Navigation Links
Cell Discovery May Bring Science Closer to Diabetes Cure
Date:7/20/2009

'Sox17' gene could further pancreatic research, study suggests

MONDAY, July 20 (HealthDay News) -- In early embryonic development, a specific gene plays an important role in directing cells to become part of the pancreas or part of the biliary system, and researchers say this finding could help efforts to find a cure for type 1 diabetes.

Research in mouse embryos found that the Sox17 gene "acts like a toggle or binary switch that sets off a cascade of genetic events," the study's senior investigator, James Wells, a researcher in the developmental biology division at Cincinnati Children's Hospital Medical Center, said in a hospital news release.

"In normal embryonic development, when you have an undecided cell, if Sox17 goes one way, the cell becomes part of the biliary system," Wells explained. "If it goes the other way, the cell becomes part of the pancreas."

The discovery could prove important in guiding embryonic stem cells to become pancreatic beta cells, which scientists believe could be used to treat or cure type 1 diabetes. The disease occurs when insulin-producing beta cells in the pancreas are attacked by the immune system.

"With this study showing that turning one gene on or off in a mouse embryo instructs a cell to become pancreatic or biliary, now we'll see if that same gene, Sox17, can be used to direct an embryonic stem cell to become a biliary cell instead of a pancreatic cell," said Wells, who is also an associate professor of pediatrics at the University of Cincinnati College of Medicine. "This might be used one day to replace a diseased pancreas or bile duct in people."

The study appears in the July 21 issue of Developmental Cell.

More information

The Nemours Foundation has more about type 1 diabetes.



-- Robert Preidt



SOURCE: Cincinnati Children's Hospital Medical Center, news release, July 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. The Psychology of Frailty: An Identity Crisis Among the Elderly - Alzheimers Drug Discovery Foundations Dr. Howard Fillit to Co-Chair Symposium
2. Toronto researchers discovery points to a new treatment avenue for acute myeloid leukemia
3. Scientists Gather to Discuss Novel Uses of Caliper Life Sciences Discovery Platforms and Technology
4. Discovery Points to Regulation of Calcium Metabolism
5. IDRI Awarded $314,500 Grant From Murdock Trust to Expand TB Drug Discovery Program
6. Asthma Discovery May Lead to Better Treatments
7. Microsoft to Showcase Clinical Trial Solutions From Discovery to Approvals at Drug Information Associations 2009 Annual Meeting
8. Gaiam and Discovery Communications Announce Exclusive Licensing Deal
9. Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
10. IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases
11. Eli Lilly and Company Announces New Drug Discovery Initiative
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell Discovery May Bring Science Closer to Diabetes Cure
(Date:3/23/2017)... ... March 23, 2017 , ... The ... from the NCQA. The accreditation covers StayWell’s asthma, coronary artery disease, congestive heart ... granted to organizations that have excellent programs for the delivery and improvement of ...
(Date:3/23/2017)... ... March 23, 2017 , ... March 23, 2017 - ... to easily reprint customer invoices, bills, statements and other correspondence when they have ... needed to retrieve and print the documents and batch them for efficient handling. ...
(Date:3/23/2017)... OR (PRWEB) , ... March 23, 2017 , ... Sharon ... Water, Global Climate Change and Your Health on VoiceAmerica, recently talked on her program ... she also used the occasion to remind listeners of an important distinction. World Water ...
(Date:3/23/2017)... ... March 23, 2017 , ... Corra Group is ... competitive pricing. Verisys through its FACIS and other services maintains the ... actions. , “We are delighted to be able to offer these various products ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... New MEDDEV 2.7/1 Rev. 4 Guidance, **An FDAnews Webinar**, April 4, 2017 ... will the new EU MDR language change the way manufacturers approach CERs? ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017  Cornerstone Pharmaceuticals, Inc., a ... milestone today.  Following successful End-of-Phase I (EOP1) ... and Drug Administration (FDA), the Company has ... path forward to conduct pivotal trials of ... acute myeloid leukemia (AML) and pancreatic cancer. ...
(Date:3/23/2017)... March 23, 2017 Piramal ... Limited, anuncia el nombramiento de Stuart E. ... plataforma de servicios integrados completa para su base ... cargo clave en el crecimiento y ejecución de ... responsable de impulsar todas las actividades de desarrollo ...
(Date:3/23/2017)... Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK ) ... a Phase 1 study of MM-310 in solid tumors. ... novel taxane and targets the EphA2 receptor, a protein ... major tumor types, including prostate, ovarian, bladder, gastric, pancreatic ... study is an important step in evaluating MM-310,s safety ...
Breaking Medicine Technology: