Navigation Links
Cell Structure Helps Direct Cancer Gene 'Switch'

The finding might help lead to new treatments, scientists say

WEDNESDAY, Nov. 14 (HealthDay News) -- U.S. scientists say they've have uncovered a biological "switch" for key genes in cancer cells.

They found that genes in cancer cells are silenced by distinct changes in the density of structures called nucleosomes within the cells.

"The study shows for the first time exactly how genes get shut down in cancer cells. It identifies what the target looks like, so that new therapies can be designed to turn them back on," study lead author Peter A. Jones, director of the USC/Norris Comprehensive Cancer Center and Distinguished Professor at the Keck School of Medicine of USC, said in a prepared statement.

According to a statement from the university, "The study showed that silencing of transcription start sites in some cancer cells involves distinct changes in nucleosomal occupancy -- or the density of nucleosomes -- in the cell."

A process called "DNA cytosine methylation -- the addition of a group of specific chemicals to a stretch of DNA that can lock or silence a gene -- may ultimately lead to [gene] silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes," the release said.

The study was published in the Nov. 13 issue of the journal Cancer Cell.

More information

The U.S. National Cancer Institute has more about cancer.

-- Robert Preidt

SOURCE: University of Southern California, news release, Nov. 12, 2007

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. HIDA Calls for Scrutiny of Group Purchasing Organization Distributor Fee Structure
2. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
3. Purdue Pharma Selects Systech to Provide Sustainable Infrastructure for Serialization
4. Smart insulin nanostructures pass feasibility test, UT study reports
5. CRC Health Group Announces Acquisition of Durhams Structure House, Weight Loss Facility
6. Fallon Community Health Plan Selects CaseNET to Enhance Care Services Infrastructure
7. Centre De Sante et de Services Sociaux Haut-Richelieu-Rouville in Quebec Selects Alcatel-Lucent and SSP Telecom to Upgrade its Communications Infrastructure
8. Novel semiconductor structure bends light wrong way -- the right direction for many applications
9. Palmer College of Chiropractic Selects Colubris Networks to Provide Wireless Infrastructure at Three U.S. Campuses
10. Pharmos Restructures Operations in Israel
11. Best Practice Database: Complimentary Excerpt of Designing Effective Brand Teams: Structure, Governance, Performance and Operations
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... HILLS, Calif. , June 23, 2016 Any ... the many challenges of the current process. Many of them ... because of the technical difficulties and high laboratory costs involved. ... have to offer it at such a high cost that ... afford it. Dr. Parsa Zadeh , founder ...
Breaking Medicine Technology: