Navigation Links
Cedars-Sinai 'nano-drug' hits brain-tumor target found in 2001
Date:11/5/2010

LOS ANGELES (Nov. 4, 2010) Nine years ago, scientists at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute detected a subtle shift occurring in the molecular makeup of the most aggressive type of brain tumors, glioblastoma multiforme. With further study, they found that a specific protein called laminin-411 plays a major role in a tumor's ability to build new blood vessels to support its growth and spread. But technology did not exist then to block this protein.

Now, employing new drug-engineering technology that is part of an advanced science called nanomedicine, the research team has created a "nanobioconjugate" drug that may be given by intravenous injection and carried in the blood to target the brain tumor. It is engineered to specifically permeate the tumor cell wall, entering endosomes, mobile compartments within cells.

As endosomes mature, they grow acidic (low pH), and a chemical component of the drug triggers at this point, breaking the endosomes' membranes. Freed drugs block the tumor cell's production of laminin-411, the "malignant" protein of new tumor vessels. By its nature, the drug is nontoxic to non-tumor cells; side effects associated with conventional chemotherapy are not an issue with this class of drugs.

This approach is believed to be the first of its kind the first application of a pH-dependent endosome escape unit in drugs administered intravenously for brain cancer treatment as reported in Proceedings of the National Academy of Sciences (online). Studies in lab mice show this system allows large amounts of antitumor drug to accumulate in tumors, significantly slowing the growth of new vessels and the tumors themselves. Tumors in animals treated with the drug were 90 percent smaller than those in a control group.

Gliomas, a type of malignant brain tumors, are extremely difficult to treat. Their tendency to spread into healthy brain tissue and their ability to reappear in distant location
'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cedars-Sinai awarded $1.9 million from CIRM to develop stem cell treatments for osteoporosis
2. Cedars-Sinai Pathology and Laboratory Medicine chair recognized with 2 of the fields top honors
3. Adults demonstrate modified immune response after receiving massage, Cedars-Sinai researchers show
4. Bigge Building Cedars-Sinai New West Tower
5. Cedars-Sinai heart transplantation tip sheet
6. Cedars-Sinai Medical Center Names Beverly Hills Plastic Surgeon Dr. Andrew Cohen as Chief of the Center for Plastic and Reconstructive Surgery
7. Cedars-Sinai study examines regional use of minimally invasive repair of aneurysms
8. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
9. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
10. Texas Center for Cancer Nanomedicine targets 2 tough cancers
11. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... released a new blog post explaining the main features of ... Auto insurance quotes help many drivers find the best coverage ... an agent or visit an agency for price information. These ... http://autocarinsurancebest.com/ . , Every business who relies heavily on transportation ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television ... 32nd Annual Miami Breast Cancer Conference planned ... (PER®) , shares that “a fast-growing, virulent” cancer in ... had not followed up her clean mammogram with an ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne ... highest annual revenues in the past three years. Today, the ... dresses. , According to the sales manager of the company, ... them in 2015. This point can be reflected on the ...
(Date:1/22/2015)... WASHINGTON, DC (PRWEB) January 22, 2015 ... conditions in vulnerable communities and cause financial distress to ... report by analysts at Howard University’s Center on Race ... of dollars in economic activity, payday loans at the ...
(Date:1/22/2015)... 2015 JJsHouse.com is a famous dress online ... business announces its latest collection of wedding dresses , ... important issue is the wedding dress on your big day; ... woman’s life. Every bride wants to find the most suitable ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... is available in <A HREF=",http://chinese.eurekalert.org/zh/emb_releases/2009-06/oup-wfc060109.php,">Chinese . ... transform into pluripotent stem cells cells that, like ... type of cell in the body. It is the ... achieved using somatic cells (cells that are not sperm ...
... June 2 Beckman Coulter, Inc. (NYSE: BEC ... simplify, automate, and innovate complex biomedical tests, announces upcoming investor ... http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) , , , ... - The American Association for, ...
... CASHIERS, N.C., June 2 Typical ninth graders are worried about ... friends from middle school, or keeping up with the latest popular ... the next or other mobility issues. But Luis Magana is not ... , Although Magana was diagnosed with brain cancer almost four years ...
... to regain lost trust , TUESDAY, June 2 (HealthDay News) ... criticized for not informing the public about its inner workings, ... study how to be more transparent. , "This is ... make FDA and its processes more transparent to the public," ...
... Guests ... a unique weekend series of special events and seminars with expert panels and educative discussions ... Scottsdale, Ariz. (Vocus) -- ... for the first time ever to offer a weekend retreat focused on health and wellness. ...
... (NMI), a global leader in payment gateway technologies, announced its ... Schaumburg,s Children,s Home & Aid Family Center. , , ... said NMI,s CEO Jim McKenzie. "Children,s Home & Aid is ... chance can benefit," McKenzie added. , ...
Cached Medicine News:Health News:World first: Chinese scientists create pig stem cells 2Health News:World first: Chinese scientists create pig stem cells 3Health News:Upcoming Investor Events at The American Association for Clinical Chemistry (AACC) Annual Meeting & Clinical Lab Exposition 2Health News:The SCOOTER Store Donates Scooter to North Carolina Student With Brain Cancer 2Health News:The SCOOTER Store Donates Scooter to North Carolina Student With Brain Cancer 3Health News:FDA to Study Ways to Be More Open With Public 2Health News:FDA to Study Ways to Be More Open With Public 3Health News:The Westin Kierland Resort And Mayo Clinic Present "Well Beyond" Weekend 2Health News:The Westin Kierland Resort And Mayo Clinic Present "Well Beyond" Weekend 3Health News:The Westin Kierland Resort And Mayo Clinic Present "Well Beyond" Weekend 4Health News:Network Merchants, Inc (NMI) Founders Donate $50,000 to Schaumburg's Children's Home & Aid 2
(Date:1/22/2015)... Inc. (NYSE: RMD ) today announced results for ... was $423.0 million, a 10 percent increase compared to the ... a constant currency basis). Net income was $91.2 million, an ... 31, 2013. Diluted earnings per share for the quarter were ...
(Date:1/22/2015)... 22, 2015  Amgen (NASDAQ: AMGN ) today announced that ... results on Tuesday, Jan. 27, 2015, after the close of the ... call with the investment community at 2 p.m. PT. Participating in ... chairman and chief executive officer, and other members of Amgen,s senior ...
(Date:1/22/2015)... Institute for Clinical Research, Inc., a clinical research organization ... new textbook,  Translational Research Methods for Diabetes, Obesity and ... scientific publisher. The textbook is the first ... early phase clinical studies of new drugs for diabetes, ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... Nile Therapeutics, Inc. (Nasdaq: NLTX ), a company ... patients, today announced that, as anticipated, on November 30, 2010, ... (the "Staff") of The NASDAQ Stock Market (the "Staff Determination") ... compliance with the $1.00 minimum bid price requirement, as set ...
... Unilife Corporation ( Unilife or Company ) (Nasdaq: ... completed the A$23.1 million private placement ( Placement ), which was ... 27,228,143 CHESS Depositary Interests ( CDIs ) ( Placement CDIs ) ... in one sixth of a share of the Company,s common stock) ...
Cached Medicine Technology:Nile Therapeutics Receives NASDAQ Notice; Will Request Hearing 2Nile Therapeutics Receives NASDAQ Notice; Will Request Hearing 3Unilife Completes A$23.1 Million Private Placement 2Unilife Completes A$23.1 Million Private Placement 3Unilife Completes A$23.1 Million Private Placement 4Unilife Completes A$23.1 Million Private Placement 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: