Navigation Links
Carnegie Mellon engineering researchers automate analysis of protein patterns

PITTSBURGH Carnegie Mellon Universitys Justin Y. Newberg and Robert F. Murphy have developed a software toolbox that is intended to help bioscience researchers characterize protein patterns in human tissues.

Newberg, a Ph.D. student in biomedical engineering, described the automated protein pattern recognition tool and its underlying methods as important for identifying biomarkers that could be useful for cancer diagnosis and therapy.

Distribution of proteins in a cell or group of cells can be used to identify the state of surrounding tissue, whether it is healthy or diseased, said Newberg, the newsletter editor for Carnegie Mellons Graduate Biomedical Engineering Society. So, our tools can be used to develop novel approaches to screen tissue, which could have an immense benefit in such things as cancer diagnosis.

Newberg, a member of Murphys research group, added that researchers are increasingly collecting large numbers of images due to the availability of automated microscopes. These images provide an excellent opportunity for improving the understanding of biological processes, but also create a need for automated bioimage analysis tools. Development of such tools has been a major focus of Carnegie Mellons Center for Bioimage Informatics for many years.

Newberg said the Human Protein Atlas is an excellent example of a large scale dataset ripe for automated analysis. The atlas consists of more than 3,000 proteins imaged in 45 normal and 20 cancerous human tissues.

In a research article in the Journal of Proteome Research, Newberg and Murphy, the Ray and Stephanie Lane Professor of Computational Biology and a professor in the departments of Biological Sciences, Biomedical Engineering and Machine Learning at Carnegie Mellon, described how they applied their tools to analyze images of eight major subcellular location patterns with a high degree of accuracy. They pointed to their work as a strong indication that automated analysis of the whole atlas is feasible, and they plan to continue to study and characterize all of the proteins in the atlas.

Knowing the exact location of thousands of proteins in human cells will enable a much better understanding of how these cells work and could ultimately advance the detection and diagnosis of serious diseases, Murphy said.


Contact: Chriss Swaney
Carnegie Mellon University

Related medicine news :

1. Carnegie Mellon technique accelerates biological image analysis
2. Teams From Carnegie Mellon, Yale, Manitoba Win Tepper Schools 2008 McGinnis Venture Competition
3. Carnegie Mellons Tepper School of Business to Host 2008 Cornerstones Symposium on Building City of the Future, March 25
4. ANSYS Sponsors Dinosaurs Exhibit at Carnegie Museum of Natural History
5. Carnegie Mellon study shows just listening to cell phones significantly impairs drivers
6. NSF awards Carnegie Mellons Jacobo Bielak
7. Carnegie Mellon study identifies where thoughts of familiar objects occur inside the human brain
8. SuperArray Bioscience Corporation Licenses RNA Interference Patent From The Carnegie Institution
9. Carnegie Mellon algorithm identifies top 100 blogs for news
10. Carnegie Mellon neuroscientist proposes new theory of brain flexibility
11. Carnegie Mellon Establishes Ray and Stephanie Lane Center for Computational Biology
Post Your Comments:
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: