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Cardium Reports on New Excellarate(TM) Product Formulations to Expand Commercialization Potential Into Multiple Wound Healing Applications
Date:5/7/2009

limitations such as requiring a regimen of repeated wound cleanings and product re-administrations, or multiple trips to a treatment center, or custom produced and expensive skin substitute products. In addition, many patients, including approximately one in seven participants in the MATRIX clinical study, have wounds that do not close even after treatments with what are regarded as the most advanced wound care therapies currently available (i.e., repeat-administration therapies using Becaplermin protein [Regranex(R)] or negative pressure pumps, or "living-skin" equivalents).

With the new product formulation enhancements and the accumulating data on Excellarate, this technology has the potential to be developed into additional cost-effective therapeutics with expanded clinical utility. The broader fields of wound healing and tissue repair involve an order of magnitude more patients than those with diabetic ulcers, and these other fields are likewise in need of innovative products. There are a number of key market drivers behind the growth in advanced wound care products. Non-healing or slow healing wounds in patients are highly susceptible to becoming infected, both in hospital and out. Furthermore, the use of antibiotics in these patients has resulted in the outgrowth of antibiotic resistant pathogens. Most importantly for patients and their physicians, wounds that have become infected can lead to amputations, a result that is often associated with a dramatic increase in mortality even in societies with optimal medical care. In the United States, for example, non-healing ulcers among diabetic patients are the leading cause of amputation, and even with care approximately half of such patients die within three years of their amputation.

These emerging trends and growing market demand are evidenced by the recent success of negative pressure wound therapy products, such as those marketed and sold in the United States by Kine
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SOURCE Cardium Therapeutics
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