Navigation Links
Catching Ovarian Cancer Early May Miss Aggressive Tumors
Date:3/24/2009

The finding casts the usefulness of screening into doubt, scientists say

TUESDAY, March 24 (HealthDay News) -- Early-stage ovarian cancers may be slower growing and less likely to spread than the more aggressive forms typically found in advanced stages of the disease, researchers report.

The finding calls into question the effectiveness of ovarian cancer screening, the study authors say.

"Our study showed that the ovarian cancers currently detected at an early stage have gene expression profiles that correlate with favorable outcomes, rather than being representative of the entire spectrum of disease aggressiveness. This highlights the potential challenges of developing a screening test for this disease, because earlier detection of aggressive cases is essential if screening is to reduce ovarian cancer deaths," lead investigator Dr. Andrew Berchuck, a gynecologic oncologist at Duke Comprehensive Cancer Center, in Durham, N.C., said in a Duke news release.

He and his colleagues analyzed gene expression patterns in 166 ovarian cancer tissue samples, including advanced ovarian cancers from patients who lived more than seven years and from patients who died within three years of diagnosis. The analysis revealed genes associated with longer survival.

"We found that certain patterns predicted long-term survival, and others predicted a poor prognosis in advanced stage cases. Cancers that were detected at an early stage almost always shared gene expression characteristics with advanced stage cases that were long-term survivors, suggesting a shared favorable biology," Berchuck said.

The study was published in the March 24 issue of the journal Clinical Cancer Research.

"While these results could be seen as discouraging, it must be remembered that this information is an important piece of the ovarian cancer puzzle, and data like these that increase our understanding of the disease hopefully will eventually lead to breakthroughs in prevention, early detection and treatment of this deadly disease," Berchuck said.

Currently, there is no approved ovarian cancer screening test for the general population, but the CA125 blood test and transvaginal ultrasound imaging are being evaluated in clinical trials.

More information

The American Cancer Society has more about ovarian cancer.



-- Robert Preidt



SOURCE: Duke Medicine, news release, March 24, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New survey: Flu Shot Still not Catching on, Especially at Retail Clinics
2. Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening
3. Morphotek(R), Inc. and Eisai Corporation of North America Announce FDA Special Protocol Assessment (SPA) for Phase III Trial Evaluating Farletuzumab in Relapsed Ovarian Cancer
4. Combo Screening Doesnt Spot Early Ovarian Cancer
5. Early Detection Remains Key in Updated NCCN Guidelines for Ovarian Cancer
6. Combo of Tests Might Spot Ovarian Cancer Early
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. Fertility Drugs Do Not Increase Ovarian Cancer Risk
9. Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
10. Fujirebio Diagnostics and Abbott Agree To Develop New Ovarian Cancer Test for Abbotts Architect(R) Analyzers
11. The 2009 Damon Runyon-Rachleff Innovation Award Granted for Pioneering Ideas for Early Detection of Ovarian and Lung Cancers, Bone Marrow Transplant Safety, and Discovery of New Genetic Markers for Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Catching Ovarian Cancer Early May Miss Aggressive Tumors
(Date:4/25/2017)... Richmond, BC (PRWEB) , ... April 25, 2017 , ... ... patients from Richmond, BC, who live with dental fear and require sedation to receive ... anxiety at ease during various procedures, from hygienic cleanings to oral surgery, at ...
(Date:4/25/2017)... , ... April 25, 2017 , ... ... they rely on contracted partners to help with process innovation in drug formulation ... drug formulation experience along with state-of-the-art analytical equipment in support of their development ...
(Date:4/25/2017)... MN (PRWEB) , ... April 25, 2017 , ... Buyers ... and recreational users to dispensaries and head shops –can’t help but be heartened by ... for the tell-tale cannabis odor aptly described as “skunk smell.” At last they ...
(Date:4/25/2017)... ... 25, 2017 , ... Emergency Physician and Distinguished Professor of Emergency Medicine Bentley ... in Writing, set to publish in summer 2017. , Dr. Bobrow, MD, FACEP, ... Arizona College of Medicine. He also serves as Medical Director for the Bureau of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Amendia, Inc., designer, developer, and ... partnership with and platinum sponsorship of Global Spine Outreach (“GSO”), a charitable organization ... of complex spine deformity cases, particularly in children. , GSO’s focus is to ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 2017 Eyevensys, a private biotechnology ... gene expression technology that enables the safe, local, sustained ... a wide range of ophthalmic diseases, announces it has ... Regulatory Agency (MHRA) to advance its technology into clinical ... The ...
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment ... projected period The Cardiology Devices segment is likely ... US$ 15 Mn in 2018 over 2017. By the end ... market valuation close to US$ 700 Mn, expanding at a ... segment dominated the Asia Pacific reprocessed ...
(Date:4/19/2017)... NEW YORK , April 19, 2017 /PRNewswire/ ... This report on the prostate cancer ... of the global market. Increasing prevalence of prostate ... as innovation in the development of new drugs ... hormone-refractory prostate cancer drug due to lesser side ...
Breaking Medicine Technology: