therapies is a new avenue in the development of innovative cancer treatments. These therapies, unlike conventional ones, seek to transform cancer cells into differentiated cells, which remain in the body with few possibilities to divide and likely avoiding the appearance of drug resistance.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Novel radiation therapy safely treats prostate cancer and lowers the risk of recurrence
2. LA BioMed investigators, Drs. Kevin Bruhn and Noah Craft, develop novel treatment for melanoma
3. Novel Anti-Inflammatories May Offer a New Approach for the Treatment of Stroke
4. Novel Natural Sciences Repository Opens Web Portal
5. Study supports urate protection against Parkinsons disease, hints at novel mechanism
6. VCU Massey Cancer Center sees potential in novel leukemia treatment
7. Novel biomarkers reveal evidence of radiation exposure
8. Researchers present new findings for novel pancreatic cancer vaccine
9. Novel drug candidates offer new route to controlling inflammation
10. Rutgers team discovers novel approach to stimulate immune cells
11. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2016)... (PRWEB) , ... May 01, 2016 , ... Outdoor Growing ... medical marijuana industry, has put the law in the hands of the local ... January 1, 2016, California voted to allow counties to vote on growing regulations by ...
(Date:4/30/2016)... Marne, Michigan (PRWEB) , ... May 01, 2016 , ... ... holistic approach to rehabilitation, has produced a new video that focuses on one of ... of their recent sessions and clips from interviews with a participating patients and the ...
(Date:4/30/2016)... ... April 30, 2016 , ... Powerful tools of ... Mary O'Maley. What is hypnosis and hypnotherapy and why after centuries, it ... pain relief (chronic and acute), birthing processes and medical procedures, depression, anxiety, fear ...
(Date:4/30/2016)... Austin, Texas (PRWEB) , ... April 30, 2016 ... ... time to celebrate the profession and recognize veterinarians’ global impact on public health. ... choose a theme each year, and this year have selected continuing education with ...
(Date:4/30/2016)... ... April 30, 2016 , ... ... 4th, 2016 questioned the use of the HyProCure sinus tarsi implant. ( ... procedure.” EOTTS-HyProCure is a minimally invasive procedure performed, when indicated, to correct ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 2016 Automation is one of ... to the growing demands for productivity in speed, accuracy, ... systems are already adept of a wide range of ... manual labor. Instrumentation continues to evolve, and is poised ... a few years ago. Originally used mostly by the ...
(Date:4/28/2016)... April 28, 2016  While Abbott,s announced purchase ... company,s valve repair and stent business, healthcare research ... Abbott more firmly into patient monitoring.  Kalorama said ... growing device areas, with double-digit growth expected the ... Advanced Remote Patient Monitoring . Abbott ...
(Date:4/28/2016)... April 28, 2016  Marking its one year ... and ovarian cancer risk test, Color Genomics ... genes that highly impact the most common hereditary ... the Color Test analyzes hereditary cancer risks for ... uterine cancers. The Color Test is physician ordered ...
Breaking Medicine Technology: