Navigation Links
Cedars-Sinai awarded $1.9 million from CIRM to develop stem cell treatments for osteoporosis
Date:10/22/2010

LOS ANGELES Oct. 21, 2010 A team of physicians and scientists from the Cedars-Sinai Regenerative Medicine Institute and Department of Surgery, led by Dan Gazit, DMD, PhD has been awarded a three-year $1.9 million grant from the California stem cell agency to fund research leading to clinical trials for what could become the first biological treatment for the most common type of bone fracture in osteoporosis patients.

The grant was announced Thursday by the California Institute of Regenerative Medicine as one of 19 Early Translation II Awards aimed at developing a new stem cell therapy for an unmet medical need or clearing up a bottleneck in the development of new therapies.

"Vertebral fractures are a common, painful problem for adults with osteoporosis and it can cause severe back pain and disabilities," said Gazit. "Currently, there are not many effective options for treatment so our goal is to develop a biological treatment that not only promotes healing but also stimulates normal bone production."

Vertebral compression fractures account for approximately 700,000 injuries in the United States each year twice as many as hip fractures. They often are a result of a severe jolt to the spine, or a weakening of the spine due to osteoporosis. Approximately 10 million Americans are diagnosed with osteoporosis, a condition that primarily affects older women and is characterized by decrease in bone mass that causes bone brittleness. Another 34 million Americans have low bone mass, which also increases vulnerability to vertebral compression fractures.

Medical therapy and research have focused mainly on prevention, but when compression fractures occur, the only medical interventions available involve injection of synthetic, non-biological material that does not absorb into tissues and remains a permanent foreign body fixture in the spine.

The grant will be used to conduct studies in which animals with osteoporosis and vertebral fractures are treated with intravenous injections of human adult stem cells and a hormone already approved by the FDA for the treatment of osteoporosis patients. The study is scheduled to begin in early 2011.

"We are excited about Dr. Gazit's research and grateful for the ongoing support from the California Institute for Regenerative Medicine," said Clive Svendsen, Ph.D. director of the Cedars-Sinai Regenerative Medicine Institute. "This grant will allow us to continue advancing the use of adult stem cells to the next level, which is towards clinical use in order to give renewed hope for a healthier quality of life to the millions diagnosed with osteoporosis and related disorders."

Bruce Gewertz, MD, chair of the Department of Surgery and vice-president for interventional services said, "in the future, innovative application of stem cells will likely be an invaluable tool for surgeons to foster healing in a wide range of musculo-skeletal injuries."


'/>"/>

Contact: Sally Stewart
Sally.stewart@cshs.org
310-248-6566
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Cedars-Sinai Pathology and Laboratory Medicine chair recognized with 2 of the fields top honors
2. Adults demonstrate modified immune response after receiving massage, Cedars-Sinai researchers show
3. Bigge Building Cedars-Sinai New West Tower
4. Cedars-Sinai heart transplantation tip sheet
5. Cedars-Sinai Medical Center Names Beverly Hills Plastic Surgeon Dr. Andrew Cohen as Chief of the Center for Plastic and Reconstructive Surgery
6. Cedars-Sinai study examines regional use of minimally invasive repair of aneurysms
7. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
8. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
9. University of Cincinnati neurotrauma team awarded $2.1M to test lab on a tube
10. National Medal of Science awarded to Stephen Benkovic of Penn State University
11. Additional $38M awarded to expand orthopedic trauma care research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD ... dose required and providing a CBD form that can be easily incorporated into liquid ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical ... the company with their  2017 New Product Innovation Award ... on extensive primary and secondary medical device market research by ... through its first-to-market OTC, drug-free pain relief product, the AVACEN ... approach to treating fibromyalgia widespread pain. ...
(Date:10/12/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today announced that it will release third-quarter 2017 ... 26, 2017, and will follow with a conference call ... a.m. Eastern Time. To participate on the call, please ... is 94093362. A ...
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
Breaking Medicine Technology: