Navigation Links
Cell-Based 'Tracking Devices' Might Help Monitor Treatments
Date:7/10/2012

By Barbara Bronson Gray
HealthDay Reporter

TUESDAY, July 10 (HealthDay News) -- Call it a fantastic voyage. Scientists have successfully found a way to inject tiny iron filings into the human body to potentially monitor medical therapies. The particles work as tracking devices that may help physicians determine if certain treatments are working.

The development of methods to track cells is critical to stem-cell and other therapies that rely on the delivery of particular cells to a target site, such as the heart or other organ, according to the authors of a small new study.

"Eventually we'll be able to prove stem cells are going where they are supposed to be and track cells going into other tissues," said Dr. David Newby, study co-author and professor and chair of cardiology at the Centre for Cardiovascular Science at the University of Edinburgh, in Scotland.

The study, published July 10 in Circulation: Cardiovascular Imaging, showed that immune cells tagged with nano-sized iron filings and injected into the bloodstream can be tracked by magnetic resonance imaging (MRI) as they move through the human body. The researchers also demonstrated that the process was safe and did not interfere with normal cell function.

A type of normal white blood cell known as macrophages ingest pathogens and cellular debris -- including the filings -- and take them along wherever they go. The iron filings are only about 20 nanometers across. In comparison, the average red blood cell is 8,000 nanometers wide.

Newby said the critical question the researchers wanted to answer was whether the tracking cells, once injected into the body, would migrate where the researchers wanted them to go. "We needed to be able to know if they wander off," he said.

The research showed it is possible to track tagged, injected cells for seven days. Because MRI technology is nonradioactive, the tracking system would not subject patients to radiation exposure, Newby noted.

The study involved two phases. First, the researchers determined that blood cells with attached iron filings moved normally, and were indeed able to survive. Twenty study volunteers participated. Some people were given injections into their thigh muscles of either unlabeled cells, iron-filing labeled cells or just the filings. Others received intravenous injections of the labeled blood cells.

To show that the tracking method could be used to facilitate the development of cell-based therapies in the future, the researchers injected one person with labeled immune blood cells, and they tracked the cells as they migrated to an inflamed area of skin on the thigh. The inflammation was caused by a Mantoux tuberculosis test, an injection just under the skin that typically becomes slightly inflamed.

"This is a pretty convincing demonstration that there's real merit to this idea of using cells as carriers," said Matthew Tirrell, a professor and Pritzker director of the Institute for Molecular Engineering, at the University of Chicago.

Tirrell said the research opens up new territory for other kinds of visualization experiments. "There are few examples of any kind of targeting particles in humans," he said. "To have the confidence and guts to do it is impressive, and I think other people will be building on this work," he said.

Newby said that the research team hopes to investigate the use of these techniques to diagnose inflammatory conditions of the heart, such as transplant rejection, myocarditis or inflammation of the heart, and sarcoidosis, where there is inflammation in multiple organs. The work may also be useful in five to 10 years in stem-cell research, he added.

More information

Visit PEW's Project on Emerging Nanotechnologies to learn more about nanotechnolgy.

SOURCES: David Newby, M.S., professor and chair of cardiology, Centre for Cardiovascular Science, University of Edinburgh, Scotland; Matthew Tirrell, professor and Pritzker director of the Institute for Molecular Engineering, University of Chicago; July 10, 2012, Circulation: Cardiovascular Imaging


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tracking Love, Lust in the Brain
2. Tracking the wave of success for Team GBs swimmers
3. AFTS Labs Partners With Physicians To Complement NY's Mandated I-STOP Tracking System For Pain Pill Prescriptions: A Recipe For A Safer Community
4. Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
5. Oakworks Medical, a Division of Oakworks Inc., Oakworks.com, Manufacturer of Medical Tables and Positioning Devices Announces ISO 13485 Certification
6. Adena Delivers Instant Health Information to Mobile Devices
7. The US Drug Watchdog Now Urges Plaintiffs Law Firms Worldwide To Contact Them About A Possible International Effort To Help Victims Of Defective Drugs Or Medical Devices
8. Magnets in iPad2 May Alter Settings on Brain Shunt Devices: Study
9. New Stool Test Might Aid in Early Detection of Colon Cancer
10. Depo-Provera Birth Control Might Raise Breast Cancer Risk
11. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell-Based 'Tracking Devices' Might Help Monitor Treatments
(Date:2/20/2017)... ... , ... The StayWell Company and VUCA Health announced ... risks, foster behavior change and improve health literacy among patients. VUCA Health, which created ... of its video capability at StayWell booth 3443 during HiMSS. , The VUCA ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... as an employee health benefit for companies that want to help members of ... providers, employees will have access to Watson’s suite of oncology offerings for insights ...
(Date:2/20/2017)... ... February 20, 2017 , ... Johns Hopkins All Children's Hospital celebrated ... topping out ceremony on Friday marked the halfway point of construction and lifting of ... Fall 2018, will serve as a center for innovation aimed at finding new discoveries ...
(Date:2/20/2017)... FL (PRWEB) , ... February 20, 2017 , ... ... gift from Constellation Brands to purchase a new ultrasound-enhanced thrombolysis machine, a state-of-the-art ... waves. The gift was facilitated by the Pepin Family Foundation. , “We greatly ...
(Date:2/19/2017)... ... 2017 , ... ProBrand Glitch is a set of 30 glitch distortion logo reveals made exclusively ... any logo with a glitch reveal in just a few clicks of a mouse. Customizable ... of each preset. Use these presets to add a uniquely animated logo to any photos ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... ORLANDO, Fla. , Feb. 20, 2017 /PRNewswire/ ... are helping physicians diagnose and treat patients with ... will provide wireless connectivity for ZywiePro, Zywie,s cardiac ... AT&T Control Center . AT&T ... accessible monitoring for those with the disease. The ...
(Date:2/20/2017)... , Feb. 20, 2017 Seal Shield LLC ... IT solution for mobile device management and disinfection, the ... Conference and Exhibition in Orlando, Fla. ... Mobile devices have become commonplace in today,s healthcare ... new set of concerns, including the disinfection and tracking ...
(Date:2/20/2017)... Feb. 20, 2017 Research and Markets has ... Freezer Market Analysis and Trends - Product (RFID refrigerators and RFID ... 2025" report to their offering. ... The Global RFID Blood Refrigerator and Freezer ... from 2015 to 2025. This industry report analyzes ...
Breaking Medicine Technology: