Navigation Links
Cell 'Addiction' to Growth Factors May Help Spur Cancers
Date:12/13/2007

Study in mice shows blocking this dependence could stop disease before it starts

THURSDAY, Dec. 13 (HealthDay News) -- "Addiction" to certain growth factors contributes to the development of cancers caused by epigenetic changes, such as the inappropriate activation of a normally silent gene, scientists say.

The team of Johns Hopkins University researchers believe that blocking this addiction might help prevent cancer growth.

They compared mouse cells with only one copy of the IGF-II (insulin-like growth factor two) gene activated to mouse cells with both copies of IGF-II activated. Normally, only one copy of the IGF-II gene is activated.

In humans, activation of both IGF-II genes has been linked with a fivefold increased risk of intestinal tumors.

Mouse cells with one activated copy of the IGF-II gene responded to normal doses of IGF-II growth factor and recovered within 90 minutes. The cells with both copies of the IGF-II gene responded to the smallest doses of growth factor and stayed that way for more than 120 minutes.

Working with mice bred to develop colon cancer, the researchers then administered a drug that blocks the cell's ability to respond to IGF-II growth factor. The mice developed 70 percent fewer precancerous lesions than untreated mice.

"Finding the molecular mechanism behind cancer development allowed us to use a specific drug to actually take care of these risky cells before the animal developed cancer. It's making us think about cancer prevention in a whole new way," Dr. Andrew Feinberg, professor of medicine, oncology and molecular biology and genetics, and director of the Epigenetics Center at Hopkins, said in a prepared statement.

"If this is transferable to people, it could be really exciting," Feinberg said. "It means we might be able to do something about at-risk cells before cancer develops and treat these cells biochemically, and specifically, rather than using current drugs that are nonspecific and kill everything in their path."

The study was expected to be published online next week in the journal Proceedings of the National Academy of Sciences.

More information

The U.S. National Cancer Institute has more about cancer genetics.



-- Robert Preidt



SOURCE: Johns Hopkins Medicine, news release, Dec. 10, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Nice but naughty -- our addiction to chocolate
2. U of M study: Health food supplement may curb addiction of pathological gamblers
3. Joint NJ/NY Rally for Addiction Recovery to Be Hub of Events Nationwide
4. Initial reaction to nicotine can dictate addiction
5. Leaders in addiction treatment announce national ACTION campaign
6. Rat Study Gets at Root of Nicotine Addiction
7. Shopping Sprees Can Cost More Than You Think: How to Identify a Shopping Addiction
8. Brain Region Tied to Amphetamine Addiction
9. Nicotine addiction slashed in test of new cigarette smoking strategy
10. VH1 Teams Up with Dr. Drew for Celebrity Rehab With Dr. Drew, a Series Depicting the Process of Overcoming Addiction
11. Mental illness and drug addiction may co-occur due to disturbance in part of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology: