Navigation Links
Causes of serious pain syndrome closer to discovery
Date:7/2/2014

Researchers at the University of Liverpool have taken a major step forward in understanding the causes of a disorder which causes chronic pain in sufferers.

Complex Regional Pain Syndrome (CRPS) is a serious condition affecting a limb after an often small accident or operation. It can cause severe pain lasting many years, as well as limb swelling, hair and nail growth changes, and muscle atrophy, but until now there has been no clear evidence of the cause.

Now the research team from the University's Institute of Translational Medicine alongside colleagues at the University of Pecs, Hungary have successfully transferred antibodies from the serum of patients with CRPS to mice, causing many of the same symptoms to be replicated.

Dr Andreas Goebel, who works in the University of Liverpool and the specialist neurosciences NHS Walton Centre, led the study. He said: "CRPS is a serious condition which isn't fully understood. The findings of this study hint at a cause for it - harmful serum-autoantibodies - and raise the possibility of finding a treatment."

In mice injected with the antibodies from CRPS sufferers, there was significantly more swelling of the affected limbs compared to mice injected with antibodies from healthy volunteers. Similar to what is seen in patient's limbs, the paws of CRPS-antibody injected mice became more painful to pressure, and the paw tissues contained a higher concentration of the nerve-mediator Substance P.

Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.

Dr Goebel said: "It's quite possible that CRPS is caused by a fault in the immune system. This study seems to pinpoint the cause as autoantibodies, and by examining this area further we can look to develop a cure."


'/>"/>

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Page: 1

Related medicine news :

1. Research proves shock wave from explosives causes significant eye damage
2. Healthy component of red wine, resveratrol, causes pancreatic abnormalities in fetuses
3. Water pipe smoking causes significant exposure to nicotine and cancer-causing agents
4. TB lung infection causes changes in the diversity of gut bacteria in mice
5. Long-term antibiotic treatment for Q fever causes weight gain
6. Rural versus urban causes of childhood concussion
7. Major third-hand smoke compound causes DNA damage -- and potentially cancer
8. Mandatory arrest in domestic violence call-outs causes early death in victims
9. HIV drug used to reverse effects of virus that causes cervical cancer
10. Winter Dry Eye Season Causes Blurred Vision Warns Dry Eye Researcher
11. Lung Cancer Awareness Month: Dr. Sanjay Jain Looks to Repair the Damage that Smoking Causes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... Have you ever wondered what “Karma” really means? Does ... the word “Karma.” , Vedic tradition, which gave birth to Hinduism, is one of ... the central concepts of this tradition. According to the wisdom of this heritage, Karma is ...
(Date:8/1/2015)... ... 2015 , ... Calvary Hospital today announced that it is embarking on a ... is to bring this Torah – dating from 1880 – back to kosher status, ... , Scroll No. 515, from the town of Taus-Domazlice, is on permanent loan ...
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders ... with the HOPE Movement of EvolvHealth. In what has been a long-term relationship between ... join their missions of purpose together to change the course of the network marketing ...
(Date:8/1/2015)... ... August 01, 2015 , ... On Tuesday, July 28th, Symantec ... are thought to have been behind the attack on Anthem Inc. which resulted in ... day exploits, watering hole attacks and spear phishing campaigns. , For Joe ...
(Date:8/1/2015)... ... 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe Organic Hair ... first small business donation to kick off the campaign for healing and Well-Being. , ... includes a complete line of raw, organic hair care products, as well as her ...
Breaking Medicine News(10 mins):Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:March4thforWellBeing Foundation Kickoff 2
... Telephone Contact in TreatmentCOLUMBIA, S.C., April 6 ... awarded Silver Honors for Health Plans and Health Networks ... . The honor was announced at the ... and Protection Awards Gala on April 1-2 ...
... achieves record success rates with a breakthrough hypnosis technique to quit ... ... CA (PRWEB) August 15, 2006 -- Franc Tausch, PhD, CCHT, of ... smoking for life by attending one personalized and individual hypnotherapy ...
... Calls on Americans to be Prepared to Offer Contributions, Goods, ... Left HomelessNEW YORK, April 6 The catastrophic earthquake in ... people dead and tens of thousands homeless is a subject ... Citizens Foundation in New York City. "Like all Americans, ...
... could delay orgasm six times longer than before , , ... men with premature ejaculation to delay their orgasm six times ... European men. , The men, with clinically diagnosed premature ejaculation, ... active ingredients (100 men) or the PSD502 spray, which contains ...
... D. Anderson Cancer Center have discovered a gene that protects ... in about half of all breast cancers. , The gene ... in several other types of cancer, the team reports in ... for diminished PTEN protein levels in breast cancer absent a ...
... first four in nation to receive accreditationGREEN BAY, ... Medical Center is one of the first four ... the National Accreditation Program for Breast Centers (NAPBC), ... the first breast program in Wisconsin to earn ...
Cached Medicine News:Health News:Companion Benefit Alternatives Awarded Silver Honors for Best Practices in Health Plans and Health Networks by URAC 2Health News:Companion Benefit Alternatives Awarded Silver Honors for Best Practices in Health Plans and Health Networks by URAC 3Health News:Hypnotherapy Breakthrough: Renowned Smoking Cessation Specialist Helps To Stop Smoking In One Session 2Health News:Topical Spray Helped Men With Premature Ejaculation 2Health News:Gene helps protect tumor suppressor in breast cancer 2Health News:Aurora BayCare is Wisconsin's First Nationally Accredited Breast Program 2
(Date:7/31/2015)... According to a new market research report " ... Oxide, Filtration, E-beam, Gamma), Services (Onsite & Offsite), Consumables (Indicators, ... to 2020", published by MarketsandMarkets, The Sterilization Equipment Market is ... a CAGR of 7.6%.from 2015 to 2020. ... ables and 37 F igures ...
(Date:7/31/2015)... PORTLAND, Ore., July 31, 2015  Semler Scientific, Inc. ... and testing services to healthcare insurers and physician groups, ... June 30, 2015. "In the second ... over year revenue growth of 54%, quarter over quarter ... of the installed base of FloChec® units of 18%," ...
(Date:7/31/2015)... Magnaquest, a leading Subscription ... cloud computing operators has signed a Proof of ... Internet of Things (IoT) related initiative. The PoC ... model.      (Logo: http://photos.prnewswire.com/prnh/20140807/700645 ) ... business innovations to make healthcare services more accessible ...
Breaking Medicine Technology:Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2
... CHADDS FORD, Pa., July 10 ... Pharmaceuticals (Nasdaq: ENDP ) jointly announced today that ... and market Urocidin(TM) in the U.S. with an option for ... Mycobacterial Cell Wall-DNA Complex (MCC) developed by Bioniche for the ...
... , ALEXANDRIA, Va., July 9 The world-wide explosion of ... of obesity is widely recognized. Could it really be an ... over the increasing prevalence of overweight conditions in our society, ... as a potential direct contributor to obesity. , ...
Cached Medicine Technology:Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 2Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 3Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 4Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 5Bioniche Life Sciences Inc. and Endo Pharmaceuticals Sign Licensing Agreement for Urocidin(TM) 6Is Obesity an Oral Bacterial Disease? 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: