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Catalyst mystery unlocked
Date:8/18/2008

each other, they would bind.

Warshel's model reproduced new experimental data showing that a natural enzyme and its engineered, structurally different counterpart both have the same catalytic power, despite being very different from each other.

The engineered enzyme, made by co-author Donald Hilvert of ETH in Zurich, Switzerland, displays less distinct folding than the natural enzyme. It also changes shape very rapidly.

Warshel's model shows that the engineered enzyme takes the shape of many keys, with all fitting electrostatically in the same lock. This should offer a new option for enzyme design.


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Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
Source:Eurekalert

Page: 1 2

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