Navigation Links
Celebrex Appears Easier on Stomach for Arthritis Patients
Date:6/17/2010

Diclofenac plus proton pump inhibitor quadrupled risk of gastrointestinal damage, study found

THURSDAY, June 17 (HealthDay News) -- Patients who take the painkiller celecoxib for arthritis pain and inflammation are less likely to suffer gastrointestinal damage than those who take diclofenac plus omeprazole, a new study finds.

Celecoxib (Celebrex) is a cox-2 selective non-steroidal anti-inflammatory drug (NSAID), diclofenac (Voltaren) is a non-selective NSAID and omeprazole (Prilosec) is a proton pump inhibitor (PPI).

The study included 4,484 patients in 32 countries or territories who were randomly selected to receive either 200 milligrams (mg) of celecoxib twice a day (2,238 patients) or 75 mg of diclofenac slow-release plus 20 mg of omeprazole (2,246 patients) once a day.

Patients taking diclofenac plus omeprazole were more than four times more likely to suffer upper or lower gastrointestinal damage than celecoxib patients -- 3.8 percent versus 0.9 percent, respectively.

The findings, which were released online June 17 in advance of publication in a future print issue of The Lancet, should prompt a review of approaches used to reduce the risk of NSAID treatment, said the authors of the CONDOR study.

"Since guidelines recommend that selection of NSAID therapy be driven by consideration of both cardiovascular and gastrointestinal effects of treatment, CONDOR has provided new data relevant to patients requiring anti-inflammatory therapy who are at increased gastrointestinal but not increased cardiovascular risk. In this population, the gastrointestinal outcomes of a cox-2 selective NSAID were quite different to those of a non-selective NSAID plus a PPI," Francis Chan of Prince of Wales Hospital, Hong Kong Special Administrative Region, China, and Jay Goldstein of the University of Illinois at Chicago, and colleagues wrote.

"Further understanding of the cardiovascular outcomes of these two strategies requires the results of ongoing trials that have been designed directly to address that important clinical question. The findings of the CONDOR trial should encourage guideline committees to review their treatment recommendations for arthritis patients," the researchers concluded.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about arthritis.



-- Robert Preidt



SOURCE: The Lancet, news release, June 17, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Can Celebrex prevent cancer-causing colon polyps?
2. Celebrex Might Thwart Inherited Skin Cancers
3. NAMI Medical Director Honored with APA Patient Advocacy Award; Appears in CNN Health and Huffington Post Columns
4. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
5. Hospitalization Appears to Help Personality Disorder Patients
6. How health care is paid for appears to impact outcome
7. Protein Appears Key to Intestinal Balance
8. Medication appears well-tolerated, beneficial in Huntingtons disease patients
9. Ashworth College Instructor Dr. Nicole Detling Miller Appears on Colbert Report
10. Brain Damage: NFL ‘Gets It,' American Society of Anesthesiologists Still Appears ‘Asleep'
11. Traumatic brain injuries: Motor deficits can persist even after what appears to be a full recovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Celebrex Appears Easier on Stomach for Arthritis Patients
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating ... many ways they remain in the eye of the beholder, according to experts who ... of The American Journal of Managed Care. For the full issue, click here ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... PUNE, India , June 24, 2016 ... "Pen Needles Market by Type (Standard Pen Needles, Safety ... 12mm), Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase ... published by MarketsandMarkets, This report studies the market for ... is expected to reach USD 2.81 Billion by 2021 ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
Breaking Medicine Technology: