Navigation Links
Cause of effectiveness discovered for a cirrhosis treatment useful in 40 percent of patients
Date:2/27/2008

This release is available in Spanish.

Scientists of the Center for Applied Medical Research (CIMA) of the University of Navarra have discovered the molecular mechanism responsible for the effectiveness of an existing treatment for primary biliary cirrhosis, which combines two substances in order to produce an effect that does not result from either substance separately. The discovery involved the role played by the AE2 protein when the patient is treated with a combination of ursodeoxycholic acid (UDCA) together with glucocorticoids. The research results were recently published in The Journal of Clinical Investigation.

The origin of primary biliary cirrhosis (PBC)-which mostly affects middle-aged women-is still not understood. This pathology is associated with autoimmune phenomena, damage to the biliary vessels of the liver, and a reduction in the production of bile.

In Spain more than 1,000 cases are diagnosed each year, and the total number of patients worldwide is greater than 15,000. Dr. Juan Francisco Medina, Director of the Laboratory of Molecular Genetics of the CIMA, explains that in the present day the diagnosis of this disease, which is generally detected early, permits treatment with UDCA, which is effective in over half of the patients. However, nearly 40% of PBC patients do not respond satisfactorily to monotherapy with UDCA. Therefore, we looked for a combined treatment, and discovered that the combination of UDCA with glucocorticoids was a promising treatment for this group of patients. Those who suffer from this type of cirrhosis have a deficit of AE2, which is the protein for the secretion of bicarbonate in the bile.

The possibility of more cures with fewer transplants

The originality of this recently-published research article consists in relating, for the first time, the combined treatment with UDCA and glucocorticoids with a greater quantity of bicarbonate in the bile, and an improvement of the production of bile by the liver. Specifically, experiments in animal models and cell cultures demonstrate that only the combined treatment with UDCA and glucocorticoids increases the genetic expression of the human protein AE2 in the liver.

Based on available data, Dr. Medina considers that it is advisable to use combined treatment in those cases which present a poor response to monotherapy with UDCA. He proposes the use of a corticoid such as budesonida, which has fewer side effects than cortisone and prednisone. If, for fear of side effects, we allow the disease to progress, it is very probable that the only treatment will be a transplant. On the other hand, if this treatment option is confirmed as successful, it could reduce the number of transplants required in order to save the lives of patients.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related medicine news :

1. Drug for cluster headaches may cause heart problems
2. Study Points to Cause of Vioxx Heart Risk
3. Damp, Moldy Homes May Cause Depression
4. Constipations Many Causes and Cures
5. High Co-Pays Cause Seniors to Go Without Meds
6. 13 percent of women stop taking breast cancer drug because of side effects, U-M study finds
7. Vocal cord dysfunction may be caused by work
8. Study finds drug spending caps cause some seniors to quit taking key medicines
9. Medicare Spending Caps Cause Seniors to Stop Meds
10. Gene Mutations May Cause Rare Neonatal Diabetes
11. Patent Expiries of Proscar and Flomax/Harnal Will Cause a Significant Decline in Near-Term Sales of Benign Prostatic Hyperplasia Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... July 27, 2017 , ... SSCI, a division ... 600 patent challenges worldwide, representing a milestone achievement. , As an ... development, SSCI scientists have served as expert and fact witnesses to assist our ...
(Date:7/27/2017)... ... July 27, 2017 , ... Healthy eating isn’t always easy. Currently, more than 80 percent ... time, many Americans overeat refined grains and sugar. This trend may help explain why the ... the U.S. are obese. , As a culture, we seem to have food on the ...
(Date:7/27/2017)... ... 27, 2017 , ... Team Novo Nordisk, the world’s first all-diabetes professional cycling ... as a stagiaire for the remainder of the 2017 season. One of our best ... the Tour of Utah. , “Every season we are excited to move an athlete ...
(Date:7/26/2017)... ... July 26, 2017 , ... An inventor from Salisbury, N.C., ... haven’t yet seen an effective and dignified way to keep leeches in place during ... CUP." , This invention provides an effective way to keep a leech in place ...
(Date:7/26/2017)... ... , ... Six greater Bay Area roller derby leagues are partnering with Brown Paper Tickets and ... series of blood drives in California, beginning July 29. Make ‘Em Bleed roller derby blood ... enough to have helped to save up to 2700 lives. , “The Make ‘Em Bleed ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... Fla. , July 17, 2017  MedX Holdings, ... branded medical testing, strengthening and rehabilitation equipment, today announced ... Machine Program. MedX is considered the gold standard for ... leader in specialized medical strengthening equipment. ... a lease with the physician or practice who prescribe ...
(Date:7/13/2017)... RK Logistics Group, Inc. was awarded ... Fremont, CA headquarters facility where it ... San Jose for hi-tech, pharmaceutical and ... , with its Fremont Innovation District, is excited to strategically ... resource to the hundreds of biotech, pharma and biomed companies ...
(Date:7/11/2017)... , July 11, 2017  Bayer has awarded grants ... countries as part of its prestigious Bayer Hemophilia Awards Program ... of Philadelphia and Uniformed Services University ... are among the winners. Grant recipients were announced last night ... Hemostasis (ISTH) 2017 Congress, Berlin, Germany . ...
Breaking Medicine Technology: