Navigation Links
Cell Structure Helps Direct Cancer Gene 'Switch'
Date:11/14/2007

The finding might help lead to new treatments, scientists say

WEDNESDAY, Nov. 14 (HealthDay News) -- U.S. scientists say they've have uncovered a biological "switch" for key genes in cancer cells.

They found that genes in cancer cells are silenced by distinct changes in the density of structures called nucleosomes within the cells.

"The study shows for the first time exactly how genes get shut down in cancer cells. It identifies what the target looks like, so that new therapies can be designed to turn them back on," study lead author Peter A. Jones, director of the USC/Norris Comprehensive Cancer Center and Distinguished Professor at the Keck School of Medicine of USC, said in a prepared statement.

According to a statement from the university, "The study showed that silencing of transcription start sites in some cancer cells involves distinct changes in nucleosomal occupancy -- or the density of nucleosomes -- in the cell."

A process called "DNA cytosine methylation -- the addition of a group of specific chemicals to a stretch of DNA that can lock or silence a gene -- may ultimately lead to [gene] silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes," the release said.

The study was published in the Nov. 13 issue of the journal Cancer Cell.

More information

The U.S. National Cancer Institute has more about cancer.



-- Robert Preidt



SOURCE: University of Southern California, news release, Nov. 12, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. HIDA Calls for Scrutiny of Group Purchasing Organization Distributor Fee Structure
2. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
3. Purdue Pharma Selects Systech to Provide Sustainable Infrastructure for Serialization
4. Smart insulin nanostructures pass feasibility test, UT study reports
5. CRC Health Group Announces Acquisition of Durhams Structure House, Weight Loss Facility
6. Fallon Community Health Plan Selects CaseNET to Enhance Care Services Infrastructure
7. Centre De Sante et de Services Sociaux Haut-Richelieu-Rouville in Quebec Selects Alcatel-Lucent and SSP Telecom to Upgrade its Communications Infrastructure
8. Novel semiconductor structure bends light wrong way -- the right direction for many applications
9. Palmer College of Chiropractic Selects Colubris Networks to Provide Wireless Infrastructure at Three U.S. Campuses
10. Pharmos Restructures Operations in Israel
11. Best Practice Database: Complimentary Excerpt of Designing Effective Brand Teams: Structure, Governance, Performance and Operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Sam & Associates Insurance Agency, ... and related services to residents of the region, is embarking on a charity ... and wild lands. , Endangered Species International is committed to ending the anthropogenic ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... California and Nevada and LABS, Inc., announced the future opening of a CLIA ... screening and serology testing used to determine the suitability of potential organ ...
(Date:3/22/2017)... FL (PRWEB) , ... March 22, 2017 , ... An ... mosquitoes could occasionally transmit HIV, reports Leslie Norins, MD, PhD. He says ... cases of domestically transmitted Zika virus and in new infections with HIV. ...
(Date:3/22/2017)... ... March 22, 2017 , ... Intrinsic Imaging, ... therapeutic experience and operational excellence in oncology clinical trials, proudly announces today that ... treatment of non-small cell lung cancer and small cell lung cancer. , Throughout ...
(Date:3/22/2017)... Oklahoma City, OK (PRWEB) , ... March 22, ... ... firm offering insurance and financial planning services to regional families and business owners, ... provide meaningful support to young people in the area. , A growing number ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 ... company specializing in the development of innovative peptide ... and metastatic disease, today announced that it will ... Dr. Glynn Wilson , Chairman ... of the company,s business, clinical pipeline and partnering ...
(Date:3/22/2017)... March 22, 2017 Hologic, Inc. (Nasdaq: ... the acquisition of Cynosure, Inc., a leader in medical ... cash. "We are pleased to complete our ... Michael Davin and the entire Cynosure team ... growing medical aesthetics market," said Steve MacMillan , ...
(Date:3/22/2017)... TFS is pleased to announce the appointment ... , two global executive positions in Medical Affairs and Clinical Development. ... Team and will report to Dr. Montse Barceló , Chief ... ... years of medical and scientific expertise gained across leading biopharmaceutical companies ...
Breaking Medicine Technology: