Navigation Links
Celebrex Appears Easier on Stomach for Arthritis Patients
Date:6/17/2010

Diclofenac plus proton pump inhibitor quadrupled risk of gastrointestinal damage, study found

THURSDAY, June 17 (HealthDay News) -- Patients who take the painkiller celecoxib for arthritis pain and inflammation are less likely to suffer gastrointestinal damage than those who take diclofenac plus omeprazole, a new study finds.

Celecoxib (Celebrex) is a cox-2 selective non-steroidal anti-inflammatory drug (NSAID), diclofenac (Voltaren) is a non-selective NSAID and omeprazole (Prilosec) is a proton pump inhibitor (PPI).

The study included 4,484 patients in 32 countries or territories who were randomly selected to receive either 200 milligrams (mg) of celecoxib twice a day (2,238 patients) or 75 mg of diclofenac slow-release plus 20 mg of omeprazole (2,246 patients) once a day.

Patients taking diclofenac plus omeprazole were more than four times more likely to suffer upper or lower gastrointestinal damage than celecoxib patients -- 3.8 percent versus 0.9 percent, respectively.

The findings, which were released online June 17 in advance of publication in a future print issue of The Lancet, should prompt a review of approaches used to reduce the risk of NSAID treatment, said the authors of the CONDOR study.

"Since guidelines recommend that selection of NSAID therapy be driven by consideration of both cardiovascular and gastrointestinal effects of treatment, CONDOR has provided new data relevant to patients requiring anti-inflammatory therapy who are at increased gastrointestinal but not increased cardiovascular risk. In this population, the gastrointestinal outcomes of a cox-2 selective NSAID were quite different to those of a non-selective NSAID plus a PPI," Francis Chan of Prince of Wales Hospital, Hong Kong Special Administrative Region, China, and Jay Goldstein of the University of Illinois at Chicago, and colleagues wrote.

"Further understanding of the cardiovascular outcomes of these two strategies requires the results of ongoing trials that have been designed directly to address that important clinical question. The findings of the CONDOR trial should encourage guideline committees to review their treatment recommendations for arthritis patients," the researchers concluded.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about arthritis.



-- Robert Preidt



SOURCE: The Lancet, news release, June 17, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Can Celebrex prevent cancer-causing colon polyps?
2. Celebrex Might Thwart Inherited Skin Cancers
3. NAMI Medical Director Honored with APA Patient Advocacy Award; Appears in CNN Health and Huffington Post Columns
4. Taking Flu Drugs While Pregnant Appears to Be Safe: Study
5. Hospitalization Appears to Help Personality Disorder Patients
6. How health care is paid for appears to impact outcome
7. Protein Appears Key to Intestinal Balance
8. Medication appears well-tolerated, beneficial in Huntingtons disease patients
9. Ashworth College Instructor Dr. Nicole Detling Miller Appears on Colbert Report
10. Brain Damage: NFL ‘Gets It,' American Society of Anesthesiologists Still Appears ‘Asleep'
11. Traumatic brain injuries: Motor deficits can persist even after what appears to be a full recovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Celebrex Appears Easier on Stomach for Arthritis Patients
(Date:4/23/2017)... , ... April 23, 2017 , ... ... managed services announced the achievement of Cisco Select certification and SMB specialization. ... United States. , In earning the Select Certification, Altura fulfilled the ...
(Date:4/22/2017)... Juan Capistrano (PRWEB) , ... April 22, 2017 , ... The San Juan Capistrano ... recently released a parenting report outlining the need for summer camps to provide physical activities ... The Importance of Physical Activity In Summer Camps , With an increase in specialty camps ...
(Date:4/21/2017)... ... April 21, 2017 , ... Chicago plastic surgeon, Dr. Anil R. Shah, ... is a benign bony lump located on the forehead usually attributed to a facial ... sight and pain. Dr. Shah has discovered an approach that is minimally invasive. He ...
(Date:4/21/2017)... ... April 21, 2017 , ... The adage “Show, don’t tell” applies perfectly ... in the company’s esteemed VISION House demonstration project series. Manifesting the concept of right-sized ... resources they need to live affordably and abundantly without unduly taxing the resources of ...
(Date:4/21/2017)... ... 2017 , ... The American Medical Student Association (AMSA) will ... Education, from April 24 to April 28, 2017, dedicated to increasing awareness about ... mission of AWARE is to instill a compassionate, total health approach to treating ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... BLOOMINGTON, Minn. , April 18, 2017 /PRNewswire/ ... ("Imprimis"), an ophthalmology-focused pharmaceutical company, and Cameron Ehlen ... the signing of a three-year exclusive sales representation ... a dedicated sales team to introduce Imprimis, ophthalmic ... focused in 13 states in the U.S. Midwest. Precision ...
(Date:4/18/2017)... 18, 2017 Research and Markets has ... States Molecular Imaging Equipment and Radiopharmaceuticals Market, Forecast to 2023" ... ... equipment revenues as well as growth in the number of ... value to market participants that design and manufacture molecular imaging ...
(Date:4/18/2017)... 2017 Recursion Pharmaceuticals , an emerging ... learning techniques to discover treatments for rare genetic diseases, ... as vice president of biology. Chong joins the ... Belgium , where as a principal ... high-dimensional biological approaches to the small molecule lead discovery ...
Breaking Medicine Technology: