Navigation Links
Cell biologists identify new tumor suppressor for lung cancer
Date:1/5/2009

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer.

The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biology.

Proto-oncogenes are genes that play a role in normal cell growth (turnover of cells and tissue) but, when genetically modified, can cause the out-of-control cell division that leads to cancer. Previous research had established that Ras, a proto-oncogene, is abnormally expressed in up to 25 percent of human lung cancers; however, researchers did not understand the specific cellular events by which abnormal Ras expression leads to transformation.

UC researchers sought to define the interim steps that occur in Ras-induced tumor development to better understand the underlying biological mechanisms leading to cancer.

"These interim steps are critical because they help us determine how best to intervene and stop cancer growth along the way," explains Moscat, corresponding author of the study and chair of UC's cancer and cell biology department. "Right now, cancer therapy is delivered with a sledgehammer and it needs to be more like a scalpel so we avoid unnecessary harm to the body."

Using a genetically modified mouse model, the UC team found that animals who didn't express a certain gene (protein kinase C (PKC)-zeta) developed more Ras-induced lung cancer, suggesting a new role for the gene as a tumor suppressor.

"PKC-zeta would normally slow down Ras transformation and put the brakes on tumor development, but when PKC-zeta is missing or inactive as a result of genetic alterations, tumor growth actually accelerates," explains Moscat. "Until now, we did not know the specific chain of events that led to Ras-induced lung cancer. Our study fills in important missing information that will enhance our overall under
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Biologists Discover How Dengue Virus Matures
2. Boston College biologists build a better mouse model for cancer research
3. Microbiologists receive top Canadian recognition
4. UCLA researchers identify markers that may predict diabetes in still-healthy people
5. Emory researchers identify signaling protein for multiple myeloma
6. Dermatologists identify North Texas leishmaniasis outbreak
7. Supplier Assessments to Help Buyers Identify Reliable China Exporters
8. Cancer cells in blood can identify risk of recurrence in breast cancer
9. Radiologists identify early brain marker of Alzheimers disease
10. Running shipwreck simulations backwards helps identify dangerous waves
11. Researchers identify genes that increase rheumatoid arthritis risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... June 2011 The Reed Elsevier Environmental Challenge aims ... and sustainable water supply for communities where it is ... $50,000 first prize, announced today, is Tagore-SenGupta Foundation. Their ... in remote villages and schools in Cambodia where arsenic ...
... highlights that while the risk of post-traumatic stress disorder (PTSD) ... migraine irrespective of sex, the risk is greater in male ... Headache: The Journal of Head and Face Pain , ... In this paper, lead author B. Lee Peterlin ...
... range of new "apps" and other technologies harnessing health ... demonstrated at the Health Data Initiative Forum, hosted by ... and Human Services, on Thursday, June 9. IT ... gather at the event hosted by the Institute of ...
... bona fide media presenting official press credentials , Media ... & IT support, English, Swedish, Spanish, German, and French ... is English] News briefings will be held:, ... CEST Monday 4 July (English), 14.00 hrs CEST Monday ...
... to suffer surgical site infections (SSIs) if the operating theatre ... of BJS, the British Journal of Surgery . ... surgery, exploring demographic parameters, the duration of the operation and ... per cent) developed SSIs and the only variable was the ...
... Asian non-small cell lung cancer (NSCLC) patients survive longer than ... first-line setting, and the effect was apparent both before and ... according to research published in the June issue of the ... Asian patients with a common type of lung cancer, the ...
Cached Medicine News:Health News:Reed Elsevier Environmental Challenge winners announced 2Health News:Sex matters -- more men with migraine suffer from PTSD than women 2Health News:Sex matters -- more men with migraine suffer from PTSD than women 3Health News:Health data forum features dynamic apps, experts on June 9 2Health News:European Society of Human Reproduction and Embryology Annual Meeting July 3-6, 2011, Stockholm 2Health News:European Society of Human Reproduction and Embryology Annual Meeting July 3-6, 2011, Stockholm 3Health News:Noisy operations associated with increased infections after surgery 2Health News:Asian lung cancer patient survival exceeds Caucasians' on multiple regimens 2
(Date:12/22/2014)... Tenn. , Dec. 22, 2014   TRU-D ... automated, no-touch UV disinfection robot, announced today that the ... Schedule contract through November 2019.   This ... rapidly engage all levels of government purchasers, including Department ... as well as Homeland Security contacts purchasing solutions for ...
(Date:12/22/2014)... HOUSTON , Dec. 22, 2014 Cyberonics, Inc. ... devices for the treatment and management of epilepsy, today announced ... Morgan Healthcare Conference on Wednesday, January 14, 2015, in ... , Cyberonics, President and Chief Executive Officer, will speak at ... presentation can be accessed by clicking on the Investor Relations ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah ... brief providing a summary of the 2015 marketplace ... enrollment trends.  According to a ... Planning and Evaluation, Department of Health and Human ... enrolled in individual medical plans through the Marketplace ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Insights into the Marketplace and Individual Market Growth 2
... Meeting , , ATLANTA, Dec. ... the once-daily antiepileptic drug (AED) Keppra XR(TM) (levetiracetam) extended-release tablets ... additional dosing schedules. The data were among five studies that ... Epilepsy Society (AES) in Seattle. , ...
... Millennium: The Takeda Oncology Company today reported updated ... from the large, international Phase III VISTA(1) trial ... untreated multiple myeloma given VELCADE, melphalan and prednisone ... all patient sub-groups, including those with poor prognostic ...
Cached Medicine Technology:New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 2New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 3New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 4New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 5New Keppra XR(TM) Data Highlight Its Role for Patients with Partial-Onset Seizures 6Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 2Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 3Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 4Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 5Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma 6
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: