Navigation Links
Cause and potential treatment found for cancer drug's kidney toxicity
Date:6/2/2011

AUGUSTA, Ga. Scientists may have a way to make the powerful cancer drug cisplatin less toxic to the kidneys and more effective against some cancers.

The chemotherapeutic agent used in combination with other drugs for a variety of cancers, results in kidney damage or failure in about 30 percent of users, although the mechanism has been unclear. The most physicians can do today to protect the kidneys is advise patients to drink more water.

The relatively simple, highly reactive compound tends to accumulate in the kidneys, said Dr. Navjotsingh Pabla, postdoctoral fellow at Georgia Health Sciences University and first author on the study in The Journal of Clinical Investigation. "The kidneys can take it up, but they have trouble removing it, so it just accumulates," he said.

The kidneys' endless workload of filtering some substances while resorbing others leaves them vulnerable to injury, one of the reasons the kidneys are the first organ to shut down when a patient is critically ill, said Dr. Zheng Dong, GHSU cell biologist, Career Research Scientist at the Charlie Norwood Veterans Affairs Medical Center in Augusta and the study's senior author. "Any stress to the cell can injure it," Dong said.

The scientists have shown in mice with tumors as well as human cancer cells in culture that cisplatin highly activates protein kinase C delta; protein kinases regulate other proteins by adding phosphates to them that can change their function. They've further shown that protein kinase C delta is a key mediator of cell death in kidneys and important to cancer cell survival.

The dichotomy appears useful because they've also shown that a drug, already in clinical trials for its potential in protecting brain cells following stroke, blocks the kidney destruction. In fact, protein kinase inhibitors in mice with tumors, enhanced breast and ovarian cancer treatment.

"Normal cells may not depend on this protein for survival and growth so if you remove it, there don't appear to be major negative consequences," Pabla said. The findings point toward using protein kinase C inhibitors as an adjunct therapy for patients experiencing kidney problems and potentially for all cancer patients treated with cisplatin if the enhanced efficacy finding continues to hold up, Dong said.

The scientists note that reducing the cisplatin dose decreases kidney toxicity but also decreases its efficacy and may leave the patient resistant to even higher doses of the drug. In the more than 30-year history with cisplatin, related drugs, such as carboplatin, have been developed to circumvent kidney damage, but those drugs tend to have more limited use, be less effective and/or have additional side effects. In more recent years, the focus has been on trying to protect the kidneys.

Next steps include working with chemists to see if an even more effective inhibitor can be developed.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. GW researchers show host Mta1 gene is required for optimal survival of schistosome parasites, a leading global cause of cancer
2. Cosmetics can cause serious adverse effects
3. Heart scientists discover protein that may be 1 cause of heart failure
4. Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
5. Newer Epilepsy Meds Less Likely to Cause Birth Defects: Study
6. A gene that fights cancer, but causes it too
7. Chiropractic Spinal Manipulation Wont Cause Chest Injuries, Study Contends
8. Mayo Clinic finds new genetic cause of neurodegeneration
9. Morning Heart Attacks Cause More Damage, Study Finds
10. Increased computer use by adolescents cause for concern
11. Wrestlers Quick Weight Loss May Cause Mental Confusion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cause and potential treatment found for cancer drug's kidney toxicity
(Date:8/18/2017)... VA (PRWEB) , ... August 18, 2017 , ... ... asset protection services and financial consultations to communities throughout the greater DC region, ... K9 with the goal of rescuing local animals and training them to be ...
(Date:8/18/2017)... ... August 18, 2017 , ... MLM ... that serves communities throughout southern Florida, is working to support the Take Stock ... children from low income families. , The Take Stock In Children Foundation (TSC) ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a ... Dallas/Fort Worth area, is spearheading a regional charity campaign organized to provide support to ... early June of this year, Christina and her children returned from out of town ...
(Date:8/18/2017)... ... ... and Overseer at The House of Yahweh in Abilene, Texas, has released a new publication ... mother of the Savior whom the world calls “Mother Mary”. Yisrayl says when compared to ... this historical woman. , “The world bows, kisses the feet of, cries out to ...
(Date:8/18/2017)... , ... August 18, 2017 , ... ... and call tracking and monitoring solutions, announced today the launch of a redesigned ... a modern navigation and aesthetic, fully responsive design, and an enhanced search directory ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... MEMPHIS, Tenn. , July 31, 2017 Three Tru-D ... in Yongsan, South Korea . Tru-D, short for "Total ... patient and operating rooms after an environmental services (ES) professional cleans the ... ... "Although ...
(Date:7/28/2017)... CHICAGO, July 28, 2017 Hill-Rom Holdings, Inc. ... fiscal third quarter ended June 30, 2017, and updated ... For the fiscal third quarter, ... to $0.68 per diluted share in the prior-year period. ... of $0.39 per diluted share primarily related to the ...
(Date:7/27/2017)... 27, 2017  Zimmer Biomet Holdings, Inc. (NYSE and ... June 30, 2017.  The Company reported second quarter net ... the prior year period, and an increase of 2.1% ... points of contribution from the LDR Holding Corporation acquisition, ... quarter of 2016, or 0.3% on a constant currency ...
Breaking Medicine Technology: