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Catheter repair of mitral valve improves heart size, symptoms
Date:4/1/2008

result is a bow-tie-shaped opening that permits blood flow from the left atrium to the left ventricle during relaxation of the heart, and enables the valve flaps to close more effectively during contraction, rather than allowing leakage of blood backward into the left atrium.

The study by Dr. Hermiller and his colleagues focused on 23 patients treated at 15 medical centers either during the EVEREST I study or during the roll-in phase of the ongoing EVEREST II study, which is comparing MitraClip therapy to open-chest surgery. All of the patients in the new analysis had functional MR, which results not from a defect in the valve leaflets but from enlargement of the valve opening as a result of heart attack or heart failure. Of the quarter-million people newly diagnosed with mitral regurgitation in the United States each year, as many as two-thirds have the functional form, but it hasnt been clear whether the MitraClip would work as well in functional MR as in degenerative MR.

Before the procedure, all patients had moderately severe or severe mitral regurgitation, and 83 percent of patients had heart failure ranked as New York Heart Association (NYHA) functional class III or IV, which is characterized by lung congestion, shortness of breath, fatigue, swelling of the legs, and difficulty with light-to-moderate physical activity. After the procedure, mitral regurgitation was mild to modest in 19 of 22 patients (83 percent) treated with the MitraClip.

After one year, 12 patients had completed follow-up and had matched data from both baseline and follow-up. Ten of the 12 patients (83 percent) continued to have only mild to modest mitral regurgitation and nine of 12 (75 percent) continued to enjoy an improvement in symptoms and daily function of at least one NYHA class. In addition, heart size was significantly smaller. For example, the left ventricular internal diameter during relaxation, or diastole, fell from an average of 6.0 cm at baseline t
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Contact: Kathy Boyd David
pr@scai.org
717-422-1181
Weber Shandwick Worldwide
Source:Eurekalert

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