Navigation Links
Cedars-Sinai physician-scientist awarded $3M to study most common inherited neurological disorder
Date:12/14/2012

LOS ANGELES (Dec. 13. 2012) A Cedars-Sinai physician-scientist has been awarded a $3 million grant from the California Institute for Regenerative Medicine to study with new stem cell technology Charcot-Marie-Tooth disease, the most common inherited neurological disorder and which damages nerves that control muscles.

Robert H. Baloh, MD, PhD, director of the Neuromuscular Division of Cedars-Sinai's Department of Neurology and a member of the brain program at the Cedars-Sinai's Regenerative Medicine Institute, will lead the study of the disease, named for the three doctors who first described it in 1886. He and scientists in his Neurodegenerative Diseases Laboratory will employ induced pluripotent stem cells (iPSCs) created at the Regenerative Medicine Institute, which conducts stem cell research and produces stem cells for study at other institutions through its iPSC Core Facility.

Induced pluripotent stem cells have been stepped back, through genetic manipulations to a point where scientists can turn them into any of the body's mature cells, such as brain, blood and bone cells. This allows researchers to study a disease by reproducing it in a Petri dish; if they can learn about and correct its defective genetic makeup, they theoretically could cure the disease.

"Our studies funded by the CIRM grant will be 'preclinical' laboratory research to determine if we can generate personalized stem cell lines for individual patients," said Baloh, an expert in genetic defects and molecular mechanisms that cause neuromuscular and neurodegenerative diseases. "This would mean removing skin cells from a patient with this disease, converting them into induced pluripotent stem cells, genetically correcting them, and then transplanting them back into the patient to we hope restore normal nerve function."

More than 40 gene defects have been found to cause different forms of Charcot-Marie-Tooth disease, which most often damages the "ins
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cedars-Sinai stroke team earns award for improving regions quality of care
2. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
3. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
4. Cedars-Sinai Medical Center studies galaxy-exploring camera in the operating room
5. Cedars-Sinai awarded $17.8 million grant to develop ALS treatment
6. In war with superbugs, Cedars-Sinai researchers see new weapon: Immune-boosting vitamin
7. Cedars-Sinai Heart Institute awarded $1.3 million to study cardiac stem cells
8. Leading stem cell scientists to focus on diabetes, eye diseases at Cedars-Sinai symposium
9. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
10. $9 million grant awarded to UH to study, treat learning disabilities
11. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... your worst memories? How did it make you feel? ... negative personal experience, such as how sad you were ... distress, especially when you can,t stop thinking about it. ... about the context of the memories, rather than how ... to alleviate the negative effects of these memories, a ...
(Date:4/18/2014)... could lead to potential new treatments for breaking the ... , Fibrosis, or scarring, is a hallmark of the ... can lead to serious organ damage and, in some ... centers on findings made by Swati Bhattacharyya, PhD, research ... a specific protein plays in promoting fibrosis. , ...
(Date:4/17/2014)... most popular vaccine brands for children may not be ... some cost factors when choosing vaccines, driving the market ... to a new study by University of Illinois researchers. ... driven by numerous factors," says Sheldon H. Jacobson, a ... science and of mathematics at the U. of I. ...
(Date:4/17/2014)... In a review published in the April issue ... of The Feinstein Institute for Medical Research, says it,s ... community,s approach to treating sepsis, which kills ... , Sepsis occurs when molecules released into the bloodstream ... the body. Inflammation is necessary for maintaining good health ...
(Date:4/17/2014)... as many as 10 million older Americans suffer from ... isolation. , However, new research a project that ... for six years found that Internet use among ... more than 30 percent. , "That,s a very strong ... of telecommunication, information studies and media who led the ...
Breaking Medicine News(10 mins):Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:New clues on tissue scarring in scleroderma 2Health News:Study recalculates costs of combination vaccines 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Internet use can help ward off depression among elderly 2
... A series of new guidelines for cardiac specialists has ... receive a mechanical heart-pumping device. "The new guidelines ... circulatory support device, and how early in the process ... device," says Jeffrey A. Morgan, M.D., associate director of ...
... 15 (HealthDay News) -- U.S. scientists who completed the ... will improve the ability to diagnose and treat the ... an approach that decodes the 1 to 2 percent ... team, led by researchers at the U.S. National Institutes ...
... Kobe City University of Foreign Studies surveyed and questioned Twitter ... on the social media site two weeks after the Tohoku ... determine what benefits such a system can bring to people ... news. The researchers found that people in directly affected ...
... Meat and poultry sold in the United States is widely ... bacteria that can cause serious illnesses in humans, a new ... to S. aureus range from mild skin infections ... In the new nationwide study, researchers analyzed 136 samples ...
... FRIDAY, April 15 (HealthDay News) -- Teens who start school ... crashes, a new study finds. But starting the school ... reduce impulsiveness, another study finds. In 2008, the weekday ... Va., was about 41 percent higher than for the same ...
... when occurring with hay fever, are nine times more likely ... reveals. The study was conducted by the University ... and Monash University. Published online in the ... reported on evidence from a clinical study of around 1400 ...
Cached Medicine News:Health News:Scientists Spot Key Gene Mutations in Melanoma 2Health News:Twitter and natural disasters 2Health News:Twitter and natural disasters 3Health News:Drug-Resistant Staph Bacteria Found in Meat, Poultry Nationwide 2Health News:Drug-Resistant Staph Bacteria Found in Meat, Poultry Nationwide 3Health News:Early School Start Tied to More Teen Crashes: Study 2Health News:Childhood eczema and hay fever leads to adult allergic asthma 2
(Date:1/15/2014)... LAVAL, Quebec , Jan. 15, 2014  Valeant Pharmaceuticals ... VRX) announced that the applicable waiting period under the ... to the previously announced tender offer by its indirect ... the outstanding shares of common stock of Solta Medical, ...
(Date:1/15/2014)...  Zafgen, Inc., a leading biopharmaceutical company dedicated to ... today announced initial results from its Phase 2a ... aminopeptidase 2 (MetAP2), in patients with Prader-Willi syndrome ... results showed improvements in body weight, hunger-related behaviors, ...
(Date:1/14/2014)... Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ) ... fourth quarter of 2013 on Monday, February 3, 2014. A ... the close of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ... discuss the operating highlights and financial results for the fourth ...
Breaking Medicine Technology:Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3
... (Nasdaq: ERES ) announced today that it will ... May 2, after the market closes. After the release, the ... that day. For the conference call, interested ... or 1-412-858-4600 when calling internationally. There will be a playback ...
... April 15, 2011 Atrium Medical Corporation has provided ... Atrium University, at www.AtriumU.com .  "Atrium has been ... for our customers," said Jeff McGill, Senior Vice President ... guidelines for companies, interactions with nurses and physicians, we ...
Cached Medicine Technology:ERT Reports First Quarter 2011 Operating Results on May 2, 2011 2Atrium Provides Grant to Establish Education Web Site at AtriumU.com 2
... developed a range of Milli-Q ultrapure ... water quality requirements. Each of the ... to specifically target contaminants detrimental to ... biology and ICP-MS. The systems incorporate ...
... Millipore has developed a range ... to match specific water quality requirements. ... systems is designed to specifically target ... as HPLC, molecular biology and ICP-MS. ...
... Bridge assembly allows internal or ... cooling coil allows rapid cool-down ... within approximately 10 C of ... is only 5.7 inches wideideal ...
Inquire...
Medicine Products: