Navigation Links
Cedars-Sinai awarded $17.8 million grant to develop ALS treatment
Date:7/27/2012

LOS ANGELES (July 26, 2012) Cedars-Sinai Regenerative Medicine Institute today was awarded a $17.8 million grant from the California Institute for Regenerative Medicine to develop stem cell treatments for patients with ALS, also known as Lou Gehrig's Disease, a progressive, fatal and currently incurable neurodegenerative disease.

The grant the largest to date from the stem cell agency to Cedars-Sinai -- will fund a project with combined stem cell and gene therapy to treat amyotrophic lateral sclerosis with stem cells found in early brain development and a protein called GDNF that promotes the survival of neurons. The stem cells alone have the potential to protect damaged motor neurons in ALS. This potential increases when combined with the additional known effects of GDNF. In the past, delivering GDNF to the brain or spinal cord has been nearly impossible because it does not cross from the blood to the tissue of the spinal cord.

"We're looking at a novel and exciting way of using stem cells as 'Trojan horses' that arrive at the sick motor neurons and delivers the protein exactly where it's needed," Clive Svendsen, PhD, director of the Regenerative Medicine Institute and leader of the project,. "Our early study indicates this approach has significant potential and we're excited to bring this treatment a step closer to helping ALS patients."

About 30,000 patients in the United States have ALS, which affects nerve cells in the brain and the spinal cord. Motor neurons connect the brain to the spinal cord and then to the muscles throughout the body. Degeneration of these motor neurons is eventually fatal to ALS patients. As the motor neurons die, the brain loses the ability to initiate and control muscle movement. Patients in later stages of the disease become paralyzed.

"For the thousands living with ALS, there is no therapy now that can cure or slow their disease," said Shlomo Melmed, MD, senior vice president of Academic Affairs, dean of the Medical Faculty and Helene A. and Philip E. Hixon Chair in Investigative Medicine. "We're grateful that this grant will allow us to vigorously pursue novel therapies and benefit ALS patients."

The Cedars-Sinai proposal involves collaborations with Emory University in Atlanta and California Pacific Medical Center, bringing together teams of scientists, neurologists, neurosurgeons and nurses to take the stem cells from animal studies, through the regulatory process of FDA approval and into an 18-patient clinical trial for ALS in four years.

Svendsen expressed his thanks to Sheryl Osborne, a San Diego-based consultant, as well as their collaborators and his research team at Cedars-Sinai.

"I am grateful for the dedication our team has shown to ALS," Svendsen said. "We have a hard road ahead, and everyone should be humbled by the aggressiveness of this devastating disease. This combined gene and cell therapy approach may be one hope to fight back. With this CIRM funding, we can now move the study forward."

The Cedars-Sinai team was among seven to receive grants today from the California state stem cell agency. The current round of $150 million in new funding is to advance projects that represent the best possible chance of producing therapies for deadly and disabling diseases and disorders. The California Institute for Regenerative Medicine was established in November 2004 with passage of Proposition 71, the California Stem Cell Research and Cures Act, providing $3 billion in funding for stem cell research at universities and research institutions. CIRM previously awarded eight grants to Cedars-Sinai for a total of $11.1 million.


'/>"/>
Contact: Nicole White
nicole.white@cshs.org
310-423-5215
Cedars-Sinai Medical Center
Source:Eurekalert  

Related medicine news :

1. Cedars-Sinai stroke team earns award for improving regions quality of care
2. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
3. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
4. Cedars-Sinai Medical Center studies galaxy-exploring camera in the operating room
5. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
6. $9 million grant awarded to UH to study, treat learning disabilities
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
10. Southeast program to fight diabetes awarded nearly $10 million by HHS
11. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cedars-Sinai awarded $17.8 million grant to develop ALS treatment
(Date:2/5/2016)... High Falls, NY & Salt Lake City, UT (PRWEB) , ... ... ... Frank Davis, Founder of Activz Whole-Food Nutrition , announced that the much-anticipated feature ... 5th on the New Really Cool Humans Amateur TV Network. , Each week, on ...
(Date:2/5/2016)... ... February 05, 2016 , ... The Muscular Dystrophy Association and ... launched the 14th annual “Appetite for a Cure” campaign on Feb. 1 to ... and related diseases that severely limit strength and mobility. , Now through ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President ... have signed a joint enrollment and degree completion agreement. The agreement, which ... baccalaureate degrees at FHU|Dickson. , The agreement allows students to be jointly ...
(Date:2/5/2016)... ... February 05, 2016 , ... US Sports Camps , official operators ... to direct high-performance kids yoga training. ChildLight Yoga Studio is centrally situated in the ... Boston. , ChildLight Yoga Studio founder Lisa Flynn expresses her excitement, “We are thrilled ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each January, ... to access the treadmills. It’s a predictable trend. After the excesses of November and ... in shape by joining gyms, starting new walking or running routines, or signing up ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... NEW YORK , Feb. 4, 2016   Bernstein ... has been filed in the United States District Court for ... of a class (the "Class") consisting of all persons or ... or the "Company") (NASDAQ: INSY ) from March 3, ... charges Insys and certain of its officers with violations of ...
(Date:2/4/2016)... , Feb. 4, 2016 Wegener ... Global Markets Direct,s, ,Wegener Polyangiitis - Pipeline ... Wegener Polyangiitis,s therapeutic pipeline. This report provides ... Polyangiitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ...
(Date:2/4/2016)... , Feb. 4, 2016 Summary ... common cancer and the most common cancer in women ... the disease exceedingly prevalent. The number of women diagnosed ... decades, but the number of deaths has declined due ... cancer treatment has been revolutionized in the past four ...
Breaking Medicine Technology: