Navigation Links
Cell Discovery May Bring Science Closer to Diabetes Cure
Date:7/20/2009

'Sox17' gene could further pancreatic research, study suggests

MONDAY, July 20 (HealthDay News) -- In early embryonic development, a specific gene plays an important role in directing cells to become part of the pancreas or part of the biliary system, and researchers say this finding could help efforts to find a cure for type 1 diabetes.

Research in mouse embryos found that the Sox17 gene "acts like a toggle or binary switch that sets off a cascade of genetic events," the study's senior investigator, James Wells, a researcher in the developmental biology division at Cincinnati Children's Hospital Medical Center, said in a hospital news release.

"In normal embryonic development, when you have an undecided cell, if Sox17 goes one way, the cell becomes part of the biliary system," Wells explained. "If it goes the other way, the cell becomes part of the pancreas."

The discovery could prove important in guiding embryonic stem cells to become pancreatic beta cells, which scientists believe could be used to treat or cure type 1 diabetes. The disease occurs when insulin-producing beta cells in the pancreas are attacked by the immune system.

"With this study showing that turning one gene on or off in a mouse embryo instructs a cell to become pancreatic or biliary, now we'll see if that same gene, Sox17, can be used to direct an embryonic stem cell to become a biliary cell instead of a pancreatic cell," said Wells, who is also an associate professor of pediatrics at the University of Cincinnati College of Medicine. "This might be used one day to replace a diseased pancreas or bile duct in people."

The study appears in the July 21 issue of Developmental Cell.

More information

The Nemours Foundation has more about type 1 diabetes.



-- Robert Preidt



SOURCE: Cincinnati Children's Hospital Medical Center, news release, July 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. The Psychology of Frailty: An Identity Crisis Among the Elderly - Alzheimers Drug Discovery Foundations Dr. Howard Fillit to Co-Chair Symposium
2. Toronto researchers discovery points to a new treatment avenue for acute myeloid leukemia
3. Scientists Gather to Discuss Novel Uses of Caliper Life Sciences Discovery Platforms and Technology
4. Discovery Points to Regulation of Calcium Metabolism
5. IDRI Awarded $314,500 Grant From Murdock Trust to Expand TB Drug Discovery Program
6. Asthma Discovery May Lead to Better Treatments
7. Microsoft to Showcase Clinical Trial Solutions From Discovery to Approvals at Drug Information Associations 2009 Annual Meeting
8. Gaiam and Discovery Communications Announce Exclusive Licensing Deal
9. Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
10. IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases
11. Eli Lilly and Company Announces New Drug Discovery Initiative
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell Discovery May Bring Science Closer to Diabetes Cure
(Date:2/13/2016)... City, Utah (PRWEB) , ... February 13, 2016 , ... When an Au Pair ... Parents aren’t always sure what they are in for and they are often worried things ... more than they were hoping for. This year’s Au Pair of the Year winner’s all ...
(Date:2/12/2016)... San Antonio, TX (PRWEB) , ... February 12, 2016 , ... ... of love, as expressed in Blue SKies Buddha, the biography of Rama - Dr. ... in fact a love story, the love of a Buddhist teacher for teaching and ...
(Date:2/12/2016)... ... ... Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. – 12:30 ... don’t learn from history are doomed to repeat it.” , An analysis of CDRH’s enforcement ... that takes time. , Take a close look at the warning letters the agency ...
(Date:2/12/2016)... ... ... Coco Libre, the maker of coconut water beverages with a purpose, is ... Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut Water, a ... suite, held this year at the W Hollywood Hotel, has become a pre-show “must” ...
(Date:2/12/2016)... ... , ... Every winter, someone is killed, injured or loses a home in ... part of the Allegheny Health Network, has partnered with Etna Volunteer Fire Department, ... Space” campaign. , “Space Heaters Need Space” aims to bring awareness to ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces its first delivery ... Okaloosa County Emergency Medical Services (EMS) ... and one LT2 van. Quality Emergency Vehicles in ... for the sale.  This is the latest in Demers, ongoing ... Vice President at Demers. --> Benoit LaFortune , ...
(Date:2/12/2016)... ALISO VIEJO , Kalifornien, 12. Februar 2016 ... es mit der Aufnahme von Patienten für eine ... Embolisation von Aneurysmen („WEB") speziell für die Behandlung ... Laurent Spelle , MD, Leiter der Neuroradiologie an ... , Frankreich, und Hauptprüfarzt der CLARYS-Studie hat den ...
(Date:2/12/2016)... and SEOUL, South Korea , ... and Macrogen, Inc. today announced they will form ... procedures for precision medicine in cancer. The goal ... DEPArray™ digital-sorting technology with Macrogen,s high-throughput Next Generation ... under the Clinical Laboratory Improvement Amendments (CLIA) of ...
Breaking Medicine Technology: