Navigation Links
Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
Date:3/18/2010

LOS ANGELES Physician scientists from the Cedars-Sinai Heart Institute presented new findings on the effectiveness of routine aspirin therapy for preventing heart disease, a drug therapy for atrial fibrillation and the role left ventricular assist devices (LVADs) may play in weight reduction for obese patients with chronic end-stage heart failure who are considered for heart transplantation. These presentations were made at the American College of Cardiology's Scientific Session in Atlanta. Brief highlights from these studies are included below.

In addition to these presentations, Cedars-Sinai Heart Institute researchers will present findings on gender differences, minimally-invasive surgery, treatments for coronary artery disease and more. For a full listing of Cedars-Sinai presenters, please email sally.stewart@cshs.org.

Does Contemporary Trial Evidence Support the Routine Use of Aspirin in Primary Prevention of Heart Disease?

Although current guidelines generally recommend routine use of aspirin for primary prevention of heart disease in men and stroke in women, a meta-analysis of nine trials (104,331 patients) that had evaluated the efficacy of aspirin use in primary prevention of cardiovascular events suggests that aspirin therapy does not result in significant reduction in serious vascular events in either gender. The study indicated that aspirin therapy resulted in a minimal reduction in cardiovascular events, but it also resulted in a modest increase in bleeding risk.

"The results of this study challenge current guidelines regarding aspirin use for cardiovascular disease prevention," said Sanjay Kaul, M.D., director of the Vascular Physiology and Thrombosis Research Laboratory at the Burns and Allen Research Institute at Cedars-Sinai.

Dronedarone: New Atrial Fibrillation Drug Not Recommended as a "First Choice"

Recently approved as a therapy for patients with atrial fibrillation/flutter, Dronedarone was specifically designed to overcome the side effects of its parent compound, amiodarone, while effectively reducing arrhythmias. However, say the authors, there are uncertainties with respect to the drug's efficacy and safety. In an analysis of several clinical trials that have evaluated the impact of dronedarone on various cardiovascular end points and yielded mixed results, Cedars-Sinai cardiologists concluded that the available data support the use of dronedarone in select patient populations as a second- or third-line agent, but not as a therapy of first-choice in most patients with atrial fibrillation.

"In general, based on available evidence, it is difficult to support an approach to rhythm control in most patients with atrial fibrillation without first trying a rate-control strategy. More studies with longer follow-up are needed," says senior author Sanjay Kaul, M.D., director of the Vascular Physiology and Thrombosis Research Laboratory at the Burns and Allen Research Institute at Cedars-Sinai.

Implantation of a Ventricular Assist Device may aid in Weight Loss for Obese Patients Awaiting a Heart Transplant

For patients who are awaiting a heart transplant, Left Ventricular Assist Devices (LVAD) can literally mean the difference between life and death helping the patient's own weakened heart to continue pumping until a suitable donor organ becomes available. In this study, Heart Institute physicians and surgeons note that in addition to assisting the patient's own heart, LVADs can aid obese heart transplant patients in weight reduction. Weight loss in such patients is important because just as obesity is a risk factor for heart failure, it also is associated with poor outcomes after a heart transplant. It is therefore considered a relative contra-indication for transplant.

In this analysis of 19 patients who were awaiting a transplant, obese advanced heart failure patients lost more weight and reduced their body mass index (BMI) significantly after being implanted with an LVAD. Obese patients who received the device lost about 12 percent of their body weight, nearly double the amount of weight lost by patients who were not obese.

According to researchers, the weight loss in patients implanted with the LVAD likely resulted from a combination of factors: the device possibly caused more calories to be consumed while simultaneously also resulting in decreased caloric intake.

While the obese patients were previously very sedentary, the LVAD provided more cardiac capacity, thereby enabling these patients to become more active, improve their overall conditioning, and expend more calories. In addition, the total weight, shape and physical location of the LVAD in the abdomen likely played a role in reducing caloric intake.

"Achieving adequate weight loss appears difficult among obese heart failure patients who are unable to exercise due to de-conditioning and reduced cardiac capacity," said Ernst Schwarz, M.D., Ph.D., director of Multidisciplinary Heart Failure Research at the Cedars-Sinai Heart Institute. "LVADs could prove to be helpful in improving obese patients' outcomes."


'/>"/>

Contact: Sally Stewart
Sally.stewart@cshs.org
310-248-6566
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Research team led by Cedars-Sinai identifies genes linked to ulcerative colitis
2. 2009 Cedars-Sinai Board of Governors Gala Sponsored by Lexus Raises Over $2.6 Million
3. Justin Timberlake, Sam Nazarian, Younes Nazarian, David Nazarian, Larry and Sandy Post to Be Honored at 2009 Cedars-Sinai Board of Governors Gala Sponsored By Lexus
4. Outsmarting Brain Tumors: Cedars-Sinai Researchers, Neurosurgeons and Other Experts Present Free Conference for Adult Brain Tumor Patients and Caregivers
5. The Pediatric IBD Center at Cedars-Sinai Medical Center Presents Rock-n-Reel 2009 Honoring Alexandra Milchan-Lambert & Scott Lambert
6. ACC presents lifetime achievement award to Cedars-Sinai Heart Institutes James Forrester, M.D.
7. Cedars-Sinai Board of Governors to Honor Ryan Seacrest & John Bendheim at Annual Road To A Cure Gala
8. Barbra Streisand endows program at Cedars-Sinai womens heart center
9. Cedars-Sinai Medical Center opens patient trial of virus that attacks brain cancer cells
10. Hearts and Minds Promotes Wellness; African Americans Living with Mental Illness Have Higher Risk for Other Illnesses.
11. Minnesota State High School League and Take Heart Minnesota Team Up to Save More Lives From Sudden Cardiac Arrest (SCA)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
Breaking Medicine Technology: