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Cardium Reports on New Excellarate(TM) Product Formulations to Expand Commercialization Potential Into Multiple Wound Healing Applications
Date:5/7/2009

intained in a physician's office using a standard refrigerator (at a temperature of about 4 degrees Celsius) and to have a shelf life of 12-18 months. It will also be formulated as an easy-to-use single syringe that is pre-mixed and ready to be applied to patients' wounds.

With these product formulation enhancements and the accumulating data on Excellarate, Cardium is now focused on establishing additional cost-effective therapeutics that carry the potential to extend well beyond the initial indication of non-healing diabetic foot ulcers. In addition to the single syringe refrigerated formulation to facilitate storage and ease-of-use, Cardium and its manufacturing partners are developing low-cost and efficient large-scale production processes for DNA-based therapeutics using bioreactors with high cell densities and high-titer productivities. The relatively low dosing requirements for this new class of product candidates is enabled by TRC's GAM technology which causes the protein to be produced by a patient's own cells for a sustained period of time and locally released where it is needed within the wound site. The low dosing requirements relative to protein-based therapeutics, combined with the much lower costs of DNA-based product manufacturing, creates the potential for a new class of highly effective low cost therapeutics for application in a number of different tissue repair and wound treatment settings.

The Excellarate product candidate is initially being developed to facilitate wound closure in non-healing diabetic foot ulcers, which affect about 15% of the 24 million diabetic patients in the United States or about 3.6 million patients. The ability to achieve closure of chronic, non-healing wounds following application of a simple topical gel is considered to be particularly important for patient populations with chronic diseases such as diabetes. Available advanced wound care products for these patients have a number of
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SOURCE Cardium Therapeutics
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