Navigation Links
Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients
Date:6/1/2008

cent ELISA-PRA for anti-HLA class I and II antibodies. Immune function was determined by using the ImmuKnow assay and ELISA-PRA in 290 samples from 39 patients receiving renal transplantation. Samples were collected pre-treatment through 2,160 days post-treatment (mean 289 +/- 428 SD). For 33 patients, sequential analysis (of between 4 and 14 samples per patient) also correlated with clinical outcomes and responses to various therapies.

There was no correlation between the cell-mediated immunity (measured in nanograms of ATP per milliliter) and percent ELISA-PRA for class I or class II (R2 <0.1). However, the median ATP concentration of samples that exhibited ELISA-PRA class II < 20% (n = 203) was significantly higher than the median ATP concentration of samples (n = 87) with ELISA-PRA >20% (216 vs. 138; p = 0.0002). A similar pattern, but less significant (p = 0.07) was observed for ELISA-PRA class I.

Three different patterns were evident among the renal transplant patients:

-- Those in whom the immune function values were in a stable zone

(100-300 ng ATP/mL) with or without anti-HLA antibodies

-- Those who exhibited diminished levels of immune function (< 100 ng

ATP/mL) following treatment for mixed forms of rejection (steroid bolus

+ plasmapheresis/IVIG + MMF) with or without a change in ELISA-PRA

-- Those who displayed low immune function (< 100 ng ATP/mL) in

association with viral infections such as BK or CMV.

About ImmuKnow(R)

ImmuKnow is an immune cell function assay that can detect cell-mediated immunity (CMI) in adult patient populations undergoing immunosuppressive therapy for organ transplantation, by measuring the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation.

The ImmuKnow test is a qualitative assay and does not directly quantify the level of immunosuppression. Results of ImmuKnow assays should be used in co
'/>"/>

SOURCE Cylex, Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. St. Jude study shows how T cells machinery dials down autoimmunity
2. Video: New Autoimmunity Public Service Campaign Alerts Men About Their Autoimmune Disease Risk
3. VBI, Mayo Clinic investigate link between fungal proteins, innate immunity and asthma
4. T cell immunity enhanced by timing of interleukin-7 therapy
5. JDRF to establish an autoimmunity center at University of Colorado Denver
6. Chopped up proteins trigger autoimmunity
7. Violent sex acts boost insects immunity system
8. More Energy & Immunity With Vitamin Supplements This Winter
9. CD200 stifles anti-tumor immunity
10. Probiotics Play Critical Role in Pediatric Health and Immunity
11. LifeQuest Announces End of Immunity Health Challenge Contest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... 30, 2015 , ... The board certified otolaryngologists at Clear ... to inform potential sinus surgery patients about ear, nose, and throat (ENT) ailments ... a wide variety of ENT issues including hearing loss, ear infections, dizziness, sleep ...
(Date:6/30/2015)... ... June 30, 2015 , ... Villa Health Care ... centers in the country. To spread the word, Villa Health Care Center created ... is, indeed, worthy of five stars. While Medicare centers its rating on health ...
(Date:6/30/2015)... ... 2015 , ... The LIV Fertility Center in Puerto Vallarta is ... age to pursue egg freezing. Statistics show that 20 percent of women are waiting ... percent increase since the 1970s. , Sadly, for women who have delayed parenthood for ...
(Date:6/30/2015)... , ... June 30, 2015 , ... According to a ... 2007 to 2013 while heroin-related deaths more than tripled in the same period—leading a ... Novus Medical Detox Center , a leading Florida-based drug treatment facility, asserts that ...
(Date:6/30/2015)... Los Angeles, CA (PRWEB) , ... June 30, 2015 , ... ... Reasons You Have Acne ,” listed five triggers that most people would not ... cloths, hair care products, and toothpaste. The primary causes of acne are ...
Breaking Medicine News(10 mins):Health News:Clear Lake Medical Center ENT Launches ‘Responsive Design’ Website 2Health News:Clear Lake Medical Center ENT Launches ‘Responsive Design’ Website 3Health News:Villa Health Care Center Announces Highest Care Rating in New Video 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 4Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 5Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2
... A recently published study revealed that virological breakthrough (VBT) ... chronic hepatitis B. Nearly 40% of the VBTs found ... this retrospective study are published in the May issue ... on behalf of the American Association for the Study ...
... drug memantine submitted a supplementary analysis of study data, the ... sees proof of a benefit of the drug for cognitive ... of daily living, at least for a treatment period of ... benefit assessment of 2009. IQWiG had repeatedly called upon the ...
... Goodwin HealthDay Reporter , TUESDAY, April 26 (HealthDay ... attacks, such as clot-busting drugs and rapid angioplasty, has led ... Researchers used data from a Swedish coronary care registry ... type of deadly heart attack known as STEMI between 1996 ...
... for publication in The Endocrine Society,s Journal of Clinical ... white children with vitamin D deficiency both had higher fat ... of fat just under their skin and white children were ... internal organs. Studies in adults and children have shown ...
... , TUESDAY, April 26 (HealthDay News) -- Seniors who ... of developing Alzheimer,s disease, a new study suggests. ... house causes dementia, and other factors could explain the ... cost of isolation, said lead investigator Bryan D. James, ...
... University bioengineering students in collaboration with the Texas Heart ... to arrhythmia victims headed toward cardiac arrest. For ... created a unique pad system for automated external defibrillators ... back into a proper rhythm in an emergency. ...
Cached Medicine News:Health News:Hepatitis B virus reemerges with long-term nucleoside analog treatment 2Health News:Long struggle for appropriately processed manufacturer data leads to a new assessment of memantine 2Health News:Long struggle for appropriately processed manufacturer data leads to a new assessment of memantine 3Health News:Evidence-Based Heart Attack Care Reduces Deaths: Study 2Health News:Evidence-Based Heart Attack Care Reduces Deaths: Study 3Health News:Vitamin D deficiency is associated with different types of obesity in black and white children 2Health News:Being 'Housebound' Linked to Alzheimer's in Elderly 2Health News:Being 'Housebound' Linked to Alzheimer's in Elderly 3Health News:Unique AED pads give hearts a second chance 2
(Date:6/30/2015)... -- Inventor of ProTide technology ...   NuCana, a clinical stage biopharmaceutical company ... portfolio of novel anti-cancer medicines, today announced the appointment ... Officer. Professor McGuigan was the original inventor ... Medicinal Chemistry at the Cardiff School of Pharmacy and ...
(Date:6/30/2015)... BRUSSELS , July 1, 2015 ... proud to announce the winners of the first Ansell ... European Operating Room (O.R.) Nurses. The 2015 award, organised ... (EORNA), recognizes perioperative nurses who display exceptional skill and ... to staff education and development. Award ceremonies are taking ...
(Date:6/30/2015)... , June 30, 2015  The MEDevice San ... year, is an event dedicated to bringing medtech professionals ... issues and topics affecting the industry today. This year,s ... the challenges and opportunities facing today,s medtech professional in ... and to register for MEDevice San Diego, please visit: ...
Breaking Medicine Technology:Internationally Renowned Medicinal Chemist Professor Chris McGuigan Appointed as NuCana's Chief Scientific Officer 2Internationally Renowned Medicinal Chemist Professor Chris McGuigan Appointed as NuCana's Chief Scientific Officer 3Ansell Announces European O.R. Nurse Hero Award Winners 2Ansell Announces European O.R. Nurse Hero Award Winners 3MEDevice San Diego 2015 Attracts High-Tech Medical Industry 2
For the quantitative determination of uric acid in serum....
For determination of uric acid in serum, plasma or urine. For Hitachi 704 / 911. Available with Calibrator: Trucal U and controls: Trulab N and Trulab P....
For the quantitative determination of uric acid in serum....
For the quantitative determination of Uric Acid in serum. Linearity: 25 mg/dl....
Medicine Products: