Navigation Links
Causes of serious pain syndrome closer to discovery

Researchers at the University of Liverpool have taken a major step forward in understanding the causes of a disorder which causes chronic pain in sufferers.

Complex Regional Pain Syndrome (CRPS) is a serious condition affecting a limb after an often small accident or operation. It can cause severe pain lasting many years, as well as limb swelling, hair and nail growth changes, and muscle atrophy, but until now there has been no clear evidence of the cause.

Now the research team from the University's Institute of Translational Medicine alongside colleagues at the University of Pecs, Hungary have successfully transferred antibodies from the serum of patients with CRPS to mice, causing many of the same symptoms to be replicated.

Dr Andreas Goebel, who works in the University of Liverpool and the specialist neurosciences NHS Walton Centre, led the study. He said: "CRPS is a serious condition which isn't fully understood. The findings of this study hint at a cause for it - harmful serum-autoantibodies - and raise the possibility of finding a treatment."

In mice injected with the antibodies from CRPS sufferers, there was significantly more swelling of the affected limbs compared to mice injected with antibodies from healthy volunteers. Similar to what is seen in patient's limbs, the paws of CRPS-antibody injected mice became more painful to pressure, and the paw tissues contained a higher concentration of the nerve-mediator Substance P.

Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.

Dr Goebel said: "It's quite possible that CRPS is caused by a fault in the immune system. This study seems to pinpoint the cause as autoantibodies, and by examining this area further we can look to develop a cure."


Contact: Jamie Brown
University of Liverpool

Page: 1

Related medicine news :

1. Research proves shock wave from explosives causes significant eye damage
2. Healthy component of red wine, resveratrol, causes pancreatic abnormalities in fetuses
3. Water pipe smoking causes significant exposure to nicotine and cancer-causing agents
4. TB lung infection causes changes in the diversity of gut bacteria in mice
5. Long-term antibiotic treatment for Q fever causes weight gain
6. Rural versus urban causes of childhood concussion
7. Major third-hand smoke compound causes DNA damage -- and potentially cancer
8. Mandatory arrest in domestic violence call-outs causes early death in victims
9. HIV drug used to reverse effects of virus that causes cervical cancer
10. Winter Dry Eye Season Causes Blurred Vision Warns Dry Eye Researcher
11. Lung Cancer Awareness Month: Dr. Sanjay Jain Looks to Repair the Damage that Smoking Causes
Post Your Comments:
(Date:10/13/2015)... ... 13, 2015 , ... PhyMed Healthcare Group , a ... partnership with WPC Healthcare , a provider of predictive analytics solutions for ... into an aggregated data repository necessary to perform reporting and analytics on selected ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... solutions, announced today their sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG ... Summit, GPUG Summit and NAVUG Summit are independent user conferences designed and led ...
(Date:10/13/2015)... Radnor, Pennsylvania (PRWEB) , ... October 13, 2015 ... ... and people through a unique private messaging application, announced today a significant contract ... for another five years. Independence plans to build on the growing success of ...
(Date:10/13/2015)... ... October 13, 2015 , ... A child without a healthy ... SmileCareClub , the leading remote invisible aligner system, has joined with Global Dental ... without it. For each aligner treatment plan purchased, SmileCareClub will donate one clinic visit ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... a first-of-its kind product that targets the unique health needs of new ... the American Pregnancy Association ( ), utilizes Nordic Naturals’ exclusive, new, ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)...  A minimally-invasive treatment just became available to men ... more than 10 years of clinical trials, the Food ... of High Intensity Focused Ultrasound (HIFU), a procedure that ... tissue and minimizing chances for erectile and urinary dysfunction ... a pioneering Miami urologist who ...
(Date:10/13/2015)... ALEXANDRIA, Va. , Oct. 13, 2015 /PRNewswire-USNewswire/ ... Pharmacists Association,s (NCPA) Digest , sponsored by ... to prescription medication and more diversified pharmacy revenue ... independent community pharmacies. NCPA Digest ... to patients and particularly those in underserved inner ...
(Date:10/13/2015)... , Oct. 13, 2015  Human Longevity, Inc. ... practice of medicine, announced today the launch of the ... project that has the potential to transform healthcare. The ... Diego, CA , at HLI,s headquarters facility. More ... in other US and International cities. ...
Breaking Medicine Technology: