Navigation Links
Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial
Date:5/15/2008

had the option to continue on the trial for three more months per their prior randomized arm; for those participants, a third and final broncoscopy was conducted at six months.

"In patients who had high risk features such as smoking, especially in the current smokers, we were able to see that a higher dose of Celebrex could decrease the proliferation marker KI-67 in these patients, as seen through their bronchial epithelium," said Kim. "We are encouraged that we have a drug like Celebrex that decreases the expression of this proliferation marker."

These findings are also significant in that the study shows that serial broncoscopies are feasible, explained Kim. "Although CT scanning and other imaging techniques are important, for lung cancer, it may be vital to examine actual tissue to see what the markers are doing in the actual epithelium of the lung so as to best understand if an individual has a higher or lower risk of developing lung cancer."

Celebrex is in a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs), like aspirin or ibuprofen, which work by blocking chemical enzymes that cause inflammation.

The COX-2 enzyme inside cancer cells is thought to control the synthesis of prostaglandins, which are substances believed to trigger cancer cell growth. Researchers believe that prostaglandins promote the growth of new blood vessels to feed tumors, and also protect new cancers from destruction by the body's immune system. Blocking the COX-2 enzyme may reduce the amount of prostaglandin available to cancer cells and thus repress tumor growth, says Kim.

In December 2004, M. D. Anderson voluntarily suspended the trial at the request of Pfizer and the National Cancer Institute, the funding source for the study, until further data on the drug's risk for cardiac toxicities, specifically heart attacks and strokes, could be investigated. Months later, advisors to the FDA recommended that Celebrex contin
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Celebrex, Naproxen Wont Prevent Mental Decline
2. Celebrex Plus Lipitor Could Fight Prostate Cancer
3. Celebrex-Lipitor combo may halt prostate cancer
4. Having Less Power Impairs the Mind and Ability to Get Ahead, Study Shows
5. Kids Growing Up on Grown Up Drugs: New Research Shows Treatments for Adult Ailments Rapidly Rising in Children
6. Avalere Report Shows Unapproved Prescription Drugs Dropped from CMS Formulary Reference File
7. New Survey Shows Americans Value Oral Health But Knowledge Gap Remains
8. Research shows HPV testing offers women protection for twice as long as smear testing
9. Study shows that prostate cancer increases the risk of bone fracture
10. TAXUS(R) Express(R) Stent Shows Similarly Low Re-Intervention Rates in Patients with Diabetes Compared to Non-Diabetics in ARRIVE Registry Program
11. Mayo Clinic study shows acupuncture and myofascial trigger therapy treat same pain areas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial
(Date:9/19/2014)... in infertile land, and bear many beans that are ... most legumes have a symbiotic relationship with bacteria, called ... then supply the host plant with ammonia as a ... nodules in their roots. However, if too many root ... of the plants, because the energy cost of maintaining ...
(Date:9/19/2014)... images representing various glosses and then they measured ... They found that a specific population of neurons ... to either the contrast-of-highlight, sharpness-of-highlight, or brightness of ... parameters are used as parameters when the brain ... that different parameters are represented by different populations ...
(Date:9/19/2014)... September 19, 2014 Lifeinsure.biz has ... insurance riders that can be purchased without medical examinations. ... up and make a life insurance policy more advantageous. ... find more about extra options available for a no ... without medical examinations required is simple to purchase, however ...
(Date:9/19/2014)... InventHelp, a leading inventor service company, announces ... has created an accessory designed for use with a stretcher ... transport. This invention is patented. , “Patient ... place until removed, guarding a patient’s head and upper body ... from irritating smoke or rain. The accessory would be pulled ...
(Date:9/19/2014)... York, NY (PRWEB) September 19, 2014 ... Stevie Wonder tickets for his 2014 concert tour. ... In the music business, there are a handful of artists ... Stevie Wonder. Born in Saginaw, MichIgan, Wonder has been a ... During his time in the music business, he has released ...
Breaking Medicine News(10 mins):Health News:Long-distance communication from leaves to roots 2Health News:Neurons express 'gloss' using three perceptual parameters 2Health News:No Medical Exam Life Insurance - Lifeinsure.biz Presents 5 Important Riders! 2Health News:InventHelp® Client Patents “Patient Protector” – Designed to Protect Patients During Transport 2Health News:Stevie Wonder Tickets: Ticket Down Slashes Ticket Prices in Seattle, Boston, New York, Atlanta, Chicago, Detroit, Philadelphia, Toronto, Las Vegas & Oakland 2Health News:Stevie Wonder Tickets: Ticket Down Slashes Ticket Prices in Seattle, Boston, New York, Atlanta, Chicago, Detroit, Philadelphia, Toronto, Las Vegas & Oakland 3
... and Mental Hygiene (DOHMH) has banned at least three herbal ... lead and mercury. // , ,"Though there are no ... Institute of Medicine of the National Academies recommends that certain ... million) of lead and no more than 1 ppm of ...
... lose their beauty - they merely move it from their faces ... very normal girl who was in pursuit of her dreams until ... 19th of September 1999 changed her life. She met with a ... was burnt. She lost her ears, nose, left eyelid and most ...
... to the same chromosome regions which are connected with ... which exists between alcohol consumption and smoking may // ... overlap. Environmental factors also contribute towards alcoholism. Drinking and ... the lead author of the study. As many as ...
... Rogers has won the right to fight for receiving the new ... aggressive type of breast cancer and wants to make sure that ... disease is in its early stage has meant that the primary ... already taken legal recourse for the same. Even Patricia Hewitt, the ...
... in South Australia for every 100,000 people, which is reportedly ... at 11. The amount of Government funding to NGOs which ... the country. The number of mental health disorders in South ... ,The State spending towards mental health has risen by ...
... a research headed by Dr Michael Fenech studied the damage of ... study stated that excess intake of // alcoholic beverages resulted in ... the course of the study, six men aged 21-26 stuck to ... drank 300 millilitres of either complete red wine, red wine with ...
Cached Medicine News:Health News:NY Health Dept Bans 3 Ayurveda Drugs 2Health News:The Looming Controversy Surrounding Facial Transplant 2
(Date:9/19/2014)... Sept. 19, 2014  Over 200 runners participated in ... Benefit the Radiation Oncology Institute (ROI), hosted by Radiation ... Gate Park in San Francisco.  "Donations ... CEO of Radiation Business Solutions, "but at this ... over $70,000 for the ROI this year. This surpasses ...
(Date:9/19/2014)... 2014  CytRx Corporation (Nasdaq: CYTR ), ... today announced that David J. Haen , Vice ... in the Biotech Industry Conference on Friday, September 26 th ... take place at the Millennium Broadway Hotel in ... live and archived webcast of the presentation will be ...
(Date:9/19/2014)... , September 19, 2014 Reductions ... for many years in people with diabetes type 2 ... long term benefits for the kidneys." Australian ... with type 2 diabetes leads to persistent reductions in ... The global study has found that, five ...
Breaking Medicine Technology:Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 2CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 3ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3
... Systems, Inc. (NASDAQ: DCTH ) announced today that ... agreement for the Delcath Hepatic CHEMOSAT ® Delivery system ... Oncologia ---IEO), a premier European cancer treatment and research center ... the Company will provide the IEO with logistics and clinical ...
... Reportlinker.com announces that a new ... its catalogue: , Frost & ... http://www.reportlinker.com/p0490686/Frost--Sullivan-Speaks-Candidly-with-US-Pharmacists.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pharmacies_and_Drug_Stores ... feedback provided by a healthcare pharmacist ...
Cached Medicine Technology:Delcath Announces Agreement With European Institute of Oncology for Initial Launch of Hepatic Chemosat Delivery System in the European Union 2Delcath Announces Agreement With European Institute of Oncology for Initial Launch of Hepatic Chemosat Delivery System in the European Union 3Delcath Announces Agreement With European Institute of Oncology for Initial Launch of Hepatic Chemosat Delivery System in the European Union 4Frost & Sullivan Speaks Candidly with U.S. Pharmacists 2Frost & Sullivan Speaks Candidly with U.S. Pharmacists 3
... S. typhi rapid test is a ... test employs a conation of monoclonal,antibody/colloidal ... antibody immobilized on the solid phase. ... associated Salmonella typhi (typhoid) infection with ...
The IntraStent DoubleStrut Biliary Stent represents a completely new direction in stent design. The combination of parallel struts and unique cell geometry provide unparalleled performance....
Bio-Quant, Inc. OneStep hCG InstaTest is an immunochromatographic assay designed for qualitative determination of human chorionic gonadotropin (hCG) in urine for early detection of pregnancy....
For the rapid determination of human chorionic gonadotropin (hCG) in urine and serum. The test strip is used to obtain a visual qualitative result....
Medicine Products: