Navigation Links
Cell Structure Helps Direct Cancer Gene 'Switch'
Date:11/14/2007

The finding might help lead to new treatments, scientists say

WEDNESDAY, Nov. 14 (HealthDay News) -- U.S. scientists say they've have uncovered a biological "switch" for key genes in cancer cells.

They found that genes in cancer cells are silenced by distinct changes in the density of structures called nucleosomes within the cells.

"The study shows for the first time exactly how genes get shut down in cancer cells. It identifies what the target looks like, so that new therapies can be designed to turn them back on," study lead author Peter A. Jones, director of the USC/Norris Comprehensive Cancer Center and Distinguished Professor at the Keck School of Medicine of USC, said in a prepared statement.

According to a statement from the university, "The study showed that silencing of transcription start sites in some cancer cells involves distinct changes in nucleosomal occupancy -- or the density of nucleosomes -- in the cell."

A process called "DNA cytosine methylation -- the addition of a group of specific chemicals to a stretch of DNA that can lock or silence a gene -- may ultimately lead to [gene] silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes," the release said.

The study was published in the Nov. 13 issue of the journal Cancer Cell.

More information

The U.S. National Cancer Institute has more about cancer.



-- Robert Preidt



SOURCE: University of Southern California, news release, Nov. 12, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. HIDA Calls for Scrutiny of Group Purchasing Organization Distributor Fee Structure
2. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
3. Purdue Pharma Selects Systech to Provide Sustainable Infrastructure for Serialization
4. Smart insulin nanostructures pass feasibility test, UT study reports
5. CRC Health Group Announces Acquisition of Durhams Structure House, Weight Loss Facility
6. Fallon Community Health Plan Selects CaseNET to Enhance Care Services Infrastructure
7. Centre De Sante et de Services Sociaux Haut-Richelieu-Rouville in Quebec Selects Alcatel-Lucent and SSP Telecom to Upgrade its Communications Infrastructure
8. Novel semiconductor structure bends light wrong way -- the right direction for many applications
9. Palmer College of Chiropractic Selects Colubris Networks to Provide Wireless Infrastructure at Three U.S. Campuses
10. Pharmos Restructures Operations in Israel
11. Best Practice Database: Complimentary Excerpt of Designing Effective Brand Teams: Structure, Governance, Performance and Operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone ... executive with extensive sequencing and genomics experience, as Vice President of North American Capital ... will be responsible for leading the sales team in the commercialization of the HTG ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: