Navigation Links
Celexa May Not Help Kids With Autism
Date:6/1/2009

Study finds no benefit, and more side effects, but not all agree,,,,

MONDAY, June 1 (HealthDay News) -- In contrast to the assumptions of some doctors, new research suggests that the antidepressant Celexa does not help relieve repetitive behaviors often seen in children and teens with autism.

But the findings still need to be confirmed by other studies, and at least one autism specialist said the drug has worked well in his patients of preschool age, who are younger than those in the study.

"The jury is still out on how autism should be treated," said the specialist, Dr. Andrew Zimmerman, a pediatric neurologist and director of medical autism research at the Kennedy Krieger Institute in Baltimore.

Antidepressants known as selective serotonin reuptake inhibitors, or SSRIs, are a common treatment for autism and given to perhaps 30 percent of children with the condition, said Dr. Bryan King, lead author of the study. Other common treatments, he said, include antipsychotic drugs, which calm people who use them, and stimulants such as Ritalin, which reduce hyperactivity and impulsive behaviors.

Celexa, also known by the generic name citalopram, is lesser known than similar antidepressants such as Prozac and Paxil. But it's easier to prescribe to autistic children because it comes in a liquid form, meaning that parents don't have to force their children to take pills, said King, a researcher and director of psychiatry and behavioral medicine at Seattle Children's Hospital and the University of Washington.

Also, the drug spends less time in the body before being flushed out, making it easier for doctors to quickly adjust the dosage, he said.

King's research team assumed that Celexa reduces symptoms of autism in children, such as repetitive motions, but they wanted to understand more about its powers.

"We didn't expect it to work for everyone, but we were hoping that we'd be able to drill down into the population for whom it was very helpful and begin to identify the predictor of what a positive response would be," he said.

They randomly gave either 16.5 milligrams, on average, of Celexa or a placebo to 149 children with autism who were 5 to 17 years old. The children took the drug or fake drug for three months, and 123 of them finished the study.

The number of children who improved -- defined as not engaging in as many repetitive behaviors -- was about a third in both groups.

In other words, Celexa appeared to make no difference compared with a placebo. And children on Celexa were more likely to suffer from apparent side effects such as diarrhea, insomnia, hyperactivity and repetition of movements, the study found.

In a statement, Forest Laboratories, the maker of Celexa, said that it "was not involved in this study and therefore cannot provide comment."

The results are in the June issue of Archives of General Psychiatry.

The finding raises questions about whether similar antidepressants are also not providing benefit, or as much benefit as doctors had assumed, King said.

Zimmerman, the Baltimore autism specialist, said he's successfully treated younger autistic children, ages 3 to 5, with the drug. He added that he uses smaller doses, which appear to not create as many side effects.

"If you start at a very low dose and build it up slowly, you see improvements in mood and decreases in repetitive behaviors," he said. "The kids are more attentive."

More information

The U.S. National Institute of Neurological Disorders and Stroke has more on autism.



SOURCES: Andrew Zimmerman, M.D., pediatric neurologist and director, medical research, Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore; Bryan King, M.D., director, psychiatry and behavioral medicine, Seattle Children's Hospital, and professor, psychiatry and behavioral sciences, University of Washington, Seattle; June 1, 2009, statement, Forest Laboratories; June 2009, Archives of General Psychiatry


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Wellspring Coordinates With CA Health Insurance Plans to Pay for Autism Treatments
2. Gene Gives Clues to Why Autism More Common in Boys
3. Autism in the UK costs more than $41 billion every year, shows new research
4. National Autism Association Provides Funds to Law Enforcement Agencies in Staunton, Virginia and Summit County, Utah for Project Lifesaver Equipment
5. Education Series Offered For Parents Of Children Diagnosed With An Autism Spectrum Disorder
6. Milestones Organizations 7th Annual Autism/Aspergers Conference; Featuring: Brenda Smith Myles, Ph.D.
7. Blue Cross Reverses Position on Autism After Federal Court Litigation Intensifies
8. Blue Cross Blue Shield of Michigan Plans to Offer Customer Groups Ability to Purchase Coverage of Autism Treatment Programs that Provide Intensive Early Intervention
9. NASCAR Sprint Cup Series Race at Dover International Speedway Named the "Autism Speaks 400, presented by Heluva Good! Sour Cream Dips & Cheese"
10. Brain Anatomy Could Point to Autism
11. Steinberg Announces Senate Select Committee on Autism and Related Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Celexa May Not Help Kids With Autism
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... Maryland (PRWEB) , ... October 12, 2017 , ... ... magnetic drug delivery system that we intend to develop to enable prevention of ... can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief ... advancements to physician colleagues, skilled nursing facility medical directors and other clinicians at ... of Wound Care." , "At many of these conferences we get to educate ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
Breaking Medicine Technology: