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Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients
Date:6/1/2008

njunction with clinical presentation, medical history, and other clinical indicators when assessing the immune status of any individual patient. The use of the ImmuKnow assay as described in this study has not been approved or cleared by the FDA. The company may use data from this or similar studies to support a future FDA marketing application for a similar indication.

About Cylex, Incorporated

Cylex(TM) is a privately held global life sciences company that is the leader in the development and manufacture of in vitro diagnostic products intended to illuminate immunity. ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in patient populations undergoing immunosuppressive therapy, and is increasingly being adopted at organ transplant centers throughout the US and abroad. The Company's patented technology provides an innovative platform allowing clinical researchers to simply and reproducibly measure immune cell function for the development of new diagnostics, biomarkers, and companion assays. The company is based in Columbia, MD.

(1) Tan HP, Donaldson J, Basu A, et al. 411 Living donor kidney

transplants using alemtuzumab pre-conditioning and tacrolimus

monotherapy: 5 year experience. Abstract no. 137 presented at the

American Transplant Congress, Toronto, Canada, May 30, 2008.

(2) Tan HP, Donaldson J, Basu A, et al. Rejection characteristics of 200

living donor kidney transplants using alemtuzumab induction and

tacrolimus monotherapy: 3 year follow-up. Abstract no. 221 presented

at the American Transplant Congress, Toronto, Canada, May 30, 2008.


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