Navigation Links
Catch and release
Date:11/12/2012

BOSTON, MAA research team at Brigham and Women's Hospital has developed a novel device that may one day have broad therapeutic and diagnostic uses in the detection and capture of rare cell types, such as cancer cells, fetal cells, viruses and bacteria. The device is inspired by the long, elegant appendages of sea creatures, such as jellyfish and sea cucumbers.

The study will be published online on November 12, 2012 in Proceedings of the National Academy of Sciences.

The device, a microchip, is inspired by a jellyfish's long, sticky tentacles that are used to capture miniscule food flowing in the water. The researchers designed a chip that uses a three-dimensional DNA network made up of long DNA strands with repetitive sequences thatlike the jellyfish tentaclescan detect, bind and capture certain molecules.

The researchers, led by Jeffrey Karp, PhD, BWH Division of Biomedical Engineering, Department of Medicine at Brigham and Women's Hospital, senior study author, and Rohit Karnik, PhD, Massachusetts Institute of Technology, co-author, created the chip using a microfluidic surface and methods that allowed them to rapidly replicate long DNA strands with multiple targeting sites that can bind to cancer cells, but also custom tailor critical characteristics, such as DNA length and sequence which would allow them to target various cell types.

In this study, Karp and his team tested the chip using a DNA sequence that had a specific affinity to a cell-surface protein found abundantly in human cancer cells.

The researchers engineered the device to efficiently capture a higher quantity of cancer cells from whole blood patient samples at much higher flow rates compared to other methods that use shorter DNA strands or antibodies.

"The chip we have developed is highly sensitive. From just a tiny amount of blood, the chip can detect and capture the small population of cancer cells responsible for cancer relapse," said Weian Zhao, PhD, a postdoctoral fellow from the Karp lab who is now faculty at the University of California, Irvine, and first study author.

In addition to using the device for blood-based cancers, it may find application to isolate cells that break away from solid tumors and travel through the bloodstream.

"What most people don't realize is that it is the metastasis that kills, not the primary tumor," said Karp. "Our device has the potential to catch these cells in the act with its 'tentacles' before they may seed a new tumor in a distant organ."

Moreover, unlike other methods, the device was able to maintain a high purity of the captured cells that could easily be released and cultured in the laboratory.

"One of the greatest challenges in the treatment of cancer patients is to know which drug to prescribe," said Karp. "By isolating circulating tumor cells before and after the first round of chemotherapy is given, we can determine the biology behind why certain cells are resistant to chemotherapy. We can also use the isolated cells to screen drugs for personalized treatments that could boost effectiveness and hopefully prevent cancer relapse."


'/>"/>
Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert  

Related medicine news :

1. Heat, rainfall affect pathogenic mosquito abundance in catch basins
2. CSHL Press releases new book on the biology of drug addiction
3. Institute for Population Health Improvement releases buyers guide for health information exchange
4. Premier global health journal, The Lancet, releases series on universal health coverage
5. Evidence that new biomimetic controlled-release capsules may help in gum disease
6. PMIC Announces Release of New CDT 2013 Dental Procedure Coding System
7. Muscular Development Store Releases the Optimum Performance Workout for High Intensity Training
8. MTSS-mba Membership Benefits Administration Software for Private and Taft-Hartley Employee Benefit Funds Releases New Pension Modules
9. Candeo Partners with Catholic Church Organization to Release New Sexual Addiction Recovery Program
10. GMC Denali Road Bike Review Released Today By GMCDenaliRoadBike.net
11. Waterpik Water Flosser Reviews Released Today By WaterpikReviews.net
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Catch and release
(Date:12/7/2016)... ... December 07, 2016 , ... Baciocco Brothers Insurance Agency, a ... the Sacramento/Folsom region, is initiating a charity event to raise support and awareness ... Chance treatment center in Sacramento works to provide area teens and families with ...
(Date:12/7/2016)... ... ... A. Kevin Spann Insurance, a New York-based firm offering insurance and financial consultation ... drive to raise funds that will benefit the Marine Corps League. , The Marine ... Corpsmen. Working closely with the MCL, the A. Kevin Spann team plans to generate ...
(Date:12/7/2016)... ... 2016 , ... Facial plastic surgeon, Dr. John D. Rachel of Timeless ... proceeds to two local organizations: North Chicago Animal Control and Friends and Our House ... team of authorized and trained volunteers who support rescued animals held in the City ...
(Date:12/7/2016)... ... December 07, 2016 , ... The medical profession is well aware that heart ... major study analyzing heart attacks among 138,602 people recorded a 35% higher number of ... would all agree of course–no time of year is a good time for a ...
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen McLaughlin, LA.c., a certified ... Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years of experience with fertility ... patients realize their family building goals. Acupuncture helps fertility patients by ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... -- Alopexx Oncology, LLC announced data from a Phase I ... composed of interleukin-2 and a CD20-targeting monoclonal antibody. The ... as Rituxan and maintains the activities of both the ... tumor targeting, engagement of the immune system, and induction ... study (abstract #95954) were presented at the 58 th ...
(Date:12/6/2016)... Dec. 6, 2016 Diabetes & Obesity Drug ... and obesity disease cluster is currently dominated by therapeutics ... 2 diabetes mellitus (T2DM), and the majority of the ... products, is attributable to these indications. While products indicated ... presence, there are a large number of these products ...
(Date:12/6/2016)... The pen needles market is projected to reach USD ... 2016, growing at a CAGR of 11.2% during the ... years, the pen needles market has witnessed various technological ... for safety injections in the healthcare industry. These advancements ... with an aim to reduce pain, increase comfort, and ...
Breaking Medicine Technology: