Navigation Links
Catching Ovarian Cancer Early May Miss Aggressive Tumors
Date:3/24/2009

The finding casts the usefulness of screening into doubt, scientists say

TUESDAY, March 24 (HealthDay News) -- Early-stage ovarian cancers may be slower growing and less likely to spread than the more aggressive forms typically found in advanced stages of the disease, researchers report.

The finding calls into question the effectiveness of ovarian cancer screening, the study authors say.

"Our study showed that the ovarian cancers currently detected at an early stage have gene expression profiles that correlate with favorable outcomes, rather than being representative of the entire spectrum of disease aggressiveness. This highlights the potential challenges of developing a screening test for this disease, because earlier detection of aggressive cases is essential if screening is to reduce ovarian cancer deaths," lead investigator Dr. Andrew Berchuck, a gynecologic oncologist at Duke Comprehensive Cancer Center, in Durham, N.C., said in a Duke news release.

He and his colleagues analyzed gene expression patterns in 166 ovarian cancer tissue samples, including advanced ovarian cancers from patients who lived more than seven years and from patients who died within three years of diagnosis. The analysis revealed genes associated with longer survival.

"We found that certain patterns predicted long-term survival, and others predicted a poor prognosis in advanced stage cases. Cancers that were detected at an early stage almost always shared gene expression characteristics with advanced stage cases that were long-term survivors, suggesting a shared favorable biology," Berchuck said.

The study was published in the March 24 issue of the journal Clinical Cancer Research.

"While these results could be seen as discouraging, it must be remembered that this information is an important piece of the ovarian cancer puzzle, and data like these that increase our understanding of the disease hopefully will eventually lead to breakthroughs in prevention, early detection and treatment of this deadly disease," Berchuck said.

Currently, there is no approved ovarian cancer screening test for the general population, but the CA125 blood test and transvaginal ultrasound imaging are being evaluated in clinical trials.

More information

The American Cancer Society has more about ovarian cancer.



-- Robert Preidt



SOURCE: Duke Medicine, news release, March 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New survey: Flu Shot Still not Catching on, Especially at Retail Clinics
2. Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening
3. Morphotek(R), Inc. and Eisai Corporation of North America Announce FDA Special Protocol Assessment (SPA) for Phase III Trial Evaluating Farletuzumab in Relapsed Ovarian Cancer
4. Combo Screening Doesnt Spot Early Ovarian Cancer
5. Early Detection Remains Key in Updated NCCN Guidelines for Ovarian Cancer
6. Combo of Tests Might Spot Ovarian Cancer Early
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. Fertility Drugs Do Not Increase Ovarian Cancer Risk
9. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
10. Fujirebio Diagnostics and Abbott Agree To Develop New Ovarian Cancer Test for Abbotts Architect(R) Analyzers
11. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Catching Ovarian Cancer Early May Miss Aggressive Tumors
(Date:10/13/2017)... , ... October 13, 2017 , ... ... serving communities in the greater Dallas, Miami, and Raleigh regions, is organizing an ... to overcome a rare and deadly chromosome abnormality. , After struggling since birth ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of Eating ... excellence for the field of eating disorders, announces the opening of early registration ... Orlando, Florida at the Omni Resort at ChampionsGate. , The annual ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, ... formed by Walgreens and pharmacy benefit manager Prime Therapeutics ... new brand, which included the unveiling of new signage ... , as well as at a few other company-owned ... new brand to patients, some of whom will begin ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
Breaking Medicine Technology: