Navigation Links
Catalyst mystery unlocked
Date:8/18/2008

Different keys are not supposed to fit the same lock, but in biological systems multiple versions of a catalyst all make a reaction go, according to a new study that explains the phenomenon.

Scheduled for online publication in PNAS Early Edition sometime after Aug. 18, the study challenges entrenched ideas about the workings of catalysts.

The study also suggests a method for designing new catalysts.

Catalysts are molecules that speed up chemical reactions without participating in them. Thousands of industrial and biological processes rely on catalysts. In the human body, enzymes catalyze almost every reaction.

"The Holy Grail of enzyme catalysis and the ultimate manifestation of understanding of this process is the ability to design enzymes," said senior author Arieh Warshel, professor of chemistry at USC College.

He listed drug production, environmental chemistry and bioremediation as areas that could be revolutionized by custom-designed enzymes.

In the PNAS study, Warshel described a computational model that both explains a key aspect of catalyst function and suggests a design strategy.

Since the early days of catalyst chemistry, scientists had championed the "lock and key" model, which held that a catalyst worked by exquisitely surrounding and matching the reacting system (the substrate).

Warshel's group has published several papers in support of an alternate theory based on electrical attraction. According to the group, a perfect physical fit between catalyst and substrate is not necessary.

"What really fits is the electrostatic interaction between the enzyme active site to the substrate charges at the so-called transition state, where the bonds are halfway to being broken," Warshel said.

If Warshel is correct, catalyst and substrate would be less like lock and key, and more like two magnets: As long the opposite poles could get close to each other, they would bind.

Warshel's model reproduced new experimental data showing that a natural enzyme and its engineered, structurally different counterpart both have the same catalytic power, despite being very different from each other.

The engineered enzyme, made by co-author Donald Hilvert of ETH in Zurich, Switzerland, displays less distinct folding than the natural enzyme. It also changes shape very rapidly.

Warshel's model shows that the engineered enzyme takes the shape of many keys, with all fitting electrostatically in the same lock. This should offer a new option for enzyme design.


'/>"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
Source:Eurekalert

Related medicine news :

1. CATalyst Council Forms to Address Feline Health Care
2. Congress Approves ePrescribing Initiative in Medicare Reform Bill: Critical Catalyst in Driving a New Generation of Prescribing
3. Catalyst Pharmaceutical Partners, Inc. Set to Join Russell Microcap(R) Index
4. Case in Point: Patient Control of Data Critical Catalyst for Online Health Care Revolution
5. Catalyst Pharmaceutical Partners, Inc. Names Director - Corporate Clinical Compliance
6. Cardiva Medical, Inc. to Present Highlights of the Boomerang Catalyst(TM) II System at the Investment in Innovation (In3) West Conference on February 29, 2008 in Las Vegas, NV
7. CATalyst Summit Declared a Success: Its All About the Cat!
8. Catalyst Pharmaceutical Partners Announces Positive Phase II Trial Results for Vigabatrin in the Treatment of Cocaine Addiction
9. Catalyst Pharmaceutical Partners Reports Third Quarter 2007 Financial Results
10. Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM)
11. Cardiva Medical, Inc. to Present at the UBS 2007 Global Life Science Conference With the Announcement of FDA 510(K) Clearance of its Newest Device: The Boomerang Catalyst II System(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on the ... announced that patient enrollment in its ongoing randomized ... has exceeded 50% of its 24-patient target. Capricor ... the third quarter of 2016, and to report ...
Breaking Medicine Technology: