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Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting
Date:5/28/2009

h localized sustained production, Excellarate comprises an adenovector with a gene encoding human platelet-derived growth factor-B (Ad5PDGF-B), incorporated into a 3-dimensional biocompatible matrix of collagen, which can be applied as a topical gel directly to an ulcer site. The Excellarate biocompatible matrix is believed to have at least two key beneficial functions. First, the matrix can essentially hold the Ad5PDGF-B vector in place at the wound site until infiltrating wound-healing cells arrive. Second, the matrix can act as scaffolding to promote the migration and in-growth of cells that are responsible for accumulation of granulation tissue, a key part of the wound healing process. Studies using the Excellarate product candidate have shown that tissue repair cells such as macrophages, fibroblasts, endothelial cells and endothelial progenitor cells, which originate in viable tissue surrounding a wound site, naturally migrate into and proliferate within the gene-containing matrix.

Once in the matrix, cells that have taken up the PDGF-B gene act as local bioreactors that produce PDGF-B protein. PDGF-B is a known cyto-attractant and thus induces repair cells to migrate from the normal wound margins into the wound bed. PDGF-B is also known for its ability to stimulate repair cell proliferation so those cells that have migrated into the wound bed and are exposed to the protein can increase in number leading to a greater amount of granulation tissue. Studies have shown that the PDGF-B gene is expressed in tissue repair cells as early as one day following drug application and for as long as seven days. In the case of Excellarate, the PDGF-B protein that is expressed contains a collagen-binding domain, which further helps the protein to be retained in the wound bed environment where it is needed most. Although the protein is synthesized by wound repair cells only for as long as the gene is expressed, the duration of its availabilit
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SOURCE Cardium Therapeutics
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