Navigation Links
Cedars-Sinai study identifies heart-specific protein that protects against arrhythmia
Date:5/18/2014

hin each heart cell changes the genetic 'signaling' changes and the cell gets the message to make less BIN1."

Shaw said cardiologists now use ultrasound images and estimates of the amount of blood pumped out of the left ventricle with each heartbeat to gauge the health of a patient's heart, but cardiologists long have known that this 'ejection fraction' is a poor indicator of patient well-being or outcome.

"The membranes of heart cells, like other cells, recycle, and thus heart cell membranes and their associated BIN1 gets into the bloodstream. By taking a simple blood sample, we can measure what's going on in the heart. As we refine this BIN1 blood test, we believe we will be able to do a biochemical assessment of the heart cell, the myocyte," Shaw said.

Shaw and his team identified the cardiac version of BIN1, but other variations affect other parts of the body. In the brain, for example, it is associated with Alzheimer's disease; in skeletal muscle, BIN1 loss is involved in muscular dystrophy. Slight differences in the BIN1 protein occur within genetic building blocks called exons, and the cardiac version has a signature that includes exons 13 and 17. The research team found that the binding of these two particular building blocks to the myocyte's internal structural proteins creates the cardiac membrane microfolds.


'/>"/>

Contact: Sally Stewart
sally.stewart@cshs.org
310-248-6566
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cedars-Sinai stroke team earns award for improving regions quality of care
2. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
3. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
4. Cedars-Sinai Medical Center studies galaxy-exploring camera in the operating room
5. Cedars-Sinai awarded $17.8 million grant to develop ALS treatment
6. In war with superbugs, Cedars-Sinai researchers see new weapon: Immune-boosting vitamin
7. Cedars-Sinai Heart Institute awarded $1.3 million to study cardiac stem cells
8. Leading stem cell scientists to focus on diabetes, eye diseases at Cedars-Sinai symposium
9. Cedars-Sinai physician-scientist awarded $3M to study most common inherited neurological disorder
10. Cedars-Sinai Heart Institute Physician Asher Kimchi, M.D., Insurance Entrepreneur Dianne Brinson to be Honored at HeartView Global Foundation’s Second Annual Gala
11. Nobel laureate Roger Tsien, Ph.D., keynotes Cedars-Sinai nanomedicine conference March 15, 16
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Volunteers from the Church of Scientology of ... summer with massive distribution of Truth About Drugs ... volunteers on Strøget, the famous Copenhagen walking street. ... and its ambiance, some quarter of a million people ... , These activities are part of a coordinating ...
(Date:7/30/2014)... Hawley, Pennsylvania (PRWEB) July 30, 2014 ... and have contributed over $8,500 to ensure its protection. ... Resort, presents a check to the Delaware Highlands Conservancy ... Partnership program. The small $2-per-stay donations add up fast, ... future of the Upper Delaware River Region. , The ...
(Date:7/30/2014)... NJ. July 30, 2014. A new network of 25 ... Stroke Trials Network (NIH StrokeNet) is working to ... U.S. Despite advances of the last two decades, ... stroke causes death or disability for 795,000 Americans. The ... of the population. , To accelerate the pace ...
(Date:7/30/2014)... July 30, 2014 LTC Consumer, an independent, ... term care insurance, features an Instant Quote tool on its ... co-founder of LTC Consumer. Quotes are free and unlimited. , ... in only seven areas – including age, gender, and state ... within seconds (you don’t need to enter any contact information ...
(Date:7/30/2014)... NY (PRWEB) July 30, 2014 The ... school, is pleased to announce that Arianna Huffington has joined ... curriculum of the Health Coach Training Program . , ... Huffington Post, a world-renowned news and blogging site that won ... the author of fourteen books and was included on the ...
Breaking Medicine News(10 mins):Health News:Pocono Mountain Resort Guests Contribute Over $8500 to Protect Land in 6 Short Months 2Health News:Kessler funded as satellite site for NIH Stroke Trials Network 2Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 3
... calories boost lifespan , THURSDAY, July 9 (HealthDay News) -- ... the aging process in monkeys could be the best proof ... , "The big question in aging research is, ,Will caloric ... Richard Weindruch, senior author of a paper appearing in the ...
... ... , ... 9, 2009 -- MarketArt is proud to announce that it has been selected by AAMSE ... Society Executives (AAMSE) 2009 Annual Conference. , , , , ,MarketArt will provide its You ...
... China, July 9 /PRNewswire-FirstCall/ - Hard to Treat ... and as previously released on June 24, 2009, ... its ownership rights to certain intellectual property, which ... HTDS. 100% of the ownership rights are expected ...
... the Scripps Research Institute have developed an innovative technique to ... to take the place of the antibodies used in many ... Elizabeth W. Gilloon Professor and professor of chemistry, along with ... at the Scripps Research Institute and winner of the 2001 ...
... LOS ANGELES (July 8, 2009) Carole Wagner Vallianos, ... Institute at Harbor-UCLA Medical Center (LA BioMed), will be inaugurated ... Annual Meeting in Chicago on July 30. Founded in ... organization of judges, lawyers and other members of the public ...
... United States Senate Committee on Small Business and ... Olympia J. Snowe, R-Maine, today convened a roundtable ... to small businesses. Participants at the roundtable, entitled ... Perspective of Small Businesses," included U.S. Sen. Ron ...
Cached Medicine News:Health News:Lighter Meals May Bring Longer Life 2Health News:Lighter Meals May Bring Longer Life 3Health News:MarketArt to Enhance Attendee Experience at AAMSE Annual Conference 2Health News:MarketArt to Enhance Attendee Experience at AAMSE Annual Conference 3Health News:Hard To Treat Diseases (HTDS.PK) Reasserting Multi Million Dollar IP Ownership Rights 2Health News:Hard To Treat Diseases (HTDS.PK) Reasserting Multi Million Dollar IP Ownership Rights 3Health News:Caltech chemists say antibody surrogates are just a 'click' away 2Health News:Caltech chemists say antibody surrogates are just a 'click' away 3Health News:LA BioMed President and CEO will be named president of the American Judicature Society 2Health News:Landrieu, Snowe Convene Roundtable on Healthcare for Small Businesses 2Health News:Landrieu, Snowe Convene Roundtable on Healthcare for Small Businesses 3
(Date:7/30/2014)... , July 30, 2014  InnoPharma, Inc. today ... 10mg/vial (the generic equivalent of Zyprexa® injection), in Canada.  ... and disturbed behaviors in patients with schizophrenia or bipolar ... generic injectable drug, InnoPharma has entered into an agreement ... Canada will make, use, sell, market and distribute ...
(Date:7/30/2014)... Cynosure, Inc. (NASDAQ: CYNO ... non-invasive and minimally invasive applications, today announced that the Board ... and Chief Financial Officer Timothy W. Baker to ... will continue to serve as CFO and will take the ... Chairman and Chief Executive Officer. "Tim has ...
(Date:7/30/2014)... SAN DIEGO , July 30, 2014 /PRNewswire/ ... ) announced today that an article based on post-hoc analyses ... "Early Weight Loss While on Lorcaserin, Diet, and Exercise as ... in the online issue of Obesity , the official ... these analyses was to identify whether there is an early ...
Breaking Medicine Technology:InnoPharma Announces Launch of Olanzapine for Injection, 10mg/vial in Canada 2Cynosure Appoints Chief Operating Officer and Chief Financial Officer Timothy W. Baker as President 2Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 2Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 3Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 4Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 5Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 6Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 7
... Mass., Nov. 17 Decision Resources, one of the world,s ... finds that, driven by the continued dominance of opioids that ... cancer pain drug market will increase from $2.3 billion in ... France, Germany, Italy, Spain, the United Kingdom and Japan. , ...
... , DURHAM, N.C., Nov. 17 Oxygen ... the company has begun shipping Dermacyte(TM) Oxygen Concentrate Gel ... The shipments, which are going out today, cover orders ... milestone event for our company - actually shipping a ...
Cached Medicine Technology:The Cancer Pain Drug Market, Driven by the Continued Dominance of Opioids, Will Increase From $2.3 Billion in 2008 to $3.7 Billion in 2018 2Oxygen Biotherapeutics, Inc. Begins Shipping Cosmetic Product to Customers 2
Subretinal Injection Cannula, Straight; 20g (0.90) x 1" (25mm); Tip Extension: 3mm, 32g (0.23); Angled at 35°....
Silicone Oil Cannula; 16g (1.40) x 8mm....
Injection Cannula, Straight; 20g (0.90) x 1" (25mm); Tip Extension: 5mm, 30g (0.30)....
...
Medicine Products: