Navigation Links
Cell-Based 'Tracking Devices' Might Help Monitor Treatments
Date:7/10/2012

By Barbara Bronson Gray
HealthDay Reporter

TUESDAY, July 10 (HealthDay News) -- Call it a fantastic voyage. Scientists have successfully found a way to inject tiny iron filings into the human body to potentially monitor medical therapies. The particles work as tracking devices that may help physicians determine if certain treatments are working.

The development of methods to track cells is critical to stem-cell and other therapies that rely on the delivery of particular cells to a target site, such as the heart or other organ, according to the authors of a small new study.

"Eventually we'll be able to prove stem cells are going where they are supposed to be and track cells going into other tissues," said Dr. David Newby, study co-author and professor and chair of cardiology at the Centre for Cardiovascular Science at the University of Edinburgh, in Scotland.

The study, published July 10 in Circulation: Cardiovascular Imaging, showed that immune cells tagged with nano-sized iron filings and injected into the bloodstream can be tracked by magnetic resonance imaging (MRI) as they move through the human body. The researchers also demonstrated that the process was safe and did not interfere with normal cell function.

A type of normal white blood cell known as macrophages ingest pathogens and cellular debris -- including the filings -- and take them along wherever they go. The iron filings are only about 20 nanometers across. In comparison, the average red blood cell is 8,000 nanometers wide.

Newby said the critical question the researchers wanted to answer was whether the tracking cells, once injected into the body, would migrate where the researchers wanted them to go. "We needed to be able to know if they wander off," he said.

The research showed it is possible to track tagged, injected cells for seven days. Because MRI technology is nonradioactive, the tracking system would not subject patients to radiation exposure, Newby noted.

The study involved two phases. First, the researchers determined that blood cells with attached iron filings moved normally, and were indeed able to survive. Twenty study volunteers participated. Some people were given injections into their thigh muscles of either unlabeled cells, iron-filing labeled cells or just the filings. Others received intravenous injections of the labeled blood cells.

To show that the tracking method could be used to facilitate the development of cell-based therapies in the future, the researchers injected one person with labeled immune blood cells, and they tracked the cells as they migrated to an inflamed area of skin on the thigh. The inflammation was caused by a Mantoux tuberculosis test, an injection just under the skin that typically becomes slightly inflamed.

"This is a pretty convincing demonstration that there's real merit to this idea of using cells as carriers," said Matthew Tirrell, a professor and Pritzker director of the Institute for Molecular Engineering, at the University of Chicago.

Tirrell said the research opens up new territory for other kinds of visualization experiments. "There are few examples of any kind of targeting particles in humans," he said. "To have the confidence and guts to do it is impressive, and I think other people will be building on this work," he said.

Newby said that the research team hopes to investigate the use of these techniques to diagnose inflammatory conditions of the heart, such as transplant rejection, myocarditis or inflammation of the heart, and sarcoidosis, where there is inflammation in multiple organs. The work may also be useful in five to 10 years in stem-cell research, he added.

More information

Visit PEW's Project on Emerging Nanotechnologies to learn more about nanotechnolgy.

SOURCES: David Newby, M.S., professor and chair of cardiology, Centre for Cardiovascular Science, University of Edinburgh, Scotland; Matthew Tirrell, professor and Pritzker director of the Institute for Molecular Engineering, University of Chicago; July 10, 2012, Circulation: Cardiovascular Imaging


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tracking Love, Lust in the Brain
2. Tracking the wave of success for Team GBs swimmers
3. AFTS Labs Partners With Physicians To Complement NY's Mandated I-STOP Tracking System For Pain Pill Prescriptions: A Recipe For A Safer Community
4. Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy
5. Oakworks Medical, a Division of Oakworks Inc., Oakworks.com, Manufacturer of Medical Tables and Positioning Devices Announces ISO 13485 Certification
6. Adena Delivers Instant Health Information to Mobile Devices
7. The US Drug Watchdog Now Urges Plaintiffs Law Firms Worldwide To Contact Them About A Possible International Effort To Help Victims Of Defective Drugs Or Medical Devices
8. Magnets in iPad2 May Alter Settings on Brain Shunt Devices: Study
9. New Stool Test Might Aid in Early Detection of Colon Cancer
10. Depo-Provera Birth Control Might Raise Breast Cancer Risk
11. Brain Falters Near End of Life, but Games, Puzzles Might Slow Decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cell-Based 'Tracking Devices' Might Help Monitor Treatments
(Date:6/27/2016)... ... June 27, 2016 , ... ePAY ... partnership with Connance, a healthcare industry leader providing predictive analytics to optimize ... combine to provide health systems, hospitals and ambulatory surgical centers with dramatic ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
Breaking Medicine Technology: