Navigation Links
Cell 'Addiction' to Growth Factors May Help Spur Cancers
Date:12/13/2007

Study in mice shows blocking this dependence could stop disease before it starts

THURSDAY, Dec. 13 (HealthDay News) -- "Addiction" to certain growth factors contributes to the development of cancers caused by epigenetic changes, such as the inappropriate activation of a normally silent gene, scientists say.

The team of Johns Hopkins University researchers believe that blocking this addiction might help prevent cancer growth.

They compared mouse cells with only one copy of the IGF-II (insulin-like growth factor two) gene activated to mouse cells with both copies of IGF-II activated. Normally, only one copy of the IGF-II gene is activated.

In humans, activation of both IGF-II genes has been linked with a fivefold increased risk of intestinal tumors.

Mouse cells with one activated copy of the IGF-II gene responded to normal doses of IGF-II growth factor and recovered within 90 minutes. The cells with both copies of the IGF-II gene responded to the smallest doses of growth factor and stayed that way for more than 120 minutes.

Working with mice bred to develop colon cancer, the researchers then administered a drug that blocks the cell's ability to respond to IGF-II growth factor. The mice developed 70 percent fewer precancerous lesions than untreated mice.

"Finding the molecular mechanism behind cancer development allowed us to use a specific drug to actually take care of these risky cells before the animal developed cancer. It's making us think about cancer prevention in a whole new way," Dr. Andrew Feinberg, professor of medicine, oncology and molecular biology and genetics, and director of the Epigenetics Center at Hopkins, said in a prepared statement.

"If this is transferable to people, it could be really exciting," Feinberg said. "It means we might be able to do something about at-risk cells before cancer develops and treat these cells biochemically, and specifically, rather than usi
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Nice but naughty -- our addiction to chocolate
2. U of M study: Health food supplement may curb addiction of pathological gamblers
3. Joint NJ/NY Rally for Addiction Recovery to Be Hub of Events Nationwide
4. Initial reaction to nicotine can dictate addiction
5. Leaders in addiction treatment announce national ACTION campaign
6. Rat Study Gets at Root of Nicotine Addiction
7. Shopping Sprees Can Cost More Than You Think: How to Identify a Shopping Addiction
8. Brain Region Tied to Amphetamine Addiction
9. Nicotine addiction slashed in test of new cigarette smoking strategy
10. VH1 Teams Up with Dr. Drew for Celebrity Rehab With Dr. Drew, a Series Depicting the Process of Overcoming Addiction
11. Mental illness and drug addiction may co-occur due to disturbance in part of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... Boca Raton, Fl (PRWEB) , ... August 30, 2015 , ... ... and InHealth Media. Nutritional Products International and InHealth media is a global sales ... , “We are extremely pleased to continue our business relationship with Mr. Reid ...
(Date:8/30/2015)... ... August 30, 2015 , ... ... devices for the treatment of prostate cancer, has announced the roll-out of its ... the treatment center in Puerto Vallarta, Mexico. , The Sonablate® technology currently in ...
(Date:8/29/2015)... ... August 30, 2015 , ... Electronic Informed Consent for ... 3:00 p.m. EDT, http://www.fdanews.com/electronicinformedconsent , The simple fact about electronic informed ... , Clinical trial sites can now use audio, video and interactivity to ...
(Date:8/29/2015)... ... August 29, 2015 , ... It ... and protection against dribbled urine and sweat. "In order to prevent these problems, ... The EASY ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides optimal support for a male’s ...
(Date:8/29/2015)... ... ... like Toppik , Eau Thermale Avene and Bliss are now available on ... required to qualify for free standard shipping,” said Jennifer Ramirez, the public relations manager. ... the item’s selling price.” , With competitive pricing in the e-commerce market for beauty ...
Breaking Medicine News(10 mins):Health News:Nutrition Guru Continues Relationship With Renowned Health and Wellness Company 2Health News:Image Fusion Technology Combines MRI and Ultrasound Images to Treat Prostate Cancer 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 3Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 4Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2
... Leicester and the University of Ferrara in Italy have collaborated ... cancer pain without causing many of the side effects of ... 90% of cancer patients experience pain in the final year ... the use of drugs like morphine produces side effects such ...
... appendicitis are often diffuse and it can be difficult to ... disease. It may be possible to predict the severity from ... on an individual basis. This is the conclusion of a ... know what causes appendicitis. There is evidence that the cause ...
... didn,t accurately diagnose elderly Asians, study found , MONDAY, ... year by the American Diabetes Association as an effective ... of Singapore suggests that the hemoglobin A1c blood test ... , The American Diabetes Association,s current recommendation is that ...
... ... well as the degree programs, you don,t need to look too far. A comprehensive guide ... useful awaits you at EducationCenters.com. A stop shop for all your education needs, this site ... , ...
... Reza ... as Exclusive Distributor/Manufacturer for Saudi Arabia and the Middle East, , ... Newark, NJ (PRWEB) June 21, 2010 -- BioNeutral Group ... Chief Scientist, Dr. Andy Kielbania, will assist with a similar role in Steri – 7, ...
... ... Enterprise Mobile Management drives down support costs, improves performance and service quality of mobility ... has made available a complimentary copy of the report in the link below. ... (PRWEB) June 21, ...
Cached Medicine News:Health News:New drugs to relieve cancer pain 2Health News:New possibility to determine the severity of appendicitis 2Health News:Age, Race May Affect Type 2 Diabetes Screening Results 2Health News:The Epicenter of Education Information is Not Too Far Away 2Health News:BioNeutral Chief Scientist Dr. Andy Kielbania Appointed to Steri - 7 for Expanded Role 2Health News:BioNeutral Chief Scientist Dr. Andy Kielbania Appointed to Steri - 7 for Expanded Role 3Health News:BioNeutral Chief Scientist Dr. Andy Kielbania Appointed to Steri - 7 for Expanded Role 4Health News:Industry Benchmark Report Finds Full Mobile Lifecycle Management and ITSM Critical to Enterprise Mobile Management 2Health News:Industry Benchmark Report Finds Full Mobile Lifecycle Management and ITSM Critical to Enterprise Mobile Management 3Health News:Industry Benchmark Report Finds Full Mobile Lifecycle Management and ITSM Critical to Enterprise Mobile Management 4
(Date:8/28/2015)... , Aug. 28, 2015  CytomX Therapeutics, Inc., a ... cancer, today announced the filing of a registration statement ... Commission (SEC) relating to a proposed initial public offering ... be offered and the price range for the offering ... its common stock under the symbol "CTMX" on the ...
(Date:8/28/2015)... 28, 2015 Research ... addition of the "12th Annual Report and ... report to their offering. The 2015 ... Capacity and Production is the most recent study ... and projected future capacity and production. The report ...
(Date:8/28/2015)... Research and Markets ... the "Investigation Report on China,s Quetiapine Market, ... Developed by AstraZeneca plc, quetiapine (under the trade ... the treatment of schizophrenia. Approved by CFDA to ... the Catalogue of Drugs for the Basic National ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 212th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production 2China Quetiapine Market Investigation Report 2010-2019 2
... COMBINATION WITH DIURETIC ACCEPTED FOR REVIEW BY,FDA- , ... 2007 -,Speedel (SWX: SPPN) today welcomed the significant ... by investigators at the 22nd Annual Scientific Meeting,and ... in,Chicago, IL, USA. These results confirm the favourable ...
... inflammation in models of,arthritis and Salmonella infection, ... -, WASHINGTON, May 21, 2007 /PRNewswire/ -- ... from two studies,that demonstrate the anti-inflammatory activity ... origin, Bifantis(R),(Bifidobacterium infantis 35624), in models of ...
Cached Medicine Technology:New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 2New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 3New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 4New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 5New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 6New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 7New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 8New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 9New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 10New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard,Therapy in Treatment of Hypertension 11New Data On the Probiotic Strain Bifantis Shows Anti-Inflammatory,Properties and Increased Health Benefits 2New Data On the Probiotic Strain Bifantis Shows Anti-Inflammatory,Properties and Increased Health Benefits 3
... The Videoscopes provide superior image ... connecting to the camera head with ... density ensures more light at the ... provide optimum image clarity and reliability.,The ...
... Passport II delivery device is the second ... C11UB. Its simple-to-use syringe technology allows one-handed ... small incision. The blue colored plunger allows ... protect the haptics during insertion. The modified ...
... for long-term transtelephonic monitoring. Simple to use, ... in order to record all pre and post ... button, the patient sends the recorded ECG over ... for immediate diagnosis. Use of Heart 2005A is ...
... IMPACs comprehensive information system designed specifically ... integrate and streamline their diagnostic, management, ... intuitive software solution. Thousands of laboratory ... have proven PowerPaths unique "case-centric model ...
Medicine Products: