Navigation Links
Cell Structure Helps Direct Cancer Gene 'Switch'
Date:11/14/2007

The finding might help lead to new treatments, scientists say

WEDNESDAY, Nov. 14 (HealthDay News) -- U.S. scientists say they've have uncovered a biological "switch" for key genes in cancer cells.

They found that genes in cancer cells are silenced by distinct changes in the density of structures called nucleosomes within the cells.

"The study shows for the first time exactly how genes get shut down in cancer cells. It identifies what the target looks like, so that new therapies can be designed to turn them back on," study lead author Peter A. Jones, director of the USC/Norris Comprehensive Cancer Center and Distinguished Professor at the Keck School of Medicine of USC, said in a prepared statement.

According to a statement from the university, "The study showed that silencing of transcription start sites in some cancer cells involves distinct changes in nucleosomal occupancy -- or the density of nucleosomes -- in the cell."

A process called "DNA cytosine methylation -- the addition of a group of specific chemicals to a stretch of DNA that can lock or silence a gene -- may ultimately lead to [gene] silencing by enabling the stable presence of nucleosomes at the start sites of cancer-related genes," the release said.

The study was published in the Nov. 13 issue of the journal Cancer Cell.

More information

The U.S. National Cancer Institute has more about cancer.



-- Robert Preidt



SOURCE: University of Southern California, news release, Nov. 12, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. HIDA Calls for Scrutiny of Group Purchasing Organization Distributor Fee Structure
2. Innocoll Agrees the Sale of its CollaRx(R) GENTAMICIN SURGICAL IMPLANT and European Sales and Marketing Infrastructure to EUSA Pharma
3. Purdue Pharma Selects Systech to Provide Sustainable Infrastructure for Serialization
4. Smart insulin nanostructures pass feasibility test, UT study reports
5. CRC Health Group Announces Acquisition of Durhams Structure House, Weight Loss Facility
6. Fallon Community Health Plan Selects CaseNET to Enhance Care Services Infrastructure
7. Centre De Sante et de Services Sociaux Haut-Richelieu-Rouville in Quebec Selects Alcatel-Lucent and SSP Telecom to Upgrade its Communications Infrastructure
8. Novel semiconductor structure bends light wrong way -- the right direction for many applications
9. Palmer College of Chiropractic Selects Colubris Networks to Provide Wireless Infrastructure at Three U.S. Campuses
10. Pharmos Restructures Operations in Israel
11. Best Practice Database: Complimentary Excerpt of Designing Effective Brand Teams: Structure, Governance, Performance and Operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... (HealthDay News) -- Unlike children, the vast majority of adults ... at mealtime, according to a new study. This ... not just Americans, researchers from Cornell University revealed. They ... or improve their eating habits make better choices. "If ... stomach," researcher Brian Wansink, director of the Cornell Food ...
(Date:7/25/2014)... 2014 (HealthDay News) -- Although cervical cancers are declining ... to human papillomavirus (HPV) are increasing, a new study ... base of the tongue and tonsils have increased over ... younger than 45, the Canadian researchers report. "The ... younger men and of anal cancer among younger women ...
(Date:7/25/2014)... that controls when genes are switched on or off ... brain to regulate metabolism, UT Southwestern Medical Center researchers ... therapies to treat obesity and diabetes, since the transcription ... appears to influence the body,s sensitivity to insulin ... to the body,s regulation of food intake and sugar ...
(Date:7/25/2014)... NH (PRWEB) July 25, 2014 Innerspire, ... has joined the company as a Creative Enrollment Specialist. ... extensive relationship building skills as well as his accomplished ... of small business clients, and to service the creative ... Additionally, Greg will work with small business owners ...
(Date:7/25/2014)... American Brain Tumor Association (ABTA) today unveiled branding of ... patient and family conference in Chicago. , “This is ... we – the first and now only national organization ... tumor research – extend our reach by engaging volunteers ... our materials and services into the hands of those ...
Breaking Medicine News(10 mins):Health News:Most Adults Are Members of 'Clean Plate Club' 2Health News:Anal, Throat Cancers on the Rise Among Young Adults, Study Finds 2Health News:Manipulating key protein in the brain holds potential against obesity and diabetes 2Health News:Innerspire, LLC Continues National Expansion 2Health News:Innerspire, LLC Continues National Expansion 3Health News:Innerspire, LLC Continues National Expansion 4Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 3
... Include 24-oz and Convenient 4-oz Travel Size Spray ... PURE ) today announced an agreement ... silver dihydrogen citrate (SDC)-based disinfectant as OneShot Plus(TM) ... Plus product line. OneShot Plus DD eliminates ...
... retire from BoardNATICK, Mass., March 2 Boston Scientific Corporation ... Board of Directors has elected John E. Sununu as a ... as a U.S. Senator from New Hampshire. He was ... Foreign Relations, and he was appointed the Congressional Representative to ...
... no harm -- from TV viewing by young children, , , MONDAY, ... a shelf full of videos claiming to be educationally stimulating for ... wallet. , A new study suggests that watching television won,t ... several hours a day. , "TV, in and of itself, ...
... Officially Launched to Provide Consumers a Free-of-Charge ... from Funeral Homes, Cremation Services and Cemeteries ... http://www.FuneralDecisions.com ) has announced the official launch ... tool for individuals seeking funeral, cremation, and ...
... System Cart Allows Easier Operation and Improved Workflow ... Traxtal Inc., the pioneer and world leader in ... newly designed system cart for the PercuNav interventional ... Booth # 322 of the Society of Interventional ...
... March 2 /PRNewswire-FirstCall/ - Bioniche Life Sciences Inc. ... today announced that the Company has amended the ... facility with Valens U.S. (formerly Laurus Master Funds). ... agreed to a near-term extension of this facility, ...
Cached Medicine News:Health News:Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer 2Health News:Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer 3Health News:Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer 4Health News:Boston Scientific Announces Election Of John Sununu To Its Board Of Directors 2Health News:Boston Scientific Announces Election Of John Sununu To Its Board Of Directors 3Health News:Boston Scientific Announces Election Of John Sununu To Its Board Of Directors 4Health News:TV Watching Doesn't Fast-Track Baby's Skills 2Health News:TV Watching Doesn't Fast-Track Baby's Skills 3Health News:Taking the Stress Out of Funeral Planning, FuneralDecisions.com Offers Consumers an Innovative Approach 2Health News:Traxtal to Introduce Next-Generation PercuNav System Cart at SIR Annual Scientific Meeting 2Health News:Bioniche Revolving Credit Facility Maturity Date Amended 2
(Date:7/25/2014)... R.I. , July 25, 2014  CVS Caremark ... a conference call on Tuesday, August 5, 2014, at ... its second quarter 2014 financial results. An ... simultaneously through the Investor Relations portion of the CVS ... webcast, visit http://info.cvscaremark.com/investors . This webcast will be ...
(Date:7/25/2014)... Cardinal Health will today name three of ... its prestigious Independent Pharmacy Best Practices Competition, during the ... nation,s largest gatherings of independent pharmacists. ... Ohio , Tennessee ... selected for implementing exceptionally creative methods that demonstrate how ...
(Date:7/25/2014)... York , July 25, 2014 ... Transparency Market Research "Global and China Insulin Market (Rapid-Acting, ... Industry Analysis, Size, Share, Growth, Trends and Forecast (Value ... was valued at USD 19.99 billion in 2012 and ... from 2013 to 2019 to reach USD 32.24 billion ...
Breaking Medicine Technology:Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 2Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 3Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 4Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 5Cardinal Health Announces Three Best Practice Winners for Leading Change in Community Pharmacy 6Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4
... Allograft is processed from 100% cortical bone, ... The graft is machined with a textured ... graft migration. The intermedulary canal accommodates autograft ... Allografts contain a relief orientation in either ...
Lumbar Allograft with Osteoactive advantage. Promotes bone formation and faster incorporation. Derived from the proven technology behind Grafton DBM. Maintains structural integrity and strength....
... Anteater Titanium Microdiscectomy System offers ... spinal surgery. The boss anteater titanium ... herniated intervertebral discs provides for less ... The retractor is designed to provide ...
Meyerding Laminectomy Retractors, self-retaining....
Medicine Products: