Navigation Links
Cell Pathway May Be Key to Lung Cancer's Spread
Date:7/3/2009

Researchers express hope that finding will lead to treatments,,

FRIDAY, July 3 (HealthDay News) -- U.S. researchers say they've found a major cellular flaw that may drive the rapid spread of relapsed lung cancer.

When caught early, lung cancer can often be treated. But most cases are not detected until the disease is well advanced. Though doctors can sometimes put the cancer into remission, the disease often springs back more virulent than ever, frequently spreading to the person's brain and bones and defying most treatments.

Now, scientists at New York's Memorial Sloan-Kettering Cancer Center are focusing on the same cellular pathway that causes colorectal cancer to develop and spread. Their work appears online today in Cell.

"This is a first step in peeling back the genetic underpinnings of lung cancer metastases," said Don Nguyen, a research associate at Sloan-Kettering. "We think most patients who relapse have this pathway."

Like all biochemical pathways, the one they've pinpointed, known as WNT/TCF, is a normal part of the cell structure and allows information to pass through different molecules in a cell, including healthy ones. Problems begin when something goes wrong with the pathway, as in the case of colorectal and adenocarcinoma lung cancers.

Scientists know that an abnormal, over-stimulated WNT/TCF pathway can trigger the development of colorectal cancer. Though WNT/TCF does not appear to play a role in creating the initial adenocarcinoma, it does seem to play a decisive role in helping the tumor spread aggressively to other organs, Nguyen said.

Sendurai A. Mani, an assistant professor of molecular pathology at the University of Texas M.D. Anderson Cancer Center, said that the report "for the first time demonstrates that lung cancer acquires the molecular traits necessary to metastasize early on by activated WNT/TCF signaling."

The team of eight researche
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Genetic pathway responsible for link between body clock disturbance and worsening arthritis
2. U-M researchers link pathway to breast cancer stem cells
3. Research reveals molecular pathway behind invasive prostate cancers
4. Set out on the Pathway to Change with the Dermatology Nurses Association
5. NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis
6. Scientists identify gene in breast cancer pathway
7. Pathway Health Services and Vocollect Healthcare Systems Announce Strategic Partnership
8. Pathway to Wisdom May Be Found in Brain Circuitry
9. GPhA Statement on Introduction of H.R. 1548, The Pathway for Biosimilars Act
10. Cell pathway on overdrive prevents cancer response to dietary restriction
11. Exploring new pathways to language

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell Pathway May Be Key to Lung Cancer's Spread
Cell Pathway May Be Key to Lung Cancer's Spread
(Date:11/6/2009)...IA, Nov. 6 In a newly-published sp...rsing calls for new hospital policies to prevent a...se of death and disability in hospitals throughout...WW) is publishing the supplement to bring attentio...medical condition of deep vein thrombosis and its ...
(Date:11/6/2009)...IA, Nov. 6 The American Academy of...l board members of Lippincott Williams & Wilki...LWW is part of Wolters Kluwer Health, a leading pr...r students, professionals, and institutions in med...my Fellows are selected based on evidence of signi...
(Date:11/6/2009)...v. 6 Lockton Benefit Group, the he...n Companies, LLC, today announced employer health ...agement in collaboration with U.S.-based healthcar...scom.com/cgi-bin/prnh/20090415/CG99351LOGO ) ,,...r to support Lockton,s clients with: ,, Health...
(Date:11/6/2009)...lay a role in boosting memories -- or forgetting t... (HealthDay News) -- Do you remember the first tim...ly don,t, but new research suggests that your brai... 5 in the journal Current Biology , researchers s...ired the objects with pleasant or unpleasant odors...
(Date:11/6/2009)...more susceptible to bronchiolitis, study finds , ... picturesque wood-burning stove ranks alongside au... respiratory condition that is the leading cause o... study finds. , "Those infants who had more exp...to show up in doctors, offices or be hospitalized ...
Breaking Medicine News(10 mins):Health News:Journal of Cardiovascular Nursing Urges Policies and Prevention To Reduce Deaths from Venous Thromboembolism 2Health News:Journal of Cardiovascular Nursing Urges Policies and Prevention To Reduce Deaths from Venous Thromboembolism 3Health News:Seven LWW Nursing Editors Recognized as Leaders by American Academy of Nursing 2Health News:Seven LWW Nursing Editors Recognized as Leaders by American Academy of Nursing 3Health News:Lockton and Concentra Working Together to Lower Healthcare Costs for Employers 2Health News:Lockton and Concentra Working Together to Lower Healthcare Costs for Employers 3Health News:New Smells 'Etched' in Brain: Study 2Health News:Wood Fires Can Harm the Youngest Lungs 2
... 2008 Newly published research conducted by the A...ngton,s Health Promotion Research Center finds the...to be successful in guiding employers to implement... control cost while improving access to affordable...
...t Association has named the editor of Circulation... mid-July, the journal is the latest in a series o...of Circulation: Journal of the American Heart Asso...rdiovascular imaging and associate professor of me...
...rcing Services Help Health Plan Improve Efficiency...Business Growth, BIRMINGHAM, Ala., June 16 DST H...ss has extended its agreement,for business process...nt administration of all lines of business,includi...
...ries 2200 is the second contract awarded to IDC in..., June 16 /PRNewswire-FirstCall/ - IDC (Imaging Dy... in the rapidly growing market for,digital radiogr...raphy (DR) systems in eight A-Class military hospi...
...oma Society,s Light The Night(R) Walk Offers Relie..., WHITE PLAINS, N.Y., June 16 High gas prices ma...l plans, but The Leukemia &,Lymphoma Society (LLS)...e fundraising can earn $50,worth of free gas for e...
...ention to Issue 14 Years Ago, Tubs Remain Signific...ICK, Mass., June 16 For years, Joe Rossi, the,pre...couldn,t figure out,why his company sold more prod...etts is our top,market for tub reglazing.", Rossi...
Other Medicine News:Health News:New study shows American Cancer Society program helps employers 2Health News:New study shows American Cancer Society program helps employers 3Health News:American Heart Association's 3rd new journal -- Circulation: Cardiovascular Imaging 2Health News:DST Health Solutions(R) and Colorado Access Extend Agreement for Business Process Outsourcing Services 2Health News:IDC implements DR systems in eight A-Class military hospitals in Pakistan 2Health News:IDC implements DR systems in eight A-Class military hospitals in Pakistan 3Health News:Get Free Gas and Help Save a Life 2Health News:LeadCheck(R) Reminds Consumers that Bathtubs are Insidious Source for Dangerous Lead 2
(Date:11/6/2009)... N.Y., Nov. 6 Repossessions and li... in the third quarter of 2009 declined as compared... Asset Management,s NasTrac Quarterly Index (NQI)....reports for both repossessions and orderly liquida...both construction and printing equipment, offering...
(Date:11/6/2009)..., N.J., Nov. 6 Derma S...ider of advanced wound care products, announced pl...re market on Monday, November 16, 2009. The Compan...cuss the results at 11:00 am EST. Interested parti...350-1684 (international), with passcode 81416481 t...
(Date:11/6/2009)...LE, Pa., Nov. 6 Philips Respironic...Control and Prevention (CDC) to raise awareness ab...eep insufficiency. The CDC,s release of the first-...fferences in sleeplessness is a milestone in quant...s a long-time educator, industry leader and sleep ...
Breaking Medicine Technology:NasTrac Quarterly Index Shows Decline in Trucking and Machine Tool Repossessions in Q3 2009 2NasTrac Quarterly Index Shows Decline in Trucking and Machine Tool Repossessions in Q3 2009 3NasTrac Quarterly Index Shows Decline in Trucking and Machine Tool Repossessions in Q3 2009 4Derma Sciences Announces Date of Its Third Quarter 2009 Earnings Release and Conference Call 2Statement by Don Spence, CEO, Philips Home Healthcare Solutions, Endorsing CDC Educational Initiatives to Raise Awareness of Sleep Deprivation 2Scientists Spot How Sugar Feeds Tumors 54950 1MN Community Measurement Launches First Of Its Kind Quality Measure For Depression Care 54948 1MN Community Measurement Launches First Of Its Kind Quality Measure For Depression Care 54948 2MN Community Measurement Launches First Of Its Kind Quality Measure For Depression Care 54948 3STAAR Surgical Reports Progress on Japanese Application for Approval of Visian 28TM 29 Implantable Collamer 28R 29 Lens 28ICL 28TM 29 29 54946 1STAAR Surgical Reports Progress on Japanese Application for Approval of Visian 28TM 29 Implantable Collamer 28R 29 Lens 28ICL 28TM 29 29 54946 2STAAR Surgical Reports Progress on Japanese Application for Approval of Visian 28TM 29 Implantable Collamer 28R 29 Lens 28ICL 28TM 29 29 54946 3STAAR Surgical Reports Progress on Japanese Application for Approval of Visian 28TM 29 Implantable Collamer 28R 29 Lens 28ICL 28TM 29 29 54946 4
...0 Valor Medical, an emerging medical,device compa...t human,implant of Neucrylate AN for treatment of ...z at the University of Tehran. The treatment was u...been approved by the University,s,Internal Ethics ...aneurysm was a type and location,that is very diff...
...FluoroPharma Inc., a company,developing breakthrou...,Positron Emission Tomography (PET) market, announ...PET, following institutional review board (IRB),ap...is a single center,open label study, designed to e...T as a PET tracer for myocardial perfusion imaging...
Other Medicine Technology:FluoroPharma Announces Commencement of Phase I Clinical Trial for BFPET(TM), Myocardial Perfusion Imaging (MPI) Tracer for Positron Emission Tomography (PET) 2
...aboratory and a worldwide leader in innovative lab...xtensive test menu of highly complex and unique me...ned by the University of Utah, ARUP Laboratories' ...versity teaching hospitals and children's hospital...
...aboratory and a worldwide leader in innovative lab...xtensive test menu of highly complex and unique me...ned by the University of Utah, ARUP Laboratories' ...versity teaching hospitals and children's hospital...
...aboratory and a worldwide leader in innovative lab...xtensive test menu of highly complex and unique me...ned by the University of Utah, ARUP Laboratories' ...versity teaching hospitals and children's hospital...
...aboratory and a worldwide leader in innovative lab...xtensive test menu of highly complex and unique me...ned by the University of Utah, ARUP Laboratories' ...versity teaching hospitals and children's hospital...
Medicine Products: