Navigation Links
Causes of serious pain syndrome closer to discovery
Date:7/2/2014

Researchers at the University of Liverpool have taken a major step forward in understanding the causes of a disorder which causes chronic pain in sufferers.

Complex Regional Pain Syndrome (CRPS) is a serious condition affecting a limb after an often small accident or operation. It can cause severe pain lasting many years, as well as limb swelling, hair and nail growth changes, and muscle atrophy, but until now there has been no clear evidence of the cause.

Now the research team from the University's Institute of Translational Medicine alongside colleagues at the University of Pecs, Hungary have successfully transferred antibodies from the serum of patients with CRPS to mice, causing many of the same symptoms to be replicated.

Dr Andreas Goebel, who works in the University of Liverpool and the specialist neurosciences NHS Walton Centre, led the study. He said: "CRPS is a serious condition which isn't fully understood. The findings of this study hint at a cause for it - harmful serum-autoantibodies - and raise the possibility of finding a treatment."

In mice injected with the antibodies from CRPS sufferers, there was significantly more swelling of the affected limbs compared to mice injected with antibodies from healthy volunteers. Similar to what is seen in patient's limbs, the paws of CRPS-antibody injected mice became more painful to pressure, and the paw tissues contained a higher concentration of the nerve-mediator Substance P.

Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.

Dr Goebel said: "It's quite possible that CRPS is caused by a fault in the immune system. This study seems to pinpoint the cause as autoantibodies, and by examining this area further we can look to develop a cure."


'/>"/>

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Page: 1

Related medicine news :

1. Research proves shock wave from explosives causes significant eye damage
2. Healthy component of red wine, resveratrol, causes pancreatic abnormalities in fetuses
3. Water pipe smoking causes significant exposure to nicotine and cancer-causing agents
4. TB lung infection causes changes in the diversity of gut bacteria in mice
5. Long-term antibiotic treatment for Q fever causes weight gain
6. Rural versus urban causes of childhood concussion
7. Major third-hand smoke compound causes DNA damage -- and potentially cancer
8. Mandatory arrest in domestic violence call-outs causes early death in victims
9. HIV drug used to reverse effects of virus that causes cervical cancer
10. Winter Dry Eye Season Causes Blurred Vision Warns Dry Eye Researcher
11. Lung Cancer Awareness Month: Dr. Sanjay Jain Looks to Repair the Damage that Smoking Causes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 2014 This is a professional and ... Sterilizers industry with a focus on the Chinese market. ... of the Sterilizers manufacturers and is a valuable source ... in the industry. This report provides a basic overview ... technology. In this part, the report presents the company ...
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... the 2010 DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) ... LLP reports. According to an Order issued in the ... 20th, the Court will convene an open conference on ... Building and United States Courthouse in West Palm Beach, ...
(Date:12/25/2014)... The short film “Color of Honor” by young ... a true 9/11 hero, Welles Remy Crowther. It has been ... hours of Nuremberg International Short Film Festival and the 8th ... screenwriter and director Luciana Lagana plays the mother of ... husband, Gregory Graham - Graham plays a heroic ...
(Date:12/25/2014)... Miami, FL (PRWEB) December 25, 2014 When ... often find themselves in a frenzy to get rid of ... classroom. But families in Coral Gables now have the solution ... its second salon clinic location, Lice Troopers provides full spectrum ... in the Coral Gable area, including Sunset, Key Biscayne, Brickell, ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- Overeating is common ... you eat in moderation, an expert says. "Don,t arrive ... up calories if you know you,ll be attending a party, ... Jill Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount ... better to eat healthy during the day and even to ...
Breaking Medicine News(10 mins):Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Center dedicated the Paul Francis Baier Comprehensive Media Room on May 1, ... ... dedicated the Paul Francis Baier Comprehensive Media Room on May 1, ... Bret and Amy Baier and Amy,s parents Paul and Barbara Hills in ...
... Mich., May 5 Baptist Health ... Reuters to be a key component of its ... Health will use CareDiscovery Advance, a clinical performance ... and resource utilization. Built on the strength of ...
... help boost payment integrity and strengthen healthcare information networkNASHVILLE, ... a leader in revenue and payment cycle solutions, announced ... all of the assets of The Sentinel Group from ... Holding Company (Trustmark Companies). The Sentinel Group is a ...
... Pa., May 5 Nearly 100 APPRISE volunteers ... and related issues were honored for their efforts ... volunteers provide services through the state,s 52 Area ... to our older citizens who need help in ...
... , , WHAT: The community is invited ... of Momentum in Science, part of a four-part documentary, ... PROJECT on, ... distinguished panel of local, internationally renowned, ...
... immune to peer pressure. Scientists at the Stanford University School ... coaxed to behave like muscle cells and muscle cells ... out with: the relative levels of the ingredients inside the ... ease with which they make the switch, provide a glimpse ...
Cached Medicine News:Health News:Baier Media Room Advances Critical Care At Children's National Medical Center 2Health News:Baier Media Room Advances Critical Care At Children's National Medical Center 3Health News:Baptist Health South Florida Selects Clinical Performance Benchmarking Solution From Thomson Reuters 2Health News:Emdeon Announces Agreement to Acquire The Sentinel Group, a Leader in Healthcare Fraud and Abuse Management Services 2Health News:Emdeon Announces Agreement to Acquire The Sentinel Group, a Leader in Healthcare Fraud and Abuse Management Services 3Health News:Emdeon Announces Agreement to Acquire The Sentinel Group, a Leader in Healthcare Fraud and Abuse Management Services 4Health News:HBO, the Arizona Alzheimer's Consortium and the Alzheimer's Association, Desert Southwest Chapter Present a Free Advance Screening of THE ALZHEIMER'S PROJECT: Momentum In Science 2Health News:Extreme makeover: Stanford scientists explore new way to change cell's identity 2
(Date:12/22/2014)... Pa. and STOCKHOLM , ... (publ) (Sobi) and partner Auxilium Pharmaceuticals, Inc. today announced ... (CHMP) of the European Medicines Agency (EMA) has adopted ... clostridium histolyticum) for the treatment of adult men with ... of at least 30 degrees at the start of ...
(Date:12/22/2014)... 2014  Mark Farrah Associates (MFA), www.markfarrah.com ... of the 2015 marketplace exchange projections and insights ... According to a recent ASPE (Office of ... of Health and Human Services) report, an estimated ... plans through the Marketplace as of October 2014 ...
(Date:12/22/2014)...  Pfenex Inc. (NYSE MKT: PFNX) today announced the ... filed and is now open and that this program ... Health and Human Services (HHS), through the Biomedical Advanced ... extremely pleased to have the IND now active for ... milestone in our company,s partnership with BARDA as we ...
Breaking Medicine Technology:Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6Insights into the Marketplace and Individual Market Growth 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 3
... -   Retrospective sub-analyses from ADVANCE, ... European Association for the Study of the Liver (EASL) 2012 ... new data for INCIVO (telaprevir) from Phase 3 retrospective sub-analyses ... the Study of the Liver (EASL) in Barcelona.  The data ...
... Avion Pharmaceuticals, LLC, a specialty pharmaceutical company ... appointment of Michael Sullivan as Vice President, ... for all sales and marketing efforts for ... FAMILY™ of prenatal vitamins, newly reformulated with ...
Cached Medicine Technology:INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV 2INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV 3INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV 4INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV 5INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV 6INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV 7
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: