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Catalyst Pharmaceutical Partners Announces Positive Phase II Trial Results for Vigabatrin in the Treatment of Cocaine Addiction
Date:12/7/2007

gnificantly increase abstinence compared to placebo. Subjects were randomly assigned to either a placebo or vigabatrin and were treated for a period of nine weeks. Of the 103 participants in the trial, 50 were treated with vigabatrin and 53 received placebo. Twice-weekly urine screening tests were obtained from each subject in order to objectively evaluate each subjects' cocaine use. All subjects were also offered one group counseling session per week.

The primary outcome measure of the trial was negative urine tests for cocaine for the last three weeks of the nine-week trial.

A total of 18 subjects fulfilled the criteria for the primary outcome measure. Of these, 14 (28%) were treated with vigabatrin versus four (7.6%) who were treated with placebo. A logistic regression utilizing years of cocaine use and average amount per day at baseline yielded statistically significant treatment differences. The p-value was 0.009.

There were no serious adverse events reported in this trial.

"These positive results demonstrate that there is hope for the millions of individuals who suffer from the life threatening consequences of this terrible illness," said Dr. Brodie. "It also demonstrates how a dedicated team of basic scientists and clinicians who persevere in a mission can produce important medical advances by taking an idea from the bench to the community."

Investor Conference Call

Catalyst will hold a conference call today to discuss the trial results. Investors wishing to participate may access the live call as follows:

Date: December 7, 2007

Time: 11:00 AM ET

Dial-in numbers: 888-802-2266 (U.S. only) or 913-312-1294

Live webcast: http://www.catalystpharma.com

A recording of the conference call will be available two hours after completion until Wednesday, December 12, 2007 at 11:59 PM ET at 888-203-1112 (U.S. only) or 719-457-0820. The
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SOURCE Catalyst Pharmaceutical Partners, Inc.
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