Navigation Links
Cathepsin B increases apoptosis in fulminant hepatic failure
Date:3/20/2009

The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the pathogenesis of fulminant hepatic failure. To ascertain its pathogenic role in hepatic failure, the research examined the protective effect of a cathepsin B inhibitor (CA-074Me) on fulminant hepatic failure in mice.

A research article to be published on March 14, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Yang in the Department of Infectious Diseases of the Second Clinical Hospital of Harbin Medical University investigated cathepsin B expression changes in the liver of fulminant hepatic failure. The article further indicated that LPS/D-Gal N-mediated cathepsin B expression initiates hepatocyte apoptosis in fulminant hepatic failure.

Cathepsin B, a lysosomal cysteine protease, is a candidate for an apoptotic mediator originating from acidic vesicles. CA-074me is a selective inhibitor of cathepsin B , and it is highly cell-permeant and can decrease the expression or activity of cathepsin B. The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. Inhibition of cathepsin B attenuates apoptosis and liver injury, supporting a link between cathepsin B and fulminant hepatic failure, and thus may provide new targets for further understanding of the pathogenesis of fulminant hepatic failure and new therapeutic targets.


'/>"/>

Contact: Jian-Xia Cheng
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. Seniors Seek to Reduce Healthcare Costs as Anthem Blue Cross Increases Premiums
2. Leader in Health Plan Cost Containment Cites Three Economy-Driven Reasons Why Self-Insured Health Plans Should Brace for Claim Increases and Fund Reserves Accordingly
3. Roche Increases Offer Price for Genentech Shares to US$ 93.00 per Share and Extends Offer
4. Depression increases risk for heart disease more than genetics or environment
5. Kidney Disease Increases the Risk of Stroke in Patients With the Most Common Type of Heart Arrhythmia, According to Kaiser Permanente Study
6. Kidney disease increases the risk of stroke in patients
7. Hallmark Cards Increases Investment In Cards For a Cure™ with Major Advertising and PR Campaign for Mother's Day 2009
8. Universal Health Services, Inc. Reports Significant Increases in 2008 Fourth Quarter and Full Year Earnings from Continuing Operations Per Diluted Share and Reports 2009 Guidance
9. Vinpower Digital Increases Blu-ray Disc Duplication Speed to 8X for Both Their Manual Tower and Autoloader Series Duplicators
10. Physical fitness improves spatial memory, increases size of brain structure
11. Miami Childrens Hospital Increases Efficiency With MediTracts Contract Management Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... , ... MedPro Waste Disposal, LLC (MedPro) is proud to announce that it ... back service for an all-inclusive rate. MedPro Disposal President, Dan Hansen, says, “We’re really ... of the clients in the country who are looking for an alternative to their ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... Dr. Rassouli, ... dental health and cognitive decline. According to the research, which was published in the ... degree of cognitive decline, and about 5.4 million Americans have Alzheimer’s disease. The study ...
(Date:5/2/2016)... N.Y. (PRWEB) , ... May 02, 2016 , ... According ... Prevention says one in four girls are sexually abused before the age of 18. ... Bishop lives to tell her story and others. , In her new book, ...
(Date:5/2/2016)... St. Louis, MO (PRWEB) , ... May 02, ... ... ROHO Inc., a division of Permobil, recently completed two groundbreaking studies that determined ... cushions and mattresses – are critical in the prevention of pressure injuries, which ...
(Date:5/2/2016)... ... May 02, 2016 , ... MedaCheck, a leading medication ... outcomes, has announced its partnership with GrandView Health Services. , With decades of ... counter and prescription drug pharmacy services to thousands of residents. Serving Indiana, Ohio, ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 2016  In the next ten years, the ... systems dependent on CRTs monitors to those reliant on ... Medical monitors and will automatically sync to existing ... foreseeable benefits to this technological advancement, it also ... to be replaced in order to be LCD ...
(Date:4/29/2016)... Glycotope GmbH, a clinical-stage immuno-oncology company built ... Dr. Alfredo Zurlo as Chief Medical Officer. ... years clinical experience and a proven track record in ... at Mologen AG where he was Chief Medical Officer ... held various positions at F Hoffmann La Roche and ...
(Date:4/28/2016)... 2016 Research and Markets has ... Products Market 2016-2020" report to their offering. ... The global plastic surgery products market is expected ... period 2016-2020. , ,The growing adoption of laser in ... of the market. Lasers are used to treat a ...
Breaking Medicine Technology: