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Cascade of Studies, New Clinical Tests Build the Case for Genetic Testing in Pharmacy Care Says Medco Expert

FRANKLIN LAKES, N.J., Feb. 26 /PRNewswire-FirstCall/ -- With more powerful, expensive and potentially dangerous medicines reaching the market on a daily basis, the time has come to leverage genetic tests that provide physicians with the confidence that they have prescribed the precise drug and dose tailored to their patient's unique genetic code, a leading authority on personalized medicine at Medco Health Solutions, Inc. (NYSE: MHS) today told industry leaders.

"We are at the precipice of a revolution in personalized medicine," said Felix Frueh, Medco vice president of personalized medicine research and development. "With greater frequency genetic testing is recommended in the medication label. Making such tests the standard of care can significantly reduce waste, improve patient care and raise the safety profile for powerful new medications."

Genetic tests associated with prescription medications represent an additional up-front cost in the early treatment of a condition. However, a building body of evidence is showing that genetic screenings can lead to greater savings over time from fewer hospital admissions and less waste, Frueh said. He predicts that the use of pharmacogenomic testing will become increasingly popular over the next several years as clinicians, patients and payors seek more opportunities to improve safety and efficacy in pharmacy care.

Pharmacogenomics is the science of capturing a patient's genetic information to help predict how a person is likely to respond to a wide variety of drugs, including commonly used medications such as pain relievers, blood thinners and cancer drugs. This information has a bearing on what drug is selected and may help optimize doses for particular drugs.

Addressing attendees of an audio conference hosted by magazine publisher Atlantic Information Services, Inc., Frueh - who prior to leading Medco's pharmacogenomic research efforts led a core genomics review team at the U.S. Food and Drug Administration (FDA) and chaired the first FDA-wide, interdisciplinary pharmacogenomics review group - said health care payors were an "overlooked constituency" in the emerging field of personalized medicine, but the improved outcomes and potential savings make it extremely pertinent to their interests.

Frueh cited several examples where gene tests can reduce the costs of care, including cancer therapies, which can cost tens of thousands of dollars a month. For instance, a $500 test for the HER-2 gene could determine whether spending $50,000 a year for a specific breast cancer drug makes sense, since the drug does not work on two-thirds of patients who are Her-2 negative.

Cost savings aside, the clinical need for testing is paramount. For example, a genetic screening can help prevent the occurrence of potentially fatal hypersensitivity reactions, which can result from the use of a certain HIV medication (abacavir) and seizure medication (carbamazepine) in patients with a genetic pre-disposition.

Frueh identified 11 drugs that likely will be paired with genetic tests if and when they reach the market between now and mid-2010. These compounds include treatments for cancer, heart failure, HIV, COPD/asthma, Huntington's disease, Alzheimer's disease, and high cholesterol.

Medco and Personalized Medicine

Medco has existing research collaborations with Mayo Clinic studying genetic consideration in the use of warfarin, and with LabCorp for breast cancer patients using tamoxifen. Medco anticipates having the results of these studies available within the next year. The company also has a research partnership with the Food and Drug Administration aimed at improving patient health and the quality of the delivery of care via pharmacogenomics, and it anticipates additional development partnerships with other health care entities.

In addition, the Medco Personalized Medicine Program offers solutions for payors to help enable them to leverage the potential advantages of personalized medicine by analyzing claims histories to identify patients who could benefit from genetic testing, communicating with physicians about testing options and results and engaging patients to educate them about genetic tests.

About Medco

Medco Health Solutions, Inc. (NYSE: MHS) is a leading health care company, serving the needs of more than 60 million people. Medco, the world's most advanced pharmacy(R), provides clinically driven pharmacy services designed to improve the quality of care and lower total health care costs for private and public employers, health plans, labor unions and government agencies of all sizes, and for individuals served by Medicare Part D Prescription Drug Plans. Through its unique Medco Therapeutic Resource Centers(R) and the Accredo Health Group, Medco's Specialty Pharmacy, the company is creating innovative models for the care of patients with chronic and complex conditions. Medco is a leader in the emerging field of personalized medicine and in applying evidence-based protocols to elevate the practice of pharmacy - a key element in reforming America's health care system. Medco is ranked number 51 on the Fortune 500 list, with 2008 revenues of more than $51 billion. For more information about Medco, go to

This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties that may cause results to differ materially from those set forth in the statements. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the risks and uncertainties that affect our business, particularly those mentioned in the Risk Factors section of the Company's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission.

SOURCE Medco Health Solutions, Inc.
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