Navigation Links
Cedars-Sinai study: How does a 'good' protein hurt brain cells after clot-induced stroke?
Date:11/23/2011

LOS ANGELES -- The National Institutes of Health has awarded a four-year, $1.4 million grant to Cedars-Sinai's Department of Neurology to study an unexpected recent discovery: After ischemic stroke the type caused by a clogged artery but with no bleeding into the brain a normal protein that plays a positive role in blood clotting escapes intact arteries and damages healthy brain cells.

"We knew thrombin leaked out during hemorrhagic strokes those in which an artery ruptures and we knew that in large amounts it killed brain cells. But we decided to see if there was thrombin after ischemic stroke, and, surprisingly, there was a lot, and it was causing major damage to brain cells. When we injected a drug that counters the effects of thrombin, stroke symptoms got better," said Patrick D. Lyden, MD, chair of the Department of Neurology and the Carmen and Louis Warschaw Chair in Neurology at Cedars-Sinai.

He was senior author of a 2010 article in the journal Stroke that described this phenomenon and suggested possible underlying mechanisms. The new grant, he said, will let researchers delve more deeply: Where is the thrombin coming from? What kinds of cells does it kill? What factors inhibit or enhance its effects?

Lyden will continue his work with Roger Y. Tsien, a scientist at the University of California, San Diego. He is one of three winners of the 2008 Nobel Prize in chemistry for development of green fluorescent protein.

Lyden's study will use fluorescence in rats and mice to light up thrombin and follow its migration and interactions with other molecules in blood vessels and brain tissue.

This is the first NIH funding directly awarded to the Department of Neurology, evidence of its growth since Lyden's arrival in 2009. He and other researchers are also supported by other NIH grants received before he joined Cedars-Sinai.


'/>"/>
Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. TGen and Virginia G. Piper Cancer Center form drug development collaboration with Cedars-Sinai
2. Cedars-Sinai scientists, physicians to be key presenters at World Stem Cell Summit
3. Cedars-Sinai movement disorders expert on international task force for dystonia treatment
4. Latest data from Cedars-Sinai vaccine study supports immune targeting of brain tumors
5. Cedars-Sinais mobile medical clinics receive $500,000 grant from California Community Foundation
6. Cedars-Sinai to hold first annual conference on stem cell therapies for neurological disorders
7. Cedars-Sinais mobile medical clinics receive grant from George Hoag Family Foundation
8. Cedars-Sinai research team awarded $1.9 million from CIRM to develop new tools and technologies
9. Cedars-Sinai Medical Genetics Institute director honored with lifetime achievement award
10. Cedars-Sinai nano-drug hits brain-tumor target found in 2001
11. Cedars-Sinai awarded $1.9 million from CIRM to develop stem cell treatments for osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... ... the certification process to promote standards of excellence for the field of eating ... for March 22 – 25, 2018 in Orlando, Florida at the Omni Resort ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
(Date:9/25/2017)... 2017   Montrium , an industry leader ... the IQPC Trial Master Files & Inspection Readiness ... EastHORN Clinical Services has selected eTMF Connect ... management. EastHORN, a leading European contract research organization ... transparency to enable greater collaboration with sponsors, improve ...
Breaking Medicine Technology: