Navigation Links
Cell-death receptor links cancer susceptibility and inflammation
Date:12/27/2007

mice without the TRAIL receptor that were irradiated developed chronic pneumonia, an inflammatory response, as well tumors, evidence pointing to the connection between cancer and inflammation via TRAIL. One benefit of this work is that it provides a new and unanticipated model implicating a TRAIL pathway deficiency in the chronic toxicity of radiation therapy, he notes. Inflammation is a common late and serious side-effect of radiation treatment in people.

El-Deiry and his team are now looking within tumor tissue for inflammatory molecules as clues to how cancer and inflammation are coupled. Our work with TRAIL and its receptor in mouse models represents a new way to look at cancer susceptibility and its potential therapy in humans as well as new ways to decrease debilitating radiation side-effects experienced by cancer patients, says El-Deiry.

Co-authors in addition to El-Deiry are Niklas Finnberg from Penn and Andres J.P. Klein-Szanto from Fox Chase Cancer Center, Philadelphia. This research was funded in part by the National Cancer Institute.

This release can be found at www.pennhealth.com/news.


'/>"/>
Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
2. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
3. Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay
4. Pharmacopeia Acquires Selective Androgen Receptor Modulator (SARM) Program from Bristol-Myers Squibb
5. Food restriction increases dopamine receptor levels in obese rats
6. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
7. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
8. Exelixis to Receive Milestone Payment From Bristol-Myers Squibb for Achievement of Liver X Receptor Agonist Development Milestone
9. Receptor protein appears to be key in breakdown of kidney filtration
10. Pathway links inflammation, angiogenesis and breast cancer
11. Research Links TV/Video Game Playing With Child Obesity; Health Experts Back a New Approach
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Comparative trials and observational studies previously conducted in ... These studies were performed before intracoronary stents and ... ,Therefore, Dr. Hanoch Hod, of Chaim Sheba ... followed 130 consecutive patients aged 70 or older ...
... vasectomy, contraception is typically left up to the woman. ... in a woman's contraceptive repertoire. Until now, men have ... searching for new options. Now, they may have one.// ... 12 percent. Vasectomies are considered permanent. Dr. Wang, of ...
... of choice for some doctors who think it's time to ... French physician invented it in the early 1800s. "The stethoscope ... allow you to distinguish between a heart that is beating ... ,"Sometimes the heart muscle is very weakened, but unless that ...
... spreads fast, and when it does, it can kill within months. ... tracks. ,Faith was more than a mere crutch for Rev. Jerry ... afraid of dying. My faith sustained me in that, but I ... highly curable if it's caught early, but it does not respond ...
... be found in water which has flowed through arsenic-rich ... drinking arsenic-rich water over long periods in countries world-wide. ... the earth's crust. ,Arsenic is introduced into water through ... groundwater //in some areas are elevated as a result ...
... affects women of child-bearing age, occurs when the the ... rendering them unable to produce eggs. PCOS symptoms include ... have said women// without these symptoms still can have ... though women's health experts caution that not every woman ...
Cached Medicine News:Health News:Angioplasty plus stenting better than thrombolysis for elderly patients with AMI, 2Health News:Arsenic in drinking water 2Health News:Arsenic in drinking water 3Health News:Arsenic in drinking water 4Health News:Arsenic in drinking water 5Health News:Arsenic in drinking water 6Health News:Arsenic in drinking water 7Health News:Arsenic in drinking water 8Health News:Polycystic Ovarian Syndrome(PCOS) linked to Diabetes 2
(Date:12/17/2014)... 2014 PCCA received the Autism Hope ... ) program seal for best practices in meeting ... medical practices, materials and goods that meet strict ... Children affected by autism often have unique physical ... ingredients found in food and medicine – for ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/ms3j8c/cardiac ) has announced the addition of ... Forecasts, 2012-2018"  report to their offering. Global Guidewires ... The North America accounts for ... Europe claims approximately 25% (2018). ...
(Date:12/15/2014)... Dec. 15, 2014  Colorado and Washington State ... adult use of cannabis. Oregon , ... ended prohibition during the November 2014 elections. ... http://photos.prnewswire.com/prnh/20141212/164153LOGO The benefits of legalizing ... obvious benefits like the increased tax revenue for state and ...
Breaking Medicine Technology:Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 2Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 3Cardiac Guidewires - Global Trends, Estimates and Forecasts, 2012-2018 4CannaInsider.com Estimates 200,000 New Jobs in the Cannabis Industry by 2015 2
... BETHLEHEM, Pa., Nov. 14, 2011 MedClean Technologies, Inc. (OTC ... for the 2011 third quarter for the period ended September ... : The company has dramatically improved its ... the following key metrics, representing tangible progress: ...
... /PRNewswire-Asia-First Call/ -- American Oriental Bioengineering, Inc. (NYSE: ... company dedicated to improving health through the development, manufacture ... over the counter ("OTC") products, today announced that it ... call at 8:00 am EST on Tuesday, November 15, ...
Cached Medicine Technology:MedClean Technologies Announces Third Quarter Results 2MedClean Technologies Announces Third Quarter Results 3MedClean Technologies Announces Third Quarter Results 4MedClean Technologies Announces Third Quarter Results 5MedClean Technologies Announces Third Quarter Results 6MedClean Technologies Announces Third Quarter Results 7American Oriental Bioengineering to Hold Third Quarter 2011 Earnings Conference Call at 8:00 AM on November 15, 2011 2
... thermal LP 2824 bar code label printer is ... LP 2824 redefines the compact printer class. It ... handling and integrating easily into a wide range ... capacity and clear media window optimize productivity, while ...
... wristband printing, the H 2824-Z direct thermal ... improved patient safety and privacy. Generating clear ... variety of wristband types, the H 2824-Z ... Starter Kitprints patient identification wristbands on demand. ...
... the H 2824-Z direct thermal barcode printer ... patient safety and privacy. Generating clear bar ... of wristband types, the H 2824-Z direct ... demand. It can also print bar code ...
... the newest member of the ... also the fastest, combining enhanced ... rugged and reliable all-metal construction. ... the 105SL is the choice ...
Medicine Products: