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Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients
Date:6/1/2008

The ImmuKnow(R) and anti-HLA antibody assays both contribute to

characterization of renal transplant patients being weaned off

immunosuppression

COLUMBIA, Md., June 1 /PRNewswire/ -- Data developed by Cylex in conjunction with the University of Pittsburgh Medical Center, and presented today at the American Transplantation Congress in Toronto, Canada, suggest that cell-mediated immunity and anti-HLA antibody assays may be independent measures of different facets of the immune response (at least in renal transplant patients).

"Cell-mediated immunity, as measured with Cylex's ImmuKnow test, may indicate the effectiveness of augmented immunosuppression and the risk of viral infections," said Brad Stewart, president of Cylex. "By contrast, levels of anti-HLA antibodies may determine the risk for antibody-mediated rejection. In renal transplant patients who are being weaned from immunosuppression, it seems that both assays may contribute independently to characterize these patients."

Researchers at the University of Pittsburgh Medical Center have independently shown that immune function, assessed using the ImmuKnow assay for cell-mediated immunity, may correlate with decreased immunosuppression in a cohort of renal transplant recipients enrolled in a protocol of immunosuppression minimization using depletion induction and monotherapy.(1) They have also determined humoral sensitization by assessing the circulating anti-HLA antibodies.(2) The current study ("Relationship between immune function and humoral sensitization in renal transplant recipients;" see abstract no. 974) was designed to assess the relationship between immune function and the level of humoral sensitization in serially matched samples.

The ImmuKnow assay of cell-mediated immunity is used to measure the degree of immune activation of CD4+ T-cell function. Circulating anti-HLA antibodies were determined by ELISA and expressed as per
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SOURCE Cylex, Incorporated
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