Navigation Links
Cell Fusions During Inflammation May Protect Neurons
Date:4/23/2008

Surprise finding could lead to new gene therapies for nervous system

WEDNESDAY, April 23 (HealthDay News) -- Chronic inflammation triggers cell fusions that may protect neurons, according to a Stanford University School of Medicine study.

In research with mice, the Stanford team found that chronic inflammation causes bone marrow-derived blood cells to migrate to the brain and fuse with a certain type of neuron 100 times more frequently than previously thought. After this fusion occurs, the blood-cell nuclei start to express previously silent, neuron-specific genes.

This surprise finding suggests that the creation of these fused cells (heterokaryons) may play a role in protecting neurons against damage, said the researchers, who added that it could help lead to cell-mediated gene therapy.

The study was published online in Nature Cell Biology.

"This finding was totally unprecedented and unexpected. We're getting hints that this might be biologically important, but we still have a lot to learn," senior author Helen Blau, director of the Baxter Laboratory in Genetic Pharmacology, said in a prepared statement.

Previous research showed that bone marrow-derived blood cells (which give risk to all the blood and immune cells in the body) did fuse with a variety of other cell types in the body. But this fusion occurred so rarely that it was believed to have little biological significance.

When inflammation causes bone marrow-derived stem cells to travel to the brain, they bind with Purkinje neurons located in the cerebellum. These neurons, which are involved in balance and motor control, form junctions between many other neurons. Purkinje neurons don't regenerate.

In this next phase of this research, Blau plans to investigate whether this kind of fusion can rescue damaged or dying Purkinje neurons.

More information

For more about neurons, visit the National Institute of Neurological Disorders and Stroke.



-- Robert Preidt



SOURCE: Stanford University School of Medicine, news release, April 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Transfusions of Older Blood Dont Work as Well
2. Children with sickle cell disease, silent strokes show some relief with blood transfusions
3. Study links blood transfusions to surgery complications in women
4. Controversial Anemia Drug Doesnt Cut Need for Transfusions
5. drugstore.com, inc. to Announce First Quarter 2008 Results During Conference Call on Monday, May 5, 2008 at 5:00 p.m. ET
6. Unwilling to Sit on the Sidelines: Tens of Thousands of American Diabetes Association Volunteers Honored for Their Fight Against Diabetes During National Volunteer Appreciation Week
7. Extra Pounds During and Between Pregnancies Can Pose Problems
8. Consumer Watchdog Praises CA HMO Regulators Promise to Reinstate Health Coverage for Wrongfully Cancelled Patients; Cautions That All Health Costs During Gap Must be Covered
9. Cardiac Patients Admitted During Week More Likely to Survive
10. Catholic Bishops Official Available for Interview/Comment During Popes U.S. Visit
11. BioElectronics CEO Andrew Whelan: Positioning the Company for Growth During 2008 and Beyond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 2016 , ... Stephanie Hebert Insurance Agency, serving families of ... charity campaign. As part of their ongoing community involvement program, funds are now ... children deserve a voice, and in the spirit of neighbors helping neighbors in ...
(Date:2/8/2016)... , ... February 08, 2016 , ... A man who has struggled to quit smoking, ... Laser Therapy , was determined to find solutions to his problems – and he did. ... Digest is ready to introduce his breakthrough inventions to the world and better people's ...
(Date:2/8/2016)... York, NY (PRWEB) , ... February 08, 2016 , ... ... are too much to handle, you are not alone. According to the Center for ... include heart disease, stroke, type 2 diabetes and certain types of cancer, some of ...
(Date:2/8/2016)... Hilton Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... Head and surrounding areas with a vital new community enrichment program, has teamed up ... to local women and children suffering from intimate abuse. To support all those victimized ...
(Date:2/8/2016)... ... February 08, 2016 , ... Local ... the greater Venice, FL area, has initiated a fundraiser for a two year ... just four days after Christmas. To support this beautiful child who is facing ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Cardiovascular Surgery Devices - Medical Devices Pipeline Assessment, ... report, "Cardiovascular Surgery Devices - Medical Devices Pipeline ... Devices currently in pipeline stage. ... comprehensive information on the pipeline products with comparative ... development. The report reviews major players involved in ...
(Date:2/8/2016)... 2016  Labvantage Lx, a newcomer to the ... sexual enhancement product, EnduramenT. Setting a new standard ... a patented biomedical breakthrough molecule that promotes the ... responsible for many biological functions including erectile function. ... Forgoing the use of prescription medications, scientists working ...
(Date:2/8/2016)... TOKYO and FAIRFIELD, N.J. ... (Otsuka) and Medimetriks Pharmaceuticals, Inc. (Medimetriks) today announced that ... exclusive development and commercialization rights for OPA-15406 in the ... agreement also provides manufacturing rights.  OPA-15406 is a topical, ... for atopic dermatitis. --> ...
Breaking Medicine Technology: