Navigation Links
Cell Transplantation study shows bone growth from implanted tooth and dental pulp stem cells
Date:9/26/2011

Tampa, Fla. (Sept, 26 2011) Researchers in Japan have completed a study showing that stem cells derived from deciduous canine teeth and dental pulp can be grafted and produce bone regeneration between parents and offspring. Their results are published in the current issue of Cell Transplantation (20:7), now freely available on-line.

"Bone defects can occur for a number of reasons, and autogenous bone grafting - using the patient's own bone - has been a standard approach to treatment," said study corresponding author Dr. Yoichi Yamada of the Center for Genetic and Regenerative Medicine at the Nagoya University School of Medicine. "However, considering severe invasiveness in self-donor bone sites, and the limited supply of autogenous bone, alternative donor sources are needed."

The researchers note that previous studies have shown that oral and maxillofacial dental tissues contain a variety of stem cells, such as dental pulp stem cells and stem cells from deciduous teeth. Stem cells, they note, can be easily extracted from deciduous teeth, which are routinely lost in childhood and generally discarded.

"Stem cells from human exfoliated deciduous teeth were identified as a novel population of stem cells, capable of differentiating into various cell types, such as osteoblasts, odontoblasts, adipocytes and neural cells," explained Dr. Yamada.

Their study extracted deciduous teeth from canine puppies and grafted them onto parent canine mandibles as an allograft. After four weeks, bone defects were prepared on both sides of the host mandible. The newly formed bone was evaluated at two, four and eight weeks. When compared to controls, the study group demonstrated well-formed mature bone and neovascularization.

The researchers reported that stem cells derived from dental pulp "display increased immunosuppressive activity when compared to bone marrow mesenchymal cells" and will likely have "immunosuppressive activity with potential clinical applications in allogenic in vivo stem cell transplantation, particularly for calcified tissue reconstruction."

Their pre-clinical study could pave the way for stem cell therapy in othropedics and oral maxillofacial reconstruction, concluded Dr. Yamata.

"This study highlights the promise of obtaining stem cells from unusual sources, such as teeth, and their potential benefit in familial treatments for bone reconstruction" said Dr. Julio Voltarelli, professor of Clinical Medicine and Clinical Immunology at the University of Sao Pulo, Brazil, and section editor for Cell Transplantation. "Due to their potential to also become other cell types such as neural cells, it will be interesting to see what future studies reveal about the possible uses of these cells."


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. CDC Moves to Make Organ Transplantation Safer
2. Bone marrow transplantation may increase cancer resistance in patients
3. Study finds important risk factors for death/transplantation in children with heart muscle disease
4. Many more lungs suitable for transplantation
5. Angioplasty may be feasible for liver transplantation candidates with heart disease
6. Researchers work at the frontiers of islet cell transplantation
7. Patients infected with HIV have higher drop-out rate for liver transplantation
8. Does our DNA determine how well we respond to stem-cell transplantation?
9. Oncology basic research director at John Theurer Cancer Center continues transplantation research
10. Metabolic syndrome found in 52 percent of patients after liver transplantation
11. CTCs predict poor outcome from blood stem cell transplantation therapy for metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 19, 2017 , ... Mr. Noppadon Pakprot, Deputy Governor ... Thailand Health and Wellness Tourism Showcase 2017 yesterday, which unveiled the latest “Functional ... Tourism Products and Business at TAT said, “Thailand has long been recognized as ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the importance ... for individuals with hearing impairments and shares the latest innovations in hearing aid ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance ... a new charity drive to generate community support for efforts to educate the local ... and treatments for all types of cancer. , Each day in America, roughly ...
(Date:8/18/2017)... ... 2017 , ... MLM Insurance Group, a Miami area provider ... is working to support the Take Stock In Children Foundation during a regional ... The Take Stock In Children Foundation (TSC) offers guidance and assistance to low ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Emotions are sacred, valid, honored, encouraged. ... Louis-based positive education company Generation Mindful. To help change the mindset of parents and ... emotional skills, she created the Time-In Toolkit, which launched on Kickstarter 3 weeks ago ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... , July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: ... southeast Michigan by Crain,s Detroit ... private and public companies by three-year revenue growth. This year,s ... To view the complete list, visit ... 50 is an incredible triumph," said Phil Hagerman , ...
(Date:7/31/2017)... 7D Surgical, developer of ground breaking surgical navigation ... Surgical System to support its strategic sales plan in ... and Virginia.  7D Surgical has entered into an exclusive sales ... medical facilities within those markets. ... Spartan Medical Purchases ...
(Date:7/28/2017)... , July 28, 2017 EnvoyHealth, a Diplomat company, ... a program for CleverCap LITE, a technology designed to ... to deliver innovative health technology solutions and services that ... CleverCap LITE offers medication monitoring ... bottle cover: Records ...
Breaking Medicine Technology: