Navigation Links
Caught in the act: The dynamic dance of enzymes
Date:12/11/2007

d strategy that would capture not only the motion of a key protein, but its structures, as well. She had to make sure that the fleeting, more infrequent shapes of enzymes couldnt essentially wiggle out of the picture. These rarer enzyme states are critical to understand, as they are the ones most relevant to better drug design.

Ultimately, Kern harnessed five different elegant techniques, including X-ray crystallography, (NMR), single-molecule fluorescence resonance energy transfer (FRET), computer simulations of molecular dynamics, and paramagnetism, to reveal the full picture of how proteins fold in those infrequent, yet lightening-fast intermediate states between inactivity and activity. Each technique provided a piece of the puzzle.

The big goal here is to understand proteins well enough so that we can actually predict how they will behave, said Kern. These short-lived structures are most likely to have a higher affinity to drug molecules. Instead of relying on trial and error, scientists may be able to rationally design drugs to specifically bind to these intermediate conformations, according to Kern.

With the ability to capture an enzyme in real time as it is moving toward the active state, Kern and co-workers were able to detect picosecond (one millionth of one millionth of a second) changes, the fast smaller conformational motions, as well as the millisecond large-scale motions that are a result of the many fast motions.

This work will lead to understanding the physical nature of proteins not as a static picture but as an ensemble of structures, said Kern.


'/>"/>

Contact: Laura Gardner
gardner@brandeis.edu
781-736-4204
Brandeis University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Higher levels of pollutants found in fish caught near a coal-fired power plant
2. Extracts of catfish caught in polluted waters cause breast cancer cells to multiply
3. Dominium Benefits Experiencing Dynamic Growth
4. CardioDynamics Announces Third Quarter 2007 Conference Call and Webcast
5. International Consulting Firm Health Fitness Dynamics Hired to Oversee Springbrook Inns Planned New Spa
6. Dynamic Energy Systems Goes Online and On-Demand
7. Dynamic Files Articles of Merger; Notifies Nasdaq of Merger with GeoPharma
8. Optimal systemic and splanchnic hemodynamic state after living-donor liver transplantation
9. Cardinal Health Reaffirms Fiscal 2008 EPS Guidance, Updates Segment Profit Outlook
10. QMed, Inc. Comments on Estimated 3rd Quarter Results & Medical Expense Ratio; Sets 2008 Revenue Guidance for Medicare SNPs at $88-95 Million
11. Natural Alternatives International, Inc. Announces Late Filing of its Annual Report on Form 10-K, Revenue for Fiscal 2007 and Guidance on First Quarter of Fiscal 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... Parker & Sons, Inc. a market ... and other similar home contractor services announces a record ... its expert contracting services. The company is considered by ... serving Arizona for well over 40 years. Parker and ... in quality customer service to the residents and business ...
(Date:12/21/2014)... (PRWEB) December 21, 2014 Theme ... announced a new intro plugin for Final Cut Pro ... pictures, videos, logos, and more with absolute ease.” Said ... our users the tools needed to easily animate their ... Final Cut Pro X users to animate pictures, videos, ...
(Date:12/21/2014)... 21, 2014 The Oncology Institute of Hope ... Santa Ana and Whittier offices. The Hope for the Holidays ... of patients and their families during the holiday season. This ... approximately 70 children between both offices. This event continues to ... Target’s community service team, store managers and assistant managers came ...
(Date:12/20/2014)... BambooIndustry.com is a leading eco-friendly ... announced its bamboo flooring promotion for the coming ... certified suppliers, and offers the best bamboo products ... current promotion, all customers can enjoy a special ... they know BambooIndustry.com from press releases. , The ...
(Date:12/20/2014)... An improving macroeconomic landscape and a growing ... Massage Services industry over the five years to ... anticipated 1.0% annualized increase in per capita disposable income ... means to afford additional massages. “While the share of ... given year has declined from 2009 to 2012, this ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 2Health News:Parker & Sons Announces Record Number Of Favorable Reviews In 2014 With Regard To Its Expert Contracting Services 3Health News:Announcing a new plugin for Final Cut Pro X ProMotion from Pixel Film Studios. 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... Solutions, the leader in,driving peak Health Information Management ... by the Eastern Technology,Council of Pennsylvania as "Technology ... Gala held at the Kimmel Center. The ... sciences companies and entrepreneurs. More,than 1200 business ...
... Nov. 20 In a historic step toward a ... services and supports, the Leadership Council of Aging Organizations ... have agreed on a set of joint principles for ... Together, the two coalitions represent over 150 organizations representing ...
... infection that can cause meningitis, pneumonia in young children, ... officials said Thursday that a shortage of vaccine is ... most important causes of bacterial illness in young children. ... increase in cases, the stepped-up surveillance was prompted by ...
... Nov. 20 Want to lower your risk for type,2 diabetes ... activity,three times a day. Ten times three -- it,s really that ... recommend to help you,lower your blood pressure, manage your cholesterol and ... United States today, one in five people have diabetes, and heart,disease ...
... Sciences leaders have announced that they have executed ... & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), ... biomedical research and education to advance human health. ... future research and training efforts between the UC ...
... China Shenghuo,Pharmaceutical Holdings, Inc. (NYSE Alternext US: KUN) ... with its previous,announcements, it has filed with the ... amended Annual Report on Form 10-KSB/A for the ... on Form 10-Q/A for the,first quarter ended March ...
Cached Medicine News:Health News:Precyse Solutions Honored as 'Technology Company of the Year' 2Health News:National Senior and Disability Advocates Agree on Principles for Financing Long-Term Services and Supports 2Health News:National Senior and Disability Advocates Agree on Principles for Financing Long-Term Services and Supports 3Health News:National Senior and Disability Advocates Agree on Principles for Financing Long-Term Services and Supports 4Health News:CDC Monitors Shortage of Hib Vaccine 2Health News:CDC Monitors Shortage of Hib Vaccine 3Health News:10 Minutes at a Time: Simple Steps to Get Moving and Reduce Your Risk of Diabetes and Heart Disease 2Health News:UC San Diego announces collaboration with Johnson & Johnson Pharmaceutical Research & Development 2Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 2Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 3Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 4Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 5Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 6Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 7Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 8Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 9Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 10Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 11Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 12Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 13Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 14Health News:China Shenghuo Announces Restated Results For Full Year 2007 & First Quarter 2008, Reports Results For Second & Third Quarter 2008 15
(Date:12/17/2014)... Revenue and earnings above the previous ... development In the past 2013/14 fiscal year (ended ... to EUR 4.287 billion (last year: EUR 4.190 billion) despite ... EUR 360 million. "Overall, 2013/14 was a successful fiscal year ... President and CEO of Carl Zeiss AG. "Thanks to our ...
(Date:12/17/2014)... With advancements in neurological and functional ... seeing new growth, according to Kalorama Information. Though ... the majority of market volume, newer 3T systems ... are creating opportunities for more sophisticated applications. The medical ... a rate of 4%, with world market revenues ...
(Date:12/17/2014)... Dec. 17, 2014  ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... and Trademark Office (USPTO) has issued a key ... cell-based immunotherapeutic vaccine targeting six tumor antigens that ... US Patent No. 8,871,211, which issued October 28, ... administering a dendritic cell composition comprising peptide epitopes ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... AUGUSTINE, Fla., Aug. 10, 2011 Flagler Hospital ... selected the Sunrise Enterprise ™ suite of clinical ...  In addition to implementing Sunrise within the hospital, Flagler ... Record (EHR) and practice management solution for its ...
... Simbionix USA Corporation, the world,s leading provider of ... and the healthcare industry, is pleased to announce it ... its innovative PROcedure Rehearsal Studio ™ . ... in industry product, allowing clinicians to create patient specific 3D ...
Cached Medicine Technology:Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 2Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 3Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 4Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 5Flagler Hospital Selects the Sunrise Enterprise Acute Care Solution From Allscripts 6Patent Granted for Simbionix Procedure Rehearsal Studio™ 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: