Navigation Links
Catching Ovarian Cancer Early May Miss Aggressive Tumors

The finding casts the usefulness of screening into doubt, scientists say

TUESDAY, March 24 (HealthDay News) -- Early-stage ovarian cancers may be slower growing and less likely to spread than the more aggressive forms typically found in advanced stages of the disease, researchers report.

The finding calls into question the effectiveness of ovarian cancer screening, the study authors say.

"Our study showed that the ovarian cancers currently detected at an early stage have gene expression profiles that correlate with favorable outcomes, rather than being representative of the entire spectrum of disease aggressiveness. This highlights the potential challenges of developing a screening test for this disease, because earlier detection of aggressive cases is essential if screening is to reduce ovarian cancer deaths," lead investigator Dr. Andrew Berchuck, a gynecologic oncologist at Duke Comprehensive Cancer Center, in Durham, N.C., said in a Duke news release.

He and his colleagues analyzed gene expression patterns in 166 ovarian cancer tissue samples, including advanced ovarian cancers from patients who lived more than seven years and from patients who died within three years of diagnosis. The analysis revealed genes associated with longer survival.

"We found that certain patterns predicted long-term survival, and others predicted a poor prognosis in advanced stage cases. Cancers that were detected at an early stage almost always shared gene expression characteristics with advanced stage cases that were long-term survivors, suggesting a shared favorable biology," Berchuck said.

The study was published in the March 24 issue of the journal Clinical Cancer Research.

"While these results could be seen as discouraging, it must be remembered that this information is an important piece of the ovarian cancer puzzle, and data like these that increase our understanding of the disease hopefully will eventually lead to breakthroughs in prevention, early detection and treatment of this deadly disease," Berchuck said.

Currently, there is no approved ovarian cancer screening test for the general population, but the CA125 blood test and transvaginal ultrasound imaging are being evaluated in clinical trials.

More information

The American Cancer Society has more about ovarian cancer.

-- Robert Preidt

SOURCE: Duke Medicine, news release, March 24, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New survey: Flu Shot Still not Catching on, Especially at Retail Clinics
2. Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening
3. Morphotek(R), Inc. and Eisai Corporation of North America Announce FDA Special Protocol Assessment (SPA) for Phase III Trial Evaluating Farletuzumab in Relapsed Ovarian Cancer
4. Combo Screening Doesnt Spot Early Ovarian Cancer
5. Early Detection Remains Key in Updated NCCN Guidelines for Ovarian Cancer
6. Combo of Tests Might Spot Ovarian Cancer Early
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. Fertility Drugs Do Not Increase Ovarian Cancer Risk
9. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
10. Fujirebio Diagnostics and Abbott Agree To Develop New Ovarian Cancer Test for Abbotts Architect(R) Analyzers
11. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
Post Your Comments:
Related Image:
Catching Ovarian Cancer Early May Miss Aggressive Tumors
(Date:10/12/2015)... ... ... to an article published October 6th by the Herald Tribune, a recent study ... taken in 1988 has shown that it really is more difficult to lose weight these ... someone in 1971 would be on average 10 pounds heavier than their past counterpart. In ...
(Date:10/12/2015)... ... October 12, 2015 , ... ... 19, 2015, high school aged female athletes, particularly in the area of track ... motion and mechanical overuse injuries than male peers in the same age group. ...
(Date:10/12/2015)... ... October 12, 2015 , ... According to an article published September ... an efficient way to save money on the healthcare needs of patients across the ... patients, house call visits can often effectively eliminate the need to go in and ...
(Date:10/12/2015)... ... October 12, 2015 , ... According to an article published ... San Antonio, Texas recommended that any high-rises in the city limits that do not ... forward. The article explains that it wasn’t until 1982 that the city started requiring ...
(Date:10/12/2015)... , ... October 12, 2015 , ... The Horizon Foundation ... initiatives focused on improving public health and enhancing the quality of life in the ... to 11 New Jersey non-profit organizations. , The charitable arm of Horizon Blue ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... , Oct. 12, 2015 Zimmer Biomet ... third quarter 2015 sales and earnings conference call will ... 29, 2015, at 8 a.m. Eastern Time.  A news ... at 7:30 a.m. Eastern Time the morning of the ... archived for replay following the conference call. --> ...
(Date:10/12/2015)... PARK, Calif. , Oct. 12, 2015 ... R&D and Chief Scientific Officer of Asterias ... biotechnology company in the emerging field of ... Dealmakers webcast, sponsored in part by Asterias ... Dr. Lebkowski will discuss the progress to ...
(Date:10/12/2015)... , Oct. 12, 2015 This study focuses ... and company profiles. In the two past decades, the industry ... of the manufacturing capabilities and rising consumer consumptions in ... society and economy. China is ... products. Far outpacing other economies in the world, ...
Breaking Medicine Technology: