Navigation Links
Cell behavior in low oxygen conditions mapped
Date:2/20/2014

LIVERPOOL, UK 17 February 2014: Research at the University of Liverpool has explained how cells behave when placed in a low oxygen environment, a development that could have implications for cancer patients and other serious illnesses.

The research opens up the possibility of controlling the signals that keep cells alive, preventing the damages caused by ischemia a restriction of blood supply to tissues. It could also work to help destroy cancer cells.

When the body is deprived of adequate oxygen supply it is known as hypoxia and can cause the death of cells. This occurs in patients suffering from 'ischemia', which can lead to gangrene or paralysis.

A reduction in oxygen levels, such as that used in the new study and which mimics the situation in a tumour, causes cells to adapt to the new environment and become resistant.

The researchers from the Institute of Integrative Biology in collaboration with researchers from the Department of Mathematical Sciences at the University, subjected cells to conditions with only 1% oxygen for 20 hours, and imaged the cellular response in real-time. They then mathematically modelled the profile of the proteins which conveyed instructions telling the cells how to behave.

It has not been established before why some cells died and others lived under low oxygen conditions, but by monitoring the levels of proteins in the cells and observing how they influenced genes switching on in the cells, the researchers were able to determine the optimum conditions for keeping cells alive.

Cell biologist, Dr Violaine See, who led the project, said: "These findings could have important consequences for how we understand tumours, which are hypoxic because of the rapid cell growth which outpaces their blood supply."


'/>"/>

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Page: 1

Related medicine news :

1. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
2. Depressed moms behavior may play role in infants sleep problems
3. Experimental Drug Eases Autistic Behaviors in Mice
4. Healthy Behaviors Extend Life After Cancer, Experts Say
5. The bright side of death: Awareness of mortality can result in positive behaviors
6. Clues to Slacker Behavior Found in Brain, Study Says
7. Overly Long Pregnancies Linked to Behavioral Problems in Toddlers
8. HIV prevention measures must include behavioral strategies to work, says APA
9. Behavioral support from peers, staff lowers patients blood pressure
10. IU bisexuality studies focus on health, behavior and identity
11. 3-center study identifies main causes of unprofessional behavior among hospitalists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... NS (PRWEB) May 22, 2015 Following ... a sale agreement with US-based health brand Nature’s Way, ... Skin brand. Retention of Ascenta Skin is an integral ... is excited about this opportunity to further develop Ascenta ... , Ascenta Skin is a breakthrough, anti-aging skincare ...
(Date:5/22/2015)... 22, 2015 Family, friends, students, colleagues, ... surgical oncologist, Dr. LaSalle D. Leffall, on Monday, May ... began after Grand Rounds in the hospital’s Tower Auditorium. ... outside the auditorium, trying to keep the secret. “I’d ... he sees me, he’ll know something is up,” she ...
(Date:5/22/2015)... Power Systems is proud to announce the sponsorship ... Drobeck is in his second year of racing in the ... Missoula Fire Department in Missoula, MT. He entered the triathlon ... his career, he has had 15 1st Place finishes. In ... finishes in all seven of his 2014 races, including two ...
(Date:5/22/2015)... 22, 2015 Gateway Building Concepts is ... The services the company specialize in include decks, additions, ... pool houses and much more. , The redesigned ... owner of the company. It includes two geometrical lines ... was thought out to be used with many things ...
(Date:5/22/2015)... 2015 DMG Productions announces the upcoming ... broadcast on Friday, May 29, 2015 at 7:30 a.m. ... In this episode Innovations will explore Interstate Restoration, a ... quickly through disaster recovery and restoration. , Additionally, the ... collaboratively to develop and deliver training and education in ...
Breaking Medicine News(10 mins):Health News:Ascenta Skin President Announces Plans to Grow Brand 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:New Episode of Innovations Airing Friday, May 29, 2015 Via Discovery Channel 2
... deadlier than a heart attack, experts say, with chances for ... star Michael Jackson probably did not die on Thursday of ... sudden cardiac arrest, experts say. , It,s not yet clear ... Angeles home, but that assumption has been made by many ...
... System , , ATLANTA, June 26 ... Grady Campaign has secured $11.5 million in new donations. ... anonymous donor, will help drive a five-year plan to ... equipment, information technology and facilities that will lay the ...
... , WASHINGTON, June 26 A new report from The ... Health Services, Department of Health Policy challenges the notion that ... and finds that fraud is a system-wide problem affecting private ... of the most striking examples of fraud come from fraud ...
... enough to halt drug therapy, researchers say , FRIDAY, ... active anti-retroviral therapy (HAART) are more likely to have ... healthy patients with high blood pressure, a new study ... disease in people with high blood pressure. , The ...
... CDC researchers note , FRIDAY, June 26 (HealthDay News) ... complications if they catch the flu, yet many skip ... for Disease Control and Prevention shows. , The lack ... rates in the general population, said study co-author Dr. ...
... costs of illness and premature deaths in Appalachia related to ... the region, says Michael Hendryx, Ph.D., associate director of the ... in WVU,s Department of Community Medicine. , ... outweighs its economic benefits," Hendryx and co-author Melissa Ahern, Ph.D., ...
Cached Medicine News:Health News:Jackson's Death Puts Spotlight on Sudden Cardiac Arrest 2Health News:Jackson's Death Puts Spotlight on Sudden Cardiac Arrest 3Health News:$11.5 Million in New Support to the Greater Grady Campaign 2Health News:New Analysis Examines Fraud in Both Private and Public Health Insurance Markets 2Health News:New Analysis Examines Fraud in Both Private and Public Health Insurance Markets 3Health News:Many Adults With Asthma Are Skipping Flu Shots 2Health News:Research Examines Health Impact of Mining -- Illness, Premature Deaths Cost Appalachia Billions 2
(Date:5/22/2015)... -- According to a new market research ... Services), by Test Type (Indirect, Enzyme-based, Reactive Oxygen Species ... Users - Global Forecast to 2020", published by MarketsandMarkets, the ... $736.85 Million by 2020 from $452.36 Million in 2015, ... Browse 71 market data Tables and 90 Figures spread ...
(Date:5/22/2015)... DUBLIN , May 22, 2015 Research ... announced the addition of the "Latest Regulations ... report to their offering. This ... officially issued a guidance on international multi-center clinical ... , which has begun to be implemented on ...
(Date:5/22/2015)... May 22, 2015 Richmond ... research unit with a worldwide reputation for excellence ... frequent publications in peer reviewed medical journals. Its ... and regulators in discussions about rules for transparency ...      (Logo: http://photos.prnewswire.com/prnh/20150522/745125) , Clinical research ...
Breaking Medicine Technology:Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 42015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
... Iowa, Aug. 25 KemPharm, Inc. announced today that ... United States Patent and Trademark Office (USPTO) for its ... and Processes for Making and Using the Same", U.S. ... recently issued U.S. Patent No. 7,772,222, provides broad protection ...
... federal judge Royce C. Lamberth halting embryonic stem cell research ... necessarily for arthritis.  A key note presentation, entitled " Guided ... the Knee " will be made on November 9, 2010 ... in Atlanta. Osteoarthritis (OA) is a disease associated ...
Cached Medicine Technology:KemPharm, Inc. Receives Notice of Issuance from USPTO on Second Patent Protecting Company's ADHD Prodrug Technology 2KemPharm, Inc. Receives Notice of Issuance from USPTO on Second Patent Protecting Company's ADHD Prodrug Technology 3Embryonic Stem Cell Research in the Toilet, According to Arthritis Treatment Center 2
... shelves. Over-sized compressor. Triple pane thermal ... Self-Contained System No plumbing required. Equipped ... Year Warranty on Parts & Labor and an ... Also available as a chromatography unit which includes ...
... Digital Thermostat and Digital Display. , ... Interiorwhite anodized aluminum with 300 series stainless ... , Temperature range 0C to 10C ... , Foamed-in-place polyurethane high density cell insulation ...
... Series Large Capacity Refigerators from Taylor-Wharton enables ... biological samples at liquid-nitrogen temperature. Seven different ... capacities are available to satisfy a broad ... HCL models are also available, providing reduced ...
... Taylor-Wharton are uniquely designed to offer increased ... racks and the lower operating costs normally ... are available in four convenient sizes, offering ... 2ml vials to 4800 x 2ml vials. ...
Medicine Products: