Navigation Links
Case Western Reserve awarded $1.57M for corneal infection research
Date:10/7/2009

Researchers at Case Western Reserve University School of Medicine have been awarded a $1.57 million renewal grant from the National Eye Institute (NEI) of the National Institutes of Health to continue their study of corneal infections, specifically, bacterial keratitis, associated with contact lens wear. The grant will extend the work initiated last year with the receipt of a $2.4 million, five-year grant from the NEI.

The funding will support for four years the work of Eric Pearlman, Ph.D., professor and research director in the Department of Ophthalmology and Visual Sciences, as well as two postdoctoral investigators and one student working toward a Ph.D. The researchers hope to discover specific toll-like receptor (TLR) antagonists to regulate corneal inflammation, which could lead to the development of novel anti-inflammatory medications that could serve as alternatives to steroids to treat the infections.

Bacterial keratitis is a serious cause of visual impairment not only in the United States but also worldwide, and contact lens wear is a major risk factor for the infection in the cornea, the clear covering over the front part of the eye.

"Organisms can infiltrate an intact cornea of a lens-wearer, and a biofilm can form on the contact lens," Dr. Pearlman says. Although correctly performed cleaning of contact lenses can remove the biofilm, or aggregation of micro-organisms, he adds, "When one considers that 34 million people in the United States and about 140 million people worldwide wear contact lenses, even a low percentage of side effects translates into a large number of affected individuals."

The TLR family of pathogen recognition molecules plays a critical role in recognizing and responding to pathogens in the body, initiating anti-microbial inflammatory responses to them that often result in damage to tissue. In the absence of live bacteria, TLRs also respond to microbial products and can induce an inflammatory response in the cornea.

With the latest grant, the researchers will study the activation of TLR4, which is the major stimulatory component of Gram-negative bacteria, by large molecules called lipopolysaccharides, which elicit strong immune responses. They also will examine responses inside epithelial cells in the human cornea and in a murine model of corneal inflammation. The investigators' goal will be to identify potential areas on the cell surface and inside the cells that would be good targets for anti-inflammatory intervention.

Dr. Pearlman is the principal investigator leading a multidisciplinary team investigating fungal and bacterial keratitis that also includes Mahmoud A. Ghannoum, Ph.D., E.M.B.A., professor and director of the Center for Medical Mycology in the Department of Dermatology; Loretta B. Szczotka-Flynn, O.D., M.S., associate professor of ophthalmology and visual sciences; and Arne Rietsch, Ph.D., assistant professor of molecular biology and microbiology.

The Department of Ophthalmology and Visual Sciences is part of the Visual Sciences Research Center, which encompasses more than 40 vision researchers in 18 departments at Case Western Reserve University and University Hospitals Case Medical Center campus, including pharmacology, pathology, molecular biology, epidemiology and biostatistics, chemistry and biomedical engineering.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Director of UT Southwestern center honored with first international neurology medal
2. Dynatronics to Supply Western Rehabilitation Health Networks 114 Clinics
3. Northwestern Memorial HealthCare and Lake Forest Hospital Sign Affiliation Agreement
4. Motorolas 802.11n Wireless LAN Solution Improves Patient Care and Wireless Security at Memorial Medical Center of Western Michigan
5. Community Health Centers and Western Governors University Partner to Address RN Shortage
6. Edward Announces New Neurosciences Institute in Partnership With Northwestern Medical Faculty Foundation
7. Join WQED Pittsburgh and The Press Club of Western Pennsylvania in Celebrating National Healthy Aging(R) Month and Kick Off Active Aging Week September 21-27
8. Catalyst Pharmaceutical Partners Licenses Exclusive Rights to New Class of GABA Aminotransferase Inhibitors From Northwestern University
9. UT Southwestern Responds to VA Announcement
10. Rabies Vaccination Program Underway in Western Pennsylvania
11. AHRF and Northwestern University to Present a Lecture on Hearing and Hearing Loss on August 26
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... ... 2017 , ... The Incentive Research Foundation is pleased to ... a groundbreaking analysis of how behavioral economics can be applied to the incentive, ... programs, the report highlights proven behavioral economics approaches and the powerful role emotions ...
(Date:4/27/2017)... ... April 27, 2017 , ... Last night, ... CAREGiverSM of the Year for her extraordinary compassion and lifelong dedication to serve ... American professional caregivers for the prestigious award each year – identifying a CAREGiver ...
(Date:4/27/2017)... Atlanta, GA (PRWEB) , ... April 27, 2017 , ... ... is a tragic spike in water-related accidents and drownings during the summer. While most ... reality is that these situations occur every day. Very few people are taking the ...
(Date:4/26/2017)... ... April 26, 2017 , ... Journal of Oral Implantology ... severe consequences to overall dental health, including complications with speech, eating, and overcompensation of ... implants to replace lost teeth. As the number of tooth replacements increase, it is ...
(Date:4/26/2017)... ... April 26, 2017 , ... Elisabete Miranda, president and ... by Enterprising Women magazine as one of its 2017 Enterprising Women of the ... Winners have demonstrated that they have fast-growth businesses, mentor or actively support other ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... MINNEAPOLIS , April 20, 2017  Cogentix ... company focused on providing the Urology, Uro/Gyn and ... reported that Ash Keswani has joined the Company ... In this newly created position, Mr. Keswani will ... and CEO. "Our organization is delighted ...
(Date:4/20/2017)... 2017 Research and Markets has ... and Market Prospects: Addressing Production Complexities Through Risk Management ... ... Biosimilar Pipeline and Market Prospects: Overcoming Production Complexities Through ... assessment of the current trends in the global biosimilars ...
(Date:4/20/2017)... 2017  CVS Pharmacy, the retail division of ... store design to enhance the retail customer experience ... products and expanded beauty selections paired with informational ... new offerings. Together with its innovative digital programs, ... customer experience at CVS Pharmacy.  ...
Breaking Medicine Technology: