Navigation Links
Carnegie Mellon develops innovative method to detect genetic causes of complex diseases
Date:8/6/2009

PITTSBURGHComputational biologists at Carnegie Mellon University have developed an analytical technique to detect the multiple genetic variations that contribute to complex disease syndromes such as diabetes, asthma and cancer, which are characterized by multiple clinical and molecular traits.

Rather than searching one at a time for genetic alterations that cause a particular symptom or trait, as in most conventional approaches, the Carnegie Mellon scientists use a statistical method that enables them to uncover genome variations underlying an entire regulatory network of genes or traits that are responsible for complex diseases.

Professor Eric P. Xing and postdoctoral scientist Seyoung Kim report today in the online journal Public Library of Science (PLoS) Genetics that their graph-guided fused lasso (GFlasso) method showed increased power in detecting gene variants associated with complex symptoms compared with other methods. In one test, GFlasso successfully detected a gene variant already implicated in severe asthma and identified two additional variants that had not previously been associated with the condition. More study of the two variants will be necessary to confirm the association, Xing and Kim said.

"We know that some of the most common and most serious diseases that plague humans are caused not by a single genetic mutation, but by a combination of many genetic and environmental factors," said Xing, an associate professor of machine learning, language technologies and computer science. "Complicating the situation is that most complex diseases have a large number of clinical traits such as various symptoms, body metrics and family history, and that genome-wide gene expression profiling can identify tens of thousands of molecular traits associated with the disease."

Typically, many of these traits are correlated. For example, high blood pressure and high body weight might share some common genetic causes. If someon
'/>"/>

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle
2. Carnegie Mellon engineers create mobile video service
3. Carnegie Mellon scientists offer explanation for face blindness
4. Carnegie Mellon International Autism Symposium to Feature Groundbreaking Research, Oct. 17-18
5. Carnegie Mellon to host micromanufacturing conference
6. Trouble quitting?: A new Pitt-Carnegie Mellon smoking study may reveal why
7. Phoenix Health Systems Awarded Level 2 Carnegie Mellon University eSCM-SP Certification
8. Carnegie Corporation funds ASCB course on parasites for African scientists
9. Possible link between different forms of epilepsy found by Carnegie Mellon scientists
10. Carnegie Mellon researchers improve assessments of aortic aneurysms
11. Carnegie Mellon brain imaging study illustrates how remedial instruction helps poor readers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... signs of chronic inflammation in non-cancerous prostate tissue may ... cancer than those with no inflammation, according to results ... Johns Hopkins Kimmel Cancer Center. , The link between ... with so-called high-grade prostate cancer those with a ... presence of the most aggressive and rapidly growing prostate ...
(Date:4/17/2014)... study published today in PLOS Pathogens , children ... is common can mount an immune response to infection ... repeated bouts of high fever and illness and partially ... The findings may help researchers develop future interventions that ... parasite. , Each year, approximately 200 million cases of ...
(Date:4/17/2014)... the April issue of Immunity , Kevin J. ... Research, says it,s time to take a fresh look ... sepsis, which kills millions worldwide every year, including more ... into the bloodstream to fight an injury or infection ... maintaining good health without inflammation, wounds and infections ...
(Date:4/17/2014)... (April 17, 2014) Doctors who treat patients ... lymphangioleiomyomatosis (LAM) can face an agonizing treatment decision. ... the disease and help relieve shortness of breath. ... and sirolimus can cause potentially fatal complications following ... Dr. Daniel Dilling, medical director of Loyola University ...
(Date:4/17/2014)... By discovering a new mechanism that allows blood to ... UC Irvine and the Salk Institute have opened the ... stroke-induced brain damage. , A complex and devastating neurological ... primary reason for disability in the U.S. The blood-brain ... blood-borne material into the brain, causing the permanent deficits ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... experts say , SUNDAY, Dec. 27 (HealthDay News) -- ... infants on human milk, relatively few continue breast-feeding for ... an entire year. , Why not stick it ... moms, but California researchers say they found that returning ...
... cardiovascular disease, diabetes, study found , FRIDAY, Dec. 25 ... between having heavy sons and cardiovascular death, but having underweight ... Previous research has already linked obesity to higher rates of ... Studies have also shown that very thin people may be ...
... , , BOULDER, Colo., Dec. 25 ... : LULULEMON AD IN YOGA JOURNAL MAGAZINE: EFFECTIVE ADVERTISING , Lululemon, the ... of the park. It,s the kind of ad that earns its maker ... see the ad, featuring a disabled yogini, visit elephantjournal.com: , ...
... ... together nanotechnology to focus on Sports injury prevention and training , ... Mission Viejo, Calif. (PRWEB) December 25, ... first subsidiary for sports based technologies called MVP Sports Technologies, Inc., , ,MVP Sports ...
... depending on how product is designed, study shows , ... blamed for everything from promoting youth violence to contributing to ... parents who planned on passing by the video game aisle ... video games can sharpen certain thinking skills, increasing cognitive speed ...
... Today,s passage of health care reform in the U.S. Senate ... a promise we will make to every person living in this ... will be able to afford coverage and insurance companies will not ... other steps will include final passage after conference committee, effective implementation ...
Cached Medicine News:Health News:Many Women Quit Breast-Feeding Early 2Health News:Many Women Quit Breast-Feeding Early 3Health News:Waylon Lewis of elephantjournal.com: Lululemon Ad; Naropa University Budget 2Health News:Applied Technology Holdings, Inc. Forms First New Subsidiary Called MVP Sports Technologies, Inc. 2Health News:Video Games Could Boost Certain Thinking Skills 2Health News:Video Games Could Boost Certain Thinking Skills 3Health News:A Promise to Keep. Senate Vote is the First Step Toward the Promise of Quality, Affordable Health Care for All 2
(Date:1/14/2014)... 2014  Luminex Corporation (Nasdaq: LMNX ) today announced ... of 2013 on Monday, February 3, 2014. A press release ... of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) ... operating highlights and financial results for the fourth quarter and ...
(Date:1/14/2014)... 14, 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio ... acquired Progressive Home Medical Equipment, Inc. ("Progressive") of ... of the acquisition were not disclosed. Progressive ... a wide range of sleep, mobility, and respiratory products to ...
(Date:1/14/2014)... 2014   NuAire , a manufacturer of ergonomically designed laboratory ... Koki of Japan to sell and ... . NuAire will utilize its network of sales professionals throughout ... to offer assistance in application use, product benefits and ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
0.6mm Tip x10mm Shaft, Straight Shaft, 90 Degree Hook at Tip; overall length 120mm; in Titianium....
... SURPASS Perfusion Catheter is indicated ... stenotic portion of a coronary ... for the purpose of improving ... Catheters are also designed to ...
16mm from Mid-screw to Tips, blunt tips; overall length 110mm; Stainless Steel...
16mm from Mid-Screw to Blunt Tips, Gently Curved Blades; overall length 120mm; Stainless Steel...
Medicine Products: