Navigation Links
Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial
Date:5/15/2008

HOUSTON - Celecoxib, the anti-inflammatory medication also known by the trade name Celebrex, has proven to be safe and reduces a specific proliferation measurement of precancerous lesions in the lung, according to a study from The University of Texas M. D. Anderson Cancer Center. This finding demonstrates the significance of COX-2 inhibition toward preventing lung cancer in individuals at higher risk of developing the disease.

The study is the first large randomized trial of Celebrex in lung cancer prevention; the findings will be presented at the American Society for Clinical Oncology's (ASCO) upcoming annual meeting as an oral presentation.

"With this study, in principal, we've been able to demonstrate the importance of COX-2 and the implications on inflammation pathway in lung cancer development," said Edward Kim, M.D., assistant professor in M. D. Anderson's Department of Thoracic Head and Neck Medical Oncology. "We've also been able to demonstrate that this drug class is safe and tolerable for this patient population. As we move forward in lung cancer chemoprevention, the importance of this class of drugs cannot be ignored."

From November 2001 to September 2006, the M. D. Anderson study enrolled 212 individuals, all of whom were current or former smokers with at least a 20-pack-year smoking habit. Most participants did not have any history of cancer; however, patients with a history of cancer who had been disease-free for six months could participate. The median age of participants was 53. The study examined levels of KI-67, a biomarker associated with precancerous lung lesions.

Participants underwent a baseline broncoscopy in which six predetermined biopsies were performed. They then were randomized to receive Celebrex at either 200 milligrams (low dose) or 400 milligrams (high dose) twice a day or placebo. After three months, participants received a second broncoscopy, the primary endpoint of the trial. Patients
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Celebrex, Naproxen Wont Prevent Mental Decline
2. Celebrex Plus Lipitor Could Fight Prostate Cancer
3. Celebrex-Lipitor combo may halt prostate cancer
4. Having Less Power Impairs the Mind and Ability to Get Ahead, Study Shows
5. Kids Growing Up on Grown Up Drugs: New Research Shows Treatments for Adult Ailments Rapidly Rising in Children
6. Avalere Report Shows Unapproved Prescription Drugs Dropped from CMS Formulary Reference File
7. New Survey Shows Americans Value Oral Health But Knowledge Gap Remains
8. Research shows HPV testing offers women protection for twice as long as smear testing
9. Study shows that prostate cancer increases the risk of bone fracture
10. TAXUS(R) Express(R) Stent Shows Similarly Low Re-Intervention Rates in Patients with Diabetes Compared to Non-Diabetics in ARRIVE Registry Program
11. Mayo Clinic study shows acupuncture and myofascial trigger therapy treat same pain areas
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial
(Date:12/25/2014)... iFitDress.com, the popular online supplier of wedding dresses and special ... black one-shoulder cocktail dresses . In addition, all these ... discounted prices, up to 70% off. , The ... only. You know, we have thousands of frequent callers in ... items can visit our website for more details. The current ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Recently, ... discounts on all its wedding dresses. BellasDress has chosen ... more for gift choices for the holiday season. ... can pick suitable wedding gowns here at discount prices. ... shopping experience at its website. , “All ...
(Date:12/25/2014)... When head lice hits a home or ... to get rid of it while keeping it from taking ... now have the solution right in their neighborhood: Lice ... Troopers provides full spectrum head lice screening and treatment services ... Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South ...
(Date:12/25/2014)... (HealthDay News) -- The risk of burns from fires ... need to be extra cautious, an expert says. ... significant increase in patients coming in with burns," said ... Volunteer Firefighters Burn Center of Stony Brook University Hospital ... of joy, but if not careful, could quickly turn ...
(Date:12/25/2014)... Thompson HealthDay Reporter WEDNESDAY, ... in on a "fountain of youth" drug that can delay ... adults, a new study suggests. Seniors received a significant ... targets a genetic signaling pathway linked to aging and immune ... The experimental medication, a version of the drug rapamycin, ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3
... Delaying elective surgical procedures after a patient has been ... infectious complications and raises hospital costs, according to the ... of the Journal of the American College of ... procedures continues to be a major source of morbidity ...
... By Jenifer Goodwin HealthDay Reporter , TUESDAY, ... could greatly reduce and possibly eliminate the shortage of lungs ... The procedure -- carefully controlling the volume of air ... -- nearly doubled the number of lungs that were able ...
... and a creation of a highly sophisticated transgenic mouse, but ... a long suspected theory: Inflammation in the breast is key ... the December 15 issue of Cancer Research, the ... process within the breast itself promotes growth of breast cancer ...
... to how ventilators are used could almost double the ... international research involving a doctor at St. Michael,s Hospital., ... patient is declared brain dead and the time the ... for transplant. The study involving Dr. Arthur Slutsky, the ...
... TUESDAY, Dec. 14 (HealthDay News) -- Attending Alcoholics Anonymous ... reduce their alcohol use, a new study suggests. ... help people overcome alcohol and drug addictions. But there ... this context. The new study included more than ...
... News) -- Elderly hospital patients who survive being on a ... being discharged from hospital than those who aren,t put on ... hospitalized are about the same, says a new study. ... not survive the year. And the 30 percent who are ...
Cached Medicine News:Health News:New research finds delaying surgical procedures increases infection risk and health care costs 2Health News:New Method Might Raise Number of Donor Lungs 2Health News:New Method Might Raise Number of Donor Lungs 3Health News:Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say 2Health News:Ventilation changes could double number of lungs available for transplant: study 2Health News:Spirituality May Boost Success for Alcoholics Anonymous 2Health News:Elderly Often Disabled After Mechanical Ventilation 2
(Date:12/24/2014)... 2014 Echo Therapeutics, Inc. (NASDAQ: ... on skin permeation, continuous glucose monitoring and associated ... has been appointed Chief Executive Officer effective ... 20 years of experience in the medical device, ... served as Vice President, Business Development, Otsuka Pharmaceuticals as ...
(Date:12/24/2014)... 2014   Assurex Health, a personalized medicine ... providers for behavioral health and chronic pain conditions, ... in equity financing from new and existing investors, ... and Chief Executive Officer. The financing ... Assurex Health,s GeneSight ®  products.  GeneSight,s ...
(Date:12/24/2014)... and RALEIGH, N.C. , Dec. 23, ... International plc (NASDAQ: ENDP ) (TSX: ENL), ... ) announced today that they have submitted a New ... the U.S. Food and Drug Administration (FDA).  Buprenorphine HCl ... pain severe enough to require daily, around-the-clock, long-term opioid ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5
... Ind., Oct. 6 Hill-Rom Holdings, Inc. (NYSE: ... unanimously approved enhancements to the Company,s corporate governance ... majority voting in uncontested elections. The Board ... a majority voting standard for the election of directors in ...
... 6 CareFusion (NYSE: CFN ), a new ... rankings by independent market research firms for two of ... named number one in user satisfaction ratings in MD ... the third consecutive quarter; and CareFusion,s MedMined(TM) Services received ...
Cached Medicine Technology:Hill-Rom Announces Corporate Governance Enhancements 2Hill-Rom Announces Corporate Governance Enhancements 3Hill-Rom Announces Corporate Governance Enhancements 4CareFusion Earns Top Ranking in MD Buyline and KLAS Reports 2CareFusion Earns Top Ranking in MD Buyline and KLAS Reports 3
The LM-990A is the most completely automatic lensemeter ever created. It even measured monocular and binocular PD automatically....
... The EyeSys Vista brings new ... while retaining the quality and excellence ... products. The Vista offers eyecare practitioners ... for corneal topography that utilizes the ...
... has added the NEW Evolution electronic refractor ... The Evolution offers the convenience of a ... well below other automated refraction systems. The ... the refraction process through the handheld remote ...
Uniquely designed, the wheelchair table has dual purposes. Not only does it add a modern look to any office, it is also a heavy-duty table that will support multiple instruments, and/or easily accomm...
Medicine Products: