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Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients
Date:6/1/2008

cent ELISA-PRA for anti-HLA class I and II antibodies. Immune function was determined by using the ImmuKnow assay and ELISA-PRA in 290 samples from 39 patients receiving renal transplantation. Samples were collected pre-treatment through 2,160 days post-treatment (mean 289 +/- 428 SD). For 33 patients, sequential analysis (of between 4 and 14 samples per patient) also correlated with clinical outcomes and responses to various therapies.

There was no correlation between the cell-mediated immunity (measured in nanograms of ATP per milliliter) and percent ELISA-PRA for class I or class II (R2 <0.1). However, the median ATP concentration of samples that exhibited ELISA-PRA class II < 20% (n = 203) was significantly higher than the median ATP concentration of samples (n = 87) with ELISA-PRA >20% (216 vs. 138; p = 0.0002). A similar pattern, but less significant (p = 0.07) was observed for ELISA-PRA class I.

Three different patterns were evident among the renal transplant patients:

-- Those in whom the immune function values were in a stable zone

(100-300 ng ATP/mL) with or without anti-HLA antibodies

-- Those who exhibited diminished levels of immune function (< 100 ng

ATP/mL) following treatment for mixed forms of rejection (steroid bolus

+ plasmapheresis/IVIG + MMF) with or without a change in ELISA-PRA

-- Those who displayed low immune function (< 100 ng ATP/mL) in

association with viral infections such as BK or CMV.

About ImmuKnow(R)

ImmuKnow is an immune cell function assay that can detect cell-mediated immunity (CMI) in adult patient populations undergoing immunosuppressive therapy for organ transplantation, by measuring the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation.

The ImmuKnow test is a qualitative assay and does not directly quantify the level of immunosuppression. Results of ImmuKnow assays should be used in co
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SOURCE Cylex, Incorporated
Copyright©2008 PR Newswire.
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