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Cavities in Children Reduced Over 60 Percent by New Experimental Chewable Mints
Date:4/8/2008

ogression of cavities in 10 and 11 year-old children in Venezuela. The study participants took four mints daily, two in the morning after brushing their teeth and before eating breakfast and two in the evening after brushing their teeth, before going to bed. There were 200 children enrolled in the study and 195 who finished the one-year study with complete data. Ninety-six children were in the study group and received the BasicMints with CaviStat and 99 children were in the placebo group and received the sugarless mints without CaviStat.

The BasicMints study was funded by Ortek Therapeutics, Inc.

About BasicMints and CaviStat

BasicMints is a new experimental drug in pre-clinical testing designed to prevent the formation of tooth decay. This soft, chewable, sugarless, mint flavored tablet contains CaviStat, Ortek's innovative, fluoride-free, cavity fighting complex. BasicMints are designed to be dissolved and chewed into the biting and approximating surfaces of the back teeth. These vulnerable surfaces account for approximately 90 percent of cavities in children.

CaviStat is a new innovative, fluoride-free, cavity fighting complex that is designed to mimic and integrate the powerful alkali producing, acid neutralizing and remineralizing benefits of saliva. CaviStat was designed to counter the formation of dental cavities by simultaneously inhibiting the two fundamental processes known for more than a hundred years to be responsible for cavity development, namely, acid generation by bacterial fermentation of appropriate carbohydrate substrates and solubilization of tooth mineral by the acid generated. CaviStat contains the amino acid arginine, which when metabolized by certain plaque bacteria, results in elevation of dental plaque pH by alkali generation. It also contains bicarbonate, an important buffer in saliva; and calcium carbonate, a poorly soluble calcium salt. The latter provides a source of calcium to prevent tooth solubilization,
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SOURCE Ortek Therapeutics, Inc.
Copyright©2008 PR Newswire.
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