Navigation Links
Cedars-Sinai awarded $17.8 million grant to develop ALS treatment
Date:7/27/2012

LOS ANGELES (July 26, 2012) Cedars-Sinai Regenerative Medicine Institute today was awarded a $17.8 million grant from the California Institute for Regenerative Medicine to develop stem cell treatments for patients with ALS, also known as Lou Gehrig's Disease, a progressive, fatal and currently incurable neurodegenerative disease.

The grant the largest to date from the stem cell agency to Cedars-Sinai -- will fund a project with combined stem cell and gene therapy to treat amyotrophic lateral sclerosis with stem cells found in early brain development and a protein called GDNF that promotes the survival of neurons. The stem cells alone have the potential to protect damaged motor neurons in ALS. This potential increases when combined with the additional known effects of GDNF. In the past, delivering GDNF to the brain or spinal cord has been nearly impossible because it does not cross from the blood to the tissue of the spinal cord.

"We're looking at a novel and exciting way of using stem cells as 'Trojan horses' that arrive at the sick motor neurons and delivers the protein exactly where it's needed," Clive Svendsen, PhD, director of the Regenerative Medicine Institute and leader of the project,. "Our early study indicates this approach has significant potential and we're excited to bring this treatment a step closer to helping ALS patients."

About 30,000 patients in the United States have ALS, which affects nerve cells in the brain and the spinal cord. Motor neurons connect the brain to the spinal cord and then to the muscles throughout the body. Degeneration of these motor neurons is eventually fatal to ALS patients. As the motor neurons die, the brain loses the ability to initiate and control muscle movement. Patients in later stages of the disease become paralyzed.

"For the thousands living with ALS, there is no therapy now that can cure or slow their disease," said Shlomo Melmed, MD, senior vice president of Acad
'/>"/>

Contact: Nicole White
nicole.white@cshs.org
310-423-5215
Cedars-Sinai Medical Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Cedars-Sinai stroke team earns award for improving regions quality of care
2. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
3. Cedars-Sinai researchers, with stem cells, advance understanding of spinal muscular atrophy
4. Cedars-Sinai Medical Center studies galaxy-exploring camera in the operating room
5. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
6. $9 million grant awarded to UH to study, treat learning disabilities
7. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Grant awarded to help improve problem-solving skills for deaf and hard-of-hearing students
10. Southeast program to fight diabetes awarded nearly $10 million by HHS
11. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cedars-Sinai awarded $17.8 million grant to develop ALS treatment
(Date:1/22/2015)... January 23, 2015 AngelWeddingDress, the premier ... 2015 maternity wedding dresses. View website of ... looking for maternity wedding dresses online for a bridal ... with high quality for them. Its maternity wedding dresses ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining the main ... , Auto insurance quotes help many drivers find the ... to call an agent or visit an agency for price ... website: http://autocarinsurancebest.com/ . , Every business who relies heavily ...
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
(Date:1/22/2015)... Step into a macabre world where plants hold ... Wicked Plants, the Museum’s latest featured exhibition, opens Saturday, ... and diabolical plants inside of a dilapidated, Victorian home. ... physical and neurological processes between botanicals and the human ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... principle to enable the smooth transfer of microorganisms and ... encouraging sign for Indian bioscience. But slow implementation of ... scheme to become the global hub of contract research ... a major player. , ,Discussions in mid-June between ...
... Smoking ban around the world can be materialized by increasing ... enforcing current regulations that prevent or delay youth smoking according ... to improve the lives of billions of people addicted to ... suggestion and act accordingly., , “Our research shows that ...
... people worldwide are estimated to suffer from multiple sclerosis ... in young adults, and has a significant impact on ... afford an average reduction in relapse rates of 30% ... daily to weekly., ,Data from the extension of ...
... of a bird flu pandemic has created a stir worldwide ... and urging vaccine developers to speed up the process of ... ,Representatives of more than 80 countries and international organizations met ... flu pandemic. Health officials including those from the World Health ...
... to inform you of his/her HIV status, but as far ... this. Even horrifying is the fact that you have to ... from the virus., ,The Wellington District Court, New Zealand, ... was charged with criminal nuisance after not disclosing to his ...
... have been held against, a London based leading drug ... anti-asthmatic drug, Serevent to the U.S. Food and Drug ... up for a review. This became evident last November ... needed additional warnings. , ,The Public Citizen Group ...
Cached Medicine News:Health News:Biologicals Transfer Proposal between US and Indian Biotechnology 2Health News:Lawmakers alerted on new tobacco control policies by research team 2Health News:New Hope For Patients With Relapsing Multiple Sclerosis 2Health News:Ruling On Non Disclosure Of HIV Positive Status Is Not Ethical 2Health News:FDA Mislead On Asthma Drug By GlaxoSmithKline 2
(Date:1/22/2015)... 22, 2015 Increasing sophistication among enterprise buyers of ... purchasing in 2015, says Moravia CMO, ... study by market research firm Common Sense Advisory, 15 ... their translation and localization needs. "From a language industry ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/x3hp3g/microbiology ... "Microbiology Testing/Clinical Microbiology Market by Product, Clinical Application ... report to their offering. Clinical ... for the detection of infectious diseases. The respiratory ...
(Date:1/22/2015)... , Jan. 22, 2015 The Parenteral Drug Association ... Program SM : Enabling Pharmaceutical Manufacturing,s Future. ... the following goals: , Highlight the ongoing focus ... and build practical solutions by filling known gaps in current ...
Breaking Medicine Technology:Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3PDA Launches Manufacturing Science Program(SM) 2PDA Launches Manufacturing Science Program(SM) 3