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Caris Diagnostics Providing KRAS Mutational Analysis for Colon Cancer Patients
Date:6/24/2008

Providing Information on Response to Erbitux and Vectibix

IRVING, Texas and PHOENIX, June 24 /PRNewswire/ -- Caris Diagnostics (Caris Dx), a leading provider of the highest quality diagnostic, translational development and pharmaceutical services encompassing anatomic pathology and molecular testing, announced that it is now offering KRAS mutation analysis, designed to provide information on which colon cancer patients are most likely to respond to cetuximab (Erbitux) co-marketed by ImClone and Bristol-Myers Squibb or panitumumab (Vectibix) developed by Amgen.

This assay, which can be performed on biopsies taken for the initial cancer diagnosis, identifies those patients who have somatic mutations in KRAS, which is associated with a lack of response to Erbitux or Vectibix. This prognostic information has recently been validated in a number of retrospective studies and will help better suggest which patients are most likely not going to respond to Erbitux or Vectibix, two chemotherapies widely being utilized to treat colon cancer. Caris Dx's KRAS assay is comprehensive in that it detects any and all nucleotide changes at the three validated KRAS codons (12, 13, and 61) that alter amino acids at these positions, offering a distinct advantage over other laboratories that may only screen for a few specific mutations in codons 12 and 13.

"Responding to oncologists needs for more and better information at the bedside, we are proud to be at the forefront of providing the newest, valuable molecular tests with the consistent quality and reproducibility that physicians have come to expect from Caris Dx," said Dr. Robert Penny, CEO of Caris MPI, the molecular profiling arm of Caris Dx. "We are excited to provide this vital information to clinicians at the time of their initial diagnosis to improve the likelihood of success with the patient's first therapy."

A recent Journal of Clinical Oncology study found that none of the 24 patients wi
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