Navigation Links
Cardium Reports Positive Data From Matrix Phase 2b Study of Excellarate(TM) Topical Gel for Non-Healing Diabetic Foot Ulcers and Plans for Phase 3 Program
Date:10/14/2009

f the groups, the 31% wound closure rate observed in the SOC group was similar to that observed in prior published studies and substantially lower than that observed for patients receiving Excellarate or collagen alone. Among patients receiving a single dose of Excellarate, there was a 55% relative improvement in complete wound closure by 12 weeks as compared to the SOC group, which is considered to be a key efficacy criterion for a Phase 3 product registration program.

During the course of the Phase 2b Matrix study, some investigators expressed an interest in having the flexibility to re-dose patients (to allow for a second or third treatment during the 12-week study period) in response to observed healing slowdowns or plateaus following an initially rapid healing response among some patients. In addition, while early rapid healing following product administration was not a prespecified efficacy measure, the unblinded Phase 2b data revealed that patients receiving Excellarate exhibited a 108% relative improvement (decrease in ulcer radius) as compared to SOC over the first week following a one-time administration of product, and a 50% relative improvement was observed as an average over the first four weeks. The Phase 2b clinical study included a second dose treatment cohort, but the observed healing slowdowns or plateaus did not necessarily coincide with the protocol's established second dosing at week 4 following initial dosing, and a number of patients prespecified by randomization to receive a second dose either did not require it (because their wounds had already closed) or received only an extremely small second dose (because their wounds were almost closed). Based on continuing safety data from the Matrix Phase 2b study, as well as the open label Phase 1/2 clinical study and preclinical research, all of which included some re-dosing, the Excellarate product candidate appears to be both safe and well tolerated, with no significant differences o
'/>"/>

SOURCE Cardium Therapeutics
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related medicine news :

1. Cardium Announces Commercial Development of Excellagen(TM) a Customized Collagen-Based Topical Gel for Initial Use as an Adjunct to Surgical Debridement in Patients With Diabetic Foot Ulcers
2. Scientific Journal Gene Therapy Reports That Cardiums Gene Activated Matrix Technology Accelerates Periodontal Tissue Regeneration
3. Cardium Reports on Second Quarter 2009 Financial Results and Recent Developments
4. Cardium Completes Sale of InnerCool Therapies Business to Royal Philips Electronics
5. Cardium Receives Preliminary Notification of Inclusion in the Russell 3000(R) Index and Russell Global(R) Index
6. Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting
7. Cardium Reports on First Quarter 2009 Financial Results and Recent Developments
8. Cardium Reports on New Excellarate(TM) Product Formulations to Expand Commercialization Potential Into Multiple Wound Healing Applications
9. Cardium Provides Update Regarding Exchange Listing Compliance Plan Accepted by NYSE Amex
10. Cardiums InnerCool Announces Journal of Neurotrauma Highlights Hypothermia Therapys Role in Post Cardiac Arrest, and Traumatic Brain and Spinal Cord Injury Patients
11. Cardium Reports on Recent Highlights, Financial Results and 2009 Outlook
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (PRWEB) October 01, 2014 Farmington ... including a redefined mission and visual identity helping ... of partnering with them to create greater benefit ... brand that focuses on empowering customers to better ... , The crown jewel of the rebrand is ...
(Date:10/1/2014)... Between 23 million and 50 million people suffer ... from the National Institutes of Health (NIH) and the ... them have something else in common: They have a ... Gluten Free Therapeutics, makers of CeliVites nutritional supplements, ... publishing a series of blog posts aimed at educating ...
(Date:10/1/2014)... Anti Aging Clinic (AntiAgingClinic.ca), the Greater Toronto ... choice, is announcing a discounted cost on Botox units, ... “We’re doing this because we want to give as ... clinic in Toronto,” says Dr. Brian Sieber, founder of ... Aging Clinic, including laser facials, genesis laser facials, ...
(Date:10/1/2014)... Watsonville, California (PRWEB) October 01, 2014 ... initiative to benefit a very special cause. The ... and support for Paws for Veterans, a nonprofit ... veterans, while also rescuing shelter dogs that would ... purchases of featured products will support monthly donations ...
(Date:10/1/2014)... OXNARD, CA (PRWEB) October 01, 2014 ... of the Anacapa Dental Art Institute in Oxnard and ... of Bangalore providing full mouth rehabilitation training. , “Speaking ... need of these transformative procedures to get the help ... mouth rehabilitation may involve repairing previous dental work, providing ...
Breaking Medicine News(10 mins):Health News:Farmington Company Launches Rebrand and New Positioning 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... dengue virus Monday with 56 fresh cases being admitted to ... Delhi government called an// urgent meeting to review the situation. ... Institute of Medical Sciences (AIIMS) reported 41, taking the total ... 941 infected with the mosquito-borne virus, around 579 are residents ...
... Whenever one has to watch shaky images recorded by an ... ever consider how the brain //restores an almost continuous shaky ... back and forth taking also into consideration our bodies which ... ,Researchers at the Salk Institute for Biological Studies ...
... come up with novel methods to study 'better than nature' ... in maintaining a healthy cardiovascular system without the typical side ... presented at the Annual Meeting of the American College of ... high allicin garlic macerate can be delivered to the body ...
... extended to 2015. , The commission had been assigned the task ... needs of the mentally ill and was set to finish next ... response to the Mason Inquiry into Mental Health Services. They were ... has been trying to meet. , ,According to Health ...
... tide waits for no man and none other than ‘gen–present’ ... the ebb and flow of waters continue unabated, people are ... tomorrows. Living on the edge, seeking newer excitement propelled by ... obsession. Today, ‘failure’ is unacceptable - a mute ...
... of over 5,000 lbs. of ground beef as a precautionary ... that was processed and/or handled by the firm. ... that we have a negative test on the beef in ... proceed." ,It has been estimated that the 5,200 lbs. ...
Cached Medicine News:Health News:56 New Dengue Cases; Delhi Govt. to Review Situation 2Health News:Perception Stabilized – Thanks to Your Brains 2Health News:Perception Stabilized – Thanks to Your Brains 3Health News:New Garlic Product Mimics Garlic to Perfection 2Health News:Mental Health: Mind at Peace or in Pieces? 2Health News:Mental Health: Mind at Peace or in Pieces? 3Health News:Mental Health: Mind at Peace or in Pieces? 4Health News:Precautionary Recall of Beef over E.coli Contamination Concerns 2
(Date:10/1/2014)...  Varian Medical Systems (NYSE: VAR ) ... fourth quarter of fiscal year 2014 following the close ... news release will be followed by a teleconference available ... news release and a link to the conference call ... www.varian.com/investor .  To access the teleconference call and ...
(Date:10/1/2014)... , Oct. 1, 2014  Express Scripts (NASDAQ: ... nationally available 2015 Express Scripts Medicare ® Prescription ... network featuring Walgreens (NYSE: WAG ) (NASDAQ: ... value, choice and clinical support  for their Medicare dollars. ... Scripts Medicare Value or Choice ...
(Date:10/1/2014)... Mass. , Oct. 1, 2014   ... AEX: PHIA) today announced its eCareCoordinator and eCareCompanion ... U.S. Food and Drug Administration (FDA). A part ... telehealth programs , eCareCoordinator and eCareCompanion are focused ... the first clinical applications to be available through ...
Breaking Medicine Technology:Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 2Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 3Express Scripts Collaborates with Walgreens to Create Value-Driven Medicare Prescription Drug Plan Pharmacy Network 4Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: